Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ

Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effect of food restriction

(2021) María Rodríguez et al.   NUTRITIONAL NEUROSCIENCE

An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models

(2020) Min Jeong Choi et al.   DIABETOLOGIA

PPARγ and PPARα synergize to induce robust browning of white fat in vivo

(2020) Tobias Kroon et al.   Molecular Metabolism

The autocrine role of FGF21 in cultured adipocytes

(2020) Sarah Justesen et al.   BIOCHEMICAL JOURNAL

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals

(2020) Anja Böhm et al.   Scientific Reports

The nutrient sensing pathways FoxO1/3 and mTOR in the heart are coordinately regulated by central leptin through PPARβ/δ. Implications in cardiac remodeling

(2020) Blanca Rubio et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fibroblast Growth Factor 21 and Browning of White Adipose Tissue

(2019) Daniel Cuevas-Ramos et al.   Frontiers in Physiology

Critical Role of Nrf2 in Experimental Ischemic Stroke

(2019) Lei Liu et al.   Frontiers in Pharmacology

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

(2019) Olof S. Dallner et al.   NATURE MEDICINE

Subtyping obesity

(2019) Alan Morris   Nature Reviews Endocrinology

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases

(2019) Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster

(2019) Jo E. Lewis et al.   Molecular Metabolism

Suppression of Nrf2 attenuates adipogenesis and decreases FGF21 expression through PPAR gamma in 3T3-L1 cells

(2018) Bo-Rahm Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

(2018) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice

(2018) Tamiris Lima Rachid et al.   PLoS One

Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles

(2018) Yiming Cheng et al.   Cell Reports

Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats

(2018) Diane M. Sepa-Kishi et al.   Adipocyte

Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression

(2017) Cristina Mora et al.   JOURNAL OF ENDOCRINOLOGY

ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21

(2017) Seul Gi Kang et al.   JOURNAL OF ENDOCRINOLOGY

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Leptin as a Potential Regulator of FGF21

(2016) Mohamed Asrih et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity

(2016) Ricardo J. Samms et al.   ENDOCRINOLOGY

CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5

(2016) Szu-Yi Chou et al.   Scientific Reports

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction

(2015) Marta Toral et al.   CLINICAL SCIENCE

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

(2012) Heidi E. Kocalis et al.   PLoS One

FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

(2012) Murielle M. Véniant et al.   PLoS One

Regulation of Insulin-Stimulated Glucose Uptake in Rat White Adipose Tissue upon Chronic Central Leptin Infusion: Effects on Adiposity

(2011) Elena Bonzón-Kulichenko et al.   ENDOCRINOLOGY

Acute Disruption of Leptin Signalingin VivoLeads to Increased Insulin Levels and Insulin Resistance

(2011) Jasna Levi et al.   ENDOCRINOLOGY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Administration of PPARβ/δ agonist reduces copper-induced liver damage in mice: possible implications in clinical practice

(2011) Alvaro A. Sanchez-Siles et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is highly expressed in liposarcoma and promotes migration and proliferation

(2011) Kay-Dietrich Wagner et al.   JOURNAL OF PATHOLOGY

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue

(2009) Mayoura Keophiphath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

(2009) Constantinos Christodoulides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels

(2009) A. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

(2009) Shigeki Sugii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist

(2007) Barry G. Shearer et al.   MOLECULAR ENDOCRINOLOGY