CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae

Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores

(2019) Nikolai Hecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Plasticity in Detoxification Gene Modules: The Preservation and Loss of the Pregnane X Receptor in Chondrichthyes Lineages

(2019) Elza S. S. Fonseca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

(2019) Zhipeng Ma et al.   NATURE

Independent losses of a xenobiotic receptor across teleost evolution

(2018) Marta Eide et al.   Scientific Reports

mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay

(2017) Jennifer L. Anderson et al.   PLoS Genetics

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor

(2015) Johanna Gräns et al.   AQUATIC TOXICOLOGY

Osteoblast-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Enhanced Bone Formation With Aberrant Mineralization

(2015) Kotaro Azuma et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently

(2015) Roger Lille-Langøy et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

(2015) Vanessa Delfosse et al.   Nature Communications

Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective

(2015) Yanbin Zhao et al.   Scientific Reports

Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis

(2014) X. Guo et al.   DEVELOPMENT

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

Role of Pregnane X Receptor and Aryl Hydrocarbon Receptor in Transcriptional Regulation of pxr, CYP2, and CYP3 Genes in Developing Zebrafish

(2014) Akira Kubota et al.   TOXICOLOGICAL SCIENCES

Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor

(2014) Cheryl A. Frye et al.   Frontiers in Cellular Neuroscience

BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors

(2013) C. T. Myers et al.   BLOOD

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System

(2013) Andrew R. Bassett et al.   Cell Reports

Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence

(2012) Katsuhide Igarashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The alternatively spliced murine pregnane X receptor isoform, mPXRΔ171–211 exhibits a repressive action

(2010) Marko Matic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption

(2010) Kotaro Azuma et al.   JOURNAL OF ENDOCRINOLOGY

The Major Human Pregnane X Receptor (PXR) Splice Variant, PXR.2, Exhibits Significantly Diminished Ligand-Activated Transcriptional Regulation

(2009) Y. S. Lin et al.   DRUG METABOLISM AND DISPOSITION

Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2

(2009) Yoshihiro Konno et al.   Pharmacogenetics and Genomics

Evolution of pharmacologic specificity in the pregnane X receptor

(2008) Sean Ekins et al.   BMC EVOLUTIONARY BIOLOGY