Anticancer Potential of Betulonic Acid Derivatives

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

(2021) Codruţa Şoica et al.   Frontiers in Endocrinology

MARINE NATURAL PRODUCTS WITH HIGH ANTICANCER ACTIVITIES

(2020) Dario Matulja et al.   CURRENT MEDICINAL CHEMISTRY

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

(2020) Amit S. Choudhari et al.   Frontiers in Pharmacology

Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial

(2020) Tatul Saghatelyan et al.   PHYTOMEDICINE

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

(2020) Roxana Ghiulai et al.   MOLECULES

Betulonic acid—cyclodextrins inclusion complexes

(2019) Laura Sbârcea et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Betulin and its derivatives as novel compounds with different pharmacological effects

(2019) Shayan Amiri et al.   BIOTECHNOLOGY ADVANCES

Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery

(2019) Fernanda Majolo et al.   Phytochemistry Letters

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

(2019) Anna Hordyjewska et al.   PHYTOCHEMISTRY REVIEWS

Synthesis, Anticancer and Antibacterial Activity of Betulinic and Betulonic Acid C-28-Triphenylphosphonium Conjugates with Variable Alkyl Linker Length

(2019) Olga V. Tsepaeva et al.   Anti-Cancer Agents in Medicinal Chemistry

Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

(2018) Emanuela Martino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Delivery Systems for Birch-Bark Triterpenoids and Their Derivatives in Anticancer Research

(2018) Inese Mierina et al.   CURRENT MEDICINAL CHEMISTRY

Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives

(2018) Sulong Xiao et al.   MEDICINAL RESEARCH REVIEWS

Pentacyclic triterpenes: New tools to fight metabolic syndrome

(2018) Hitender Sharma et al.   PHYTOMEDICINE

Immunomodulatory activities of isolated compounds from the root-bark of Cussonia arborea

(2017) Abdulkabir Oladele Oladimeji et al.   PHARMACEUTICAL BIOLOGY

Anti-enterococcal activities of pentacyclic triterpenes

(2017) Dorota Wojnicz et al.   Advances in Clinical and Experimental Medicine

Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats

(2016) Putcharawipa Maneesai et al.   BMC Complementary and Alternative Medicine

Microtubule destabilising agents: far more than just antimitotic anticancer drugs

(2016) Darcy Bates et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets.

(2016) Daniela Bonofiglio et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Betulinic acid and the pharmacological effects of tumor suppression

(2016) Xia Zhang et al.   Molecular Medicine Reports

Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris

(2016) Chao-Min Wang et al.   MOLECULES

The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery

(2016) Emma C. Barnes et al.   NATURAL PRODUCT REPORTS

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases

(2016) MURTALA BINDAWA ISAH et al.   PARASITOLOGY

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol

(2015) D. E. Semenov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy

(2015) Mohamed Ali-Seyed et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of betulonic acid derivatives as antitumor agents

(2015) Sheng-Jie Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Taxane anticancer agents: a patent perspective

(2015) Iwao Ojima et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

(2015) Ionuţ Ledeţi et al.   MOLECULES

Triterpenes as Potentially Cytotoxic Compounds

(2015) Malwina Chudzik et al.   MOLECULES

Synthesis and the antineoplastic activity of imidazolides of betulonic acid

(2015) O. B. Kazakova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Synthesis of new betulinic acid–peptide conjugates and in vivo and in silico studies of the influence of peptide moieties on the triterpenoid core activity

(2015) Anastasiya I. Govdi et al.   MedChemComm

Anti-inflammatory effects of triterpenes and steroid compounds isolated from the stem bark of Hiptage benghalensis

(2015) Chin-Lin Hsu et al.   Journal of Functional Foods

Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview

(2014) Dorina Gheorgheosu et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis of triterpenoid triazine derivatives from allobetulone and betulonic acid with biological activities

(2014) Thuc Dinh Ngoc et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles

(2014) A. N. Antimonova et al.   CHEMISTRY OF NATURAL COMPOUNDS

Review on anti-tumor effect of triterpene acid compounds

(2014) Ping Lei et al.   Journal of Cancer Research and Therapeutics

Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice

(2014) Jine Yi et al.   Journal of Veterinary Science

Screening and Characterisation of Antimicrobial Properties of Semisynthetic Betulin Derivatives

(2014) Shafiul Haque et al.   PLoS One

Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery

(2014) Melessa Salem et al.   RSC Advances

Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells

(2013) Shengjie Yang et al.   Cancer Cell International

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

(2012) Muthu K. Shanmugam et al.   CANCER LETTERS

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation

(2012) Cristina A Dehelean et al.   Chemistry Central Journal

Alkylidene branched lupane derivatives: Synthesis and antitumor activity

(2012) René Csuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors

(2012) Xian-Huo Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Composition and antifungal activity of balsam from Liquidambar formosana Hance

(2012) Shih-Chang Chien et al.   HOLZFORSCHUNG

Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of Sp transcription factors and microRNA-27a:ZBTB10

(2012) Susanne U. Mertens-Talcott et al.   MOLECULAR CARCINOGENESIS

Chemical Constituents of the Ethyl Acetate Extract of Belamcanda chinensis (L.) DC Roots and Their Antitumor Activities

(2012) Mingchuan Liu et al.   MOLECULES

Lycopene, Tomato Products, and Prostate Cancer Incidence: A Review and Reassessment in the PSA Screening Era

(2012) Melissa Y. Wei et al.   Journal of Oncology

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel

(2011) Daniel L Lucetti et al.   Journal of Inflammation-London

Betulinic acid prevention ofd-galactosamine/lipopolysaccharide liver toxicity is triggered by activation of Bcl-2 and antioxidant mechanisms

(2011) Zhan-Wei Zheng et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Potential of Plant-Derived Natural Products in the Treatment of Leukemia and Lymphoma

(2010) David M. Lucas et al.   CURRENT DRUG TARGETS

Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties

(2010) Harish Kommera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Paclitaxel-Dependent Cell Lines Reveal a Novel Drug Activity

(2010) A. Ganguly et al.   MOLECULAR CANCER THERAPEUTICS

Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

(2010) Lasse Saaby et al.   PHYTOTHERAPY RESEARCH

The immunotropic activity of lupane and oleanane 2,3-seco-triterpenoids

(2010) L. V. Anikina et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids

(2010) O. B. Kazakova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling

(2010) Agnieszka Szuster-Ciesielska et al.   TOXICOLOGY

Efficient synthesis of the first betulonic acid–acetylene hybrids and their hepatoprotective and anti-inflammatory activity

(2009) Sergey F. Vasilevsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Betulinic Acid, a Natural Pentacyclic Triterpenoid, Prevents Abdominal Fat Accumulation in Mice Fed a High-Fat Diet

(2009) Célio L. de Melo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

(2009) Sebastian Jäger et al.   MOLECULES

Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy

(2009) Melanie Laszczyk   PLANTA MEDICA

Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol

(2009) Franziska B. Mullauer et al.   PLoS One

Vinflunine: A New Microtubule Inhibitor Agent

(2008) J. Bennouna et al.   CLINICAL CANCER RESEARCH

Oleanolic acid enhances insulin secretion in pancreatic β-cells

(2008) Tracy Teodoro et al.   FEBS LETTERS