A Novel Osteogenic Oxysterol Compound for Therapeutic Development to Promote Bone Growth: Activation of Hedgehog Signaling and Osteogenesis Through Smoothened Binding

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

Questions About Spine Fusion Product Prompt a New Process for Reviewing Data

(2011) M. Mitka   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Full-Length spp24, but Not Its 18.5-kDa Proteolytic Fragment, Inhibits Bone-Healing in a Rodent Model of Spine Fusion

(2011) Chananit Sintuu et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo

(2011) Jared S. Johnson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

(2011) Eugene J. Carragee et al.   Spine Journal

High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo

(2011) Janette N. Zara et al.   TISSUE ENGINEERING PART A

Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress

(2010) Woo-Kyun Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Analysis of prevertebral soft-tissue swelling and dysphagia in multilevel anterior cervical discectomy and fusion with recombinant human bone morphogenetic protein–2 in patients at risk for pseudarthrosis

(2010) Joseph B. Stachniak et al.   JOURNAL OF NEUROSURGERY-SPINE

Formation of Painful Seroma and Edema After the Use of Recombinant Human Bone Morphogenetic Protein-2 in Posterolateral Lumbar Spine Fusions

(2010) Mark P. Garrett et al.   NEUROSURGERY

Graft Options in Posterolateral and Posterior Interbody Lumbar Fusion

(2010) Jeffrey A. Rihn et al.   SPINE

Cytokine-Mediated Inflammatory Reaction Following Posterior Cervical Decompression and Fusion Associated With Recombinant Human Bone Morphogenetic Protein-2

(2010) Brett N. Robin et al.   SPINE

OSTENE, A NEW ALKYLENE OXIDE COPOLYMER BONE HEMOSTATIC MATERIAL, DOES NOT INHIBIT BONE HEALING

(2010) Clara E. Magyar et al.   Operative Neurosurgery

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Multipotent Differentiation Potentials of Murine Primary Bone Marrow Stromal Cells and Mesenchymal Stem Cell Line C3H10T1/2

(2008) Li Zhao et al.   CALCIFIED TISSUE INTERNATIONAL

Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling

(2008) Christopher M. Amantea et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Effects of Lentiviral Gene Therapy With Bone Morphogenetic Protein-2-Producing Bone Marrow Cells on Spinal Fusion in Rats

(2008) Masashi Miyazaki et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

The Adjunctive Effect of a Binding Peptide on Bone Morphogenetic Protein Enhanced Bone Healing in a Rodent Model of Spinal Fusion

(2008) Ahmet Alanay et al.   SPINE

A porcine collagen-derived matrix as a carrier for recombinant human bone morphogenetic protein-2 enhances spinal fusion in rats

(2008) Masashi Miyazaki et al.   Spine Journal

Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2)

(2007) David A. Wong et al.   Spine Journal