Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery

Curcumin in various cancers

(2013) Adeeb Shehzad et al.   BIOFACTORS

Curcumin, a component of turmeric: From farm to pharmacy

(2013) Subash C. Gupta et al.   BIOFACTORS

Molecular mechanisms of curcumin action: Signal transduction

(2013) Adeeb Shehzad et al.   BIOFACTORS

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients

(2013) Masashi Kanai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

(2013) P. Kroon et al.   CANCER RESEARCH

Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy

(2013) Nattika Saengkrit et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Upregulation of extrinsic apoptotic pathway in curcumin-mediated antiproliferative effect on human pancreatic carcinogenesis

(2013) Mahmoud Youns et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel

(2013) Xi Chen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins

(2013) Sojung Park et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

CRM1 Is a Cellular Target of Curcumin: New Insights for the Myriad of Biological Effects of an Ancient Spice

(2013) Mingshan Niu et al.   TRAFFIC

Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

(2013) B S Vinod et al.   Cell Death & Disease

Curcumin conjugated gold nanoparticle synthesis and its biocompatibility

(2013) K. Sindhu et al.   RSC Advances

Mesoporous silica nanoparticles enhance the cytotoxicity of curcumin

(2013) Siddharth Jambhrunkar et al.   RSC Advances

Improving the anti-colon cancer activity of curcumin with biodegradable nano-micelles

(2013) Xiang Gao et al.   Journal of Materials Chemistry B

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance

(2012) Bing Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells

(2012) Ji Young Kim et al.   ARCHIVES OF ORAL BIOLOGY

Oxidative Metabolites of Curcumin Poison Human Type II Topoisomerases

(2012) Adam C. Ketron et al.   BIOCHEMISTRY

Curcumin's pre-incubation temperature affects its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme

(2012) Kuan-Nan Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular mechanisms of curcumin action: Gene expression

(2012) Shishir Shishodia   BIOFACTORS

Curcumin Encapsulation in Submicrometer Spray-Dried Chitosan/Tween 20 Particles

(2012) Martin G. O’Toole et al.   BIOMACROMOLECULES

RETRACTED: Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells

(2012) Shadan Ali et al.   CANCER LETTERS

Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration--A Clinical Pilot Study Including Assessment of Patient Acceptability

(2012) G. R. B. Irving et al.   Cancer Prevention Research

Fast dissolving eutectic compositions of curcumin

(2012) N. Rajesh Goud et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of Novel Biodegradable Methoxy Poly(ethylene glycol)–Zein Micelles for Effective Delivery of Curcumin

(2012) Satheesh Podaralla et al.   MOLECULAR PHARMACEUTICS

Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway

(2012) Li-da Guo et al.   PHYTOTHERAPY RESEARCH

Curcumin Induces Autophagy in ACC-MESO-1 Cells

(2012) Yoshikane Yamauchi et al.   PHYTOTHERAPY RESEARCH

Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway

(2012) Cheng-Liang Yang et al.   PLoS One

Vanillin and ferulic acid: not the major degradation products of curcumin

(2012) Odaine N. Gordon et al.   TRENDS IN MOLECULAR MEDICINE

The pharmacology of curcumin: is it the degradation products?

(2012) Liang Shen et al.   TRENDS IN MOLECULAR MEDICINE

Innovative Preparation of Curcumin for Improved Oral Bioavailability

(2011) Hiroki Sasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles

(2011) Aysegul Altunbas et al.   BIOMATERIALS

A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

(2011) Jeffrey D Altenburg et al.   BMC CANCER

Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030

(2011) L Lin et al.   BRITISH JOURNAL OF CANCER

A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors

(2011) Kah Jing Lim et al.   CANCER BIOLOGY & THERAPY

Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin

(2011) Zhen-Yu He et al.   CANCER INVESTIGATION

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

(2011) R. E. Carroll et al.   Cancer Prevention Research

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy

(2011) Wenzhuo Zhuang et al.   CANCER SCIENCE

Fast Dissolving Curcumin Cocrystals

(2011) Palash Sanphui et al.   CRYSTAL GROWTH & DESIGN

Coformulation of Doxorubicin and Curcumin in Poly(d,l-lactide-co-glycolide) Nanoparticles Suppresses the Development of Multidrug Resistance in K562 Cells

(2011) Ranjita Misra et al.   MOLECULAR PHARMACEUTICS

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

(2011) Purusotam Basnet et al.   MOLECULES

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Assessment in vitro of radioprotective efficacy of curcumin and resveratrol

(2011) Natividad Sebastià et al.   RADIATION MEASUREMENTS

Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials

(2010) Adeeb Shehzad et al.   ARCHIV DER PHARMAZIE

The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation

(2010) Chandana Mohanty et al.   BIOMATERIALS

Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

(2010) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer

(2010) Mathilde Bayet-Robert et al.   CANCER BIOLOGY & THERAPY

A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

(2010) Masashi Kanai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF

(2010) Shadan Ali et al.   CANCER RESEARCH

Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

(2010) J. Weissenberger et al.   CLINICAL CANCER RESEARCH

Steroid receptor and microRNA regulation in cancer

(2010) Michael A Tessel et al.   CURRENT OPINION IN ONCOLOGY

Preparation and characterization of intravenously injectable curcumin nanosuspension

(2010) Yan Gao et al.   DRUG DELIVERY

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin

(2010) Markus Griesser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

(2010) Leonid Bartik et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synthesis and Preliminary Characterization of Sulfamethazine-Theophylline Co-Crystal

(2010) JIE LU et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy

(2010) Chandana Mohanty et al.   Nanomedicine

Curcumin and Gemcitabine in Patients With Advanced Pancreatic Cancer

(2010) Ron Epelbaum et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells

(2009) Pratibha Mehta Luthra et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

Curcumin Binding to DNA and RNA

(2009) Shohreh Nafisi et al.   DNA AND CELL BIOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemopreventive potential of curcumin in prostate cancer

(2009) Marie-Hélène Teiten et al.   Genes and Nutrition

Photo-degradation of curcumin in the presence of TiO2 nanoparticles: Fundamentals and application

(2009) Umang Singh et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice

(2009) S.-L. Wu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effective Stabilization of Curcumin by Association to Plasma Proteins: Human Serum Albumin and Fibrinogen

(2009) Mandy H. M. Leung et al.   LANGMUIR

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects

(2008) S. K. Vareed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dendrimers as versatile platform in drug delivery applications

(2008) Sonke Svenson   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

(2008) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Hydrogels in drug delivery: Progress and challenges

(2008) Todd R. Hoare et al.   POLYMER