Article
Medicine, Research & Experimental
Ali Taylan, Baris Akinci, Burak Toprak, Merih Birlik, Fatma Demet Arslan, Hasan Ekerbicer, Baris Gundogdu, Ayfer Colak, Bahar Engin
Summary: This study investigated the relationship between disease activity and adipocytokine levels in early rheumatoid arthritis patients, finding that those with high disease activity had higher BMI and leptin levels, which decreased after treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria E. Casado, Sandra Canelles, Eduardo Arilla-Ferreiro, Laura M. M. Frago, Vicente Barrios
Summary: Leptin can regulate lipid metabolism and reduce adipose tissue stores by inhibiting food intake and altering adipocyte sensitivity to insulin. This study investigated the effects of chronic central leptin administration on lipid metabolism and inflammatory- and insulin-signaling pathways in epididymal adipose tissue. Changes were observed in the expression of key enzymes involved in lipid metabolism, as well as insulin-signaling targets and inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jihoon Shin, Shinichiro Toyoda, Yosuke Okuno, Reiko Hayashi, Shigeki Nishitani, Toshiharu Onodera, Haruyo Sakamoto, Shinya Ito, Sachiko Kobayashi, Hirofumi Nagao, Shunbun Kita, Michio Otsuki, Atsunori Fukuhara, Kazuhiro Nagata, Iichiro Shimomura
Summary: HSP47 is identified as a key determinant of body adiposity, with abundant expression in adipose tissue. It is influenced by factors such as diet, exercise, hormones, and genetics. HSP47 affects body fat levels through its role in collagen dynamics, FAK signaling, and protection of PPAR gamma protein.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Absalon D. Gutierrez, Carlos A. Flores, Sapna Naik, MinJae Lee, Parisa Asgarisabet, Masha Resman, Miryoung Lee, Joseph B. McCormick, Susan P. Fisher-Hoch
Summary: Resistin decreased as glucose tolerance deteriorated, positively associated with IL-1 beta and IL-8, inversely associated with TNF-alpha, and not significantly associated with IL-6. There are complex relationships between resistin, adipokines, and demographic variables.
Article
Endocrinology & Metabolism
Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Summary: This study found that serum EDA levels were significantly higher in newly diagnosed type 2 diabetes mellitus patients, and positively correlated with various metabolic indexes such as body mass index and fasting plasma glucose. Additionally, EDA levels were independently associated with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Runjie Song, Yaqi Du, Peng Li, Lijun Zhou, Han Zheng, Xiaohui Lu, Shenghong Wang, Wenqiang Ma, Hua Zhang, Xiangdong Li
Summary: This study found that LETMD1 plays a crucial role in the thermogenesis and energy homeostasis of brown adipose tissue. By regulating mitochondrial structures and functions, LETMD1 can affect mitochondrial fission and the concentration of Ca2+, thereby influencing the thermogenesis of brown adipose tissue.
Article
Psychiatry
Shalaila S. Haas, Alison Myoraku, Kathleen Watson, Thalia Robakis, Sophia Frangou, Fahim Abbasi, Natalie Rasgon
Summary: This study investigates the influence of metabolic drivers on hippocampal functional connectivity in healthy adults and finds a link between metabolic abnormality and hippocampal function. The results indicate that individuals with increased metabolic deviance exhibit lower functional connectivity and integration of the hippocampus with the resting-state networks.
EUROPEAN PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Martina Chiriaco, Lorenzo Nesti, Allan Flyvbjerg, Alain Golay, Julie-Anne Nazare, Christian-Heinz Anderwald, Asimina Mitrakou, Roberto Bizzotto, Andrea Mari, Andrea Natali
Summary: The impact of obesity on glucose homeostasis varies greatly among individuals, which may be attributed to different concentrations of adipokines. Subjects with inappropriately elevated leptin levels for their fat mass show whole-body/adipose tissue insulin resistance and hyperinsulinemia, regardless of BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Fotini Filippopoulou, George I. Habeos, Vagelis Rinotas, Antonia Sophocleous, Gerasimos P. Sykiotis, Eleni Douni, Dionysios V. Chartoumpekis
Summary: Glucocorticoids are widely used in the long-term treatment of autoimmune and inflammatory diseases. However, they can have adverse effects such as hyperglycemia and osteoporosis, which are partially mediated by oxidative stress. This study found that glucocorticoid-induced hyperinsulinemia and osteoporosis are independent of NRF2.
Article
Endocrinology & Metabolism
Eirini Bouzoni, Nikolaos Perakakis, Margery A. Connelly, Angeliki M. Angelidi, Eleni Pilitsi, Olivia Farr, Konstantinos Stefanakis, Christos S. Mantzoros
Summary: The levels of PCSK9, ANGPTL3, and FABP4 are associated with markers of lipid metabolism and are higher in HIV-lipoatrophy. The levels of PCSK9 and ANGPTL3 decrease during food deprivation, while FABP4 remains unaffected. Leptin treatment does not affect the levels of PCSK9, ANGPTL3, and FABP4.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Multidisciplinary Sciences
Johnny E. Elguero, Guangmei Liu, Katherine Tiemeyer, Shruthi Bandyadka, Heena Gandevia, Lauren Duro, Zhenhao Yan, Kimberly Mccall
Summary: This study found that Drosophila mutants lacking the phagocytic receptor Draper have phagocytic defects leading to neurodegenerative diseases. The study also discovered that phagocytic defects cause neurodegeneration through increased immune signaling.
Article
Biochemistry & Molecular Biology
Sanjali Charles, Yutong Liu, Wandia Kimita, Juyeon Ko, Sakina H. Bharmal, Maxim S. Petrov
Summary: This study aimed to investigate the effects of acute nutritional ketosis on plasma levels of asprosin and leptin, as well as the potential impact of abdominal fat phenotypes. The results showed that acute nutritional ketosis did not significantly affect the plasma levels of asprosin and leptin, and the abdominal fat phenotypes did not have a significant impact on the circulating levels of these hormones.
Article
Dermatology
Dan Wang, Zhibing Fu, Lihua Gao, Jinrong Zeng, Yaping Xiang, Lu Zhou, Xiaoliang Tong, Xiao-Qi Wang, Jianyun Lu
Summary: This study identifies the increased expression of IRF9 and STAT2 in melanoma cells under BRAFis treatment and verifies their roles in resistance. Overexpression of IRF9 or STAT2 leads to decreased sensitivity to BRAFis treatment, while knockdown increases sensitivity. Further experiments show that IRF9-STAT2 signaling controls GSDME-dependent pyroptosis through restoring GSDME transcription. Targeting IRF9/STAT2 may provide a more effective treatment to prevent melanoma resistance to BRAFis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Clinical Neurology
Gulay Tasci, Suheda Kaya, Mehmet Kalayci, Murad Atmaca
Summary: This study compared the levels of acyl ghrelin (AG), des-acyl ghrelin (DAG), and leptin in patients with antisocial personality disorder (ASPD) and healthy controls. The results showed that AG and DAG levels were significantly higher in patients, while leptin levels were significantly lower. There was also a positive correlation between AG and DAG levels and impulsivity and aggression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Arjun Trivedi, Sandra Babic, Mark Heiman, William T. Gibson, Jean-Pierre Chanoine
HORMONE AND METABOLIC RESEARCH
(2017)
Review
Genetics & Heredity
Emma Hitchcock, William T. Gibson
JOURNAL OF GENETIC COUNSELING
(2017)
Article
Endocrinology & Metabolism
Frank K. Huynh, Xiaoke Hu, Zhihong Lin, James D. Johnson, Matthew D. Hirschey
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Review
Endocrinology & Metabolism
Y. Kaur, R. J. de Souza, W. T. Gibson, D. Meyre
Article
Genetics & Heredity
Heba Yasin, William T. Gibson, Sylvie Langlois, Robert M. Stowe, Erica S. Tsang, Leora Lee, Jenny Poon, Grant Tran, Christine Tyson, Chi Kin Wong, Marco A. Marra, Jan M. Friedman, Farah R. Zahir
JOURNAL OF HUMAN GENETICS
(2019)
Article
Biochemical Research Methods
Hadi R. Ali, Mohammed A. Assiri, Peter S. Harris, Cole R. Michel, Youngho Yun, John O. Marentette, Frank K. Huynh, David J. Orlicky, Colin T. Shearn, Laura M. Saba, Richard Reisdorph, Nichole Reisdorph, Matthew D. Hirschey, Kristofer S. Fritz
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Geriatrics & Gerontology
Justin W. Nicholatos, Timothy M. Robinette, Saurabh V. P. Tata, Jennifer D. Yordy, Adam B. Francisco, Michael Platov, Tiffany K. Yeh, Olga R. Ilkayeva, Frank K. Huynh, Maxim Dokukin, Dmytro Volkov, Michael A. Weinstein, Adam R. Boyko, Richard A. Miller, Igor Sokolov, Matthew D. Hirschey, Sergiy Libert
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Clinical Neurology
Anita N. Datta, Aspasia Michoulas, Ilaria Guella, Michelle Demos, Shelin Adam, Cyrus Boelman, Corneliu Bolbocean, Sarah E. Buerki, Tara Candido, Patrice Eydoux, Daniel M. Evans, William Gibson, Gabriella Horvath, Linda Huh, Tanya N. Nelson, Graham Sinclair, Tamsin Tarling, Eric B. Toyota, Katelin N. Townsend, Margot Van Allen, Clara van Karnebeek, Suzanne Vercauteren
JOURNAL OF CHILD NEUROLOGY
(2019)
Article
Multidisciplinary Sciences
Eva Tuduri, Maria M. Glavas, Ali Asadi, Robert K. Baker, Cara E. Ellis, Galina Soukhatcheva, Marjolaine Philit, Frank K. Huynh, James D. Johnson, C. Bruce Verchere, Timothy J. Kieffer
SCIENTIFIC REPORTS
(2019)
Article
Genetics & Heredity
Sharri S. Cyrus, Ana S. A. Cohen, Ruky Agbahovbe, Kristiina Avela, Kit S. Yeung, Brian H. Y. Chung, Ho-Ming Luk, Nataliya Tkachenko, Sanaa Choufani, Rosanna Weksberg, Elena Lopez-Rangel, Kathleen Brown, Margarita S. Saenz, Shayna Svihovec, Shawn E. McCandless, Lynne M. Bird, Aixa G. Garcia, Michael J. Gambello, Kirsty McWalter, Rhonda E. Schnur, Jianghong An, Steven J. M. Jones, Sanjiv K. Bhalla, Hailey Pinz, Stephen R. Braddock, William T. Gibson
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2019)
Review
Genetics & Heredity
Sharri Cyrus, Deepika Burkardt, David D. Weaver, William T. Gibson
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2019)
Article
Clinical Neurology
Christopher C. Y. Mak, Dan Doherty, Angela E. Lin, Nancy Vegas, Megan T. Cho, Geraldine Viot, Clemantine Dimartino, James D. Weisfeld-Adams, Davor Lessel, Shelagh Joss, Chumei Li, Claudia Gonzaga-Jauregui, Yuri A. Zarate, Nadja Ehmke, Denise Horn, Caitlin Troyer, Sarina G. Kant, Youngha Lee, Gisele E. Ishak, Gordon Leung, Amanda Barone Pritchard, Sandra Yang, Eric G. Bend, Francesca Filippini, Chelsea Roadhouse, Nicolas Lebrun, Michele G. Mehaffey, Pierre-Marie Martin, Benjamin Apple, Francisca Millan, Oliver Puk, Mariette J. V. Hoffer, Lindsay B. Henderson, Ruth McGowan, Ingrid M. Wentzensen, Steven Pei, Farah R. Zahir, Mullin Yu, William T. Gibson, Ann Seman, Marcie Steeves, Jill R. Murrell, Sabine Luettgen, Elizabeth Francisco, Tim M. Strom, Louise Amlie-Wolf, Angela M. Kaindl, William G. Wilson, Sara Halbach, Lina Basel-Salmon, Noa Lev-El, Jonas Denecke, Lisenka E. L. M. Vissers, Kelly Radtke, Jamel Chelly, Elaine Zackai, Jan M. Friedman, Michael J. Bamshad, Deborah A. Nickerson, Russell R. Reid, Koenraad Devriendt, Jong-Hee Chae, Elliot Stolerman, Carey McDougall, Zoe Powis, Thierry Bienvenu, Tiong Y. Tan, Naama Orenstein, William B. Dobyns, Joseph T. Shieh, Murim Choi, Darrel Waggoner, Karen W. Gripp, Michael J. Parker, Joan Stoler, Stanislas Lyonnet, Valerie Cormier-Daire, David Viskochil, Trevor L. Hoffman, Jeanne Amiel, Brian H. Y. Chung, Christopher T. Gordon
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Cell Biology
Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. Hirschey, Haim Y. Cohen
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Endocrinology & Metabolism
Frank K. Huynh, Brett S. Peterson, Kristin A. Anderson, Zhihong Lin, Aeowynn J. Coakley, Fiara M. S. Llaguno, Thi-Tina N. Nguyen, Jonathan E. Campbell, Samuel B. Stephens, Christopher B. Newgard, Matthew D. Hirschey
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Genetics & Heredity
Laura S. Farach, William T. Gibson, Steven P. Sparagana, Mark Nellist, Connie T. R. M. Stumpel, Marja Hietala, Elliott Friedman, Deborah A. Pearson, Susan P. Creighton, Annemiek Wagemans, Reveel Segel, Efrat Ben-Shalom, Kit Sing Au, Hope Northrup
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2017)