Age‐related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

(2021) Alexandra C. McQuattie-Pimentel et al.   JOURNAL OF CLINICAL INVESTIGATION

The ocular surface immune system through the eyes of aging

(2021) Jeremias G. Galletti et al.   Ocular Surface

Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state

(2020) Samira Mansouri et al.   Mucosal Immunology

Immune - Goblet cell interaction in the conjunctiva

(2020) Jehan Alam et al.   Ocular Surface

Age-specific incidence of allergic and non-allergic asthma

(2020) Johanna Pakkasela et al.   BMC Pulmonary Medicine

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

(2020) Raphaël Enaud et al.   Frontiers in Cellular and Infection Microbiology

Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response

(2020) William Foulsham et al.   AMERICAN JOURNAL OF PATHOLOGY

An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils

(2020) JodiRae DeDreu et al.   FASEB JOURNAL

Transient tear hyperosmolarity disrupts the neuroimmune homeostasis of the ocular surface and facilitates dry eye onset

(2020) Mauricio Guzmán et al.   IMMUNOLOGY

Ageing and the natural history of dry eye disease: A prospective registry-based cross-sectional study

(2020) Michael T.M. Wang et al.   Ocular Surface

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells

(2019) Fang Bian et al.   Mucosal Immunology

The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome

(2019) Claudia M. Trujillo-Vargas et al.   Ocular Surface

Sex difference in IgE sensitization associated with alcohol consumption in the general population

(2019) Daeyoung Roh et al.   Scientific Reports

Goblet cell associated antigen passages support the induction and maintenance of oral tolerance

(2019) Devesha H. Kulkarni et al.   Mucosal Immunology

Increased Susceptibility to Allergic Asthma with the Impairment of Respiratory Tolerance Caused by Psychological Stress

(2018) Tasuku Kawano et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Protective role of commensal bacteria in Sjögren Syndrome

(2018) Mahira Zaheer et al.   JOURNAL OF AUTOIMMUNITY

The mucosal surfaces of both eyes are immunologically linked by a neurogenic inflammatory reflex involving TRPV1 and substance P

(2018) Mauricio Guzmán et al.   Mucosal Immunology

Lifelong Maintenance of Oral Tolerance and Immunity Profiles in Mice Depends on Early Exposure to Antigen

(2018) E. F. Speziali et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Dry eye symptoms and impact on vision-related function across International Task Force guidelines severity levels in the United States

(2018) Laurie Barber et al.   BMC Ophthalmology

Tolerance Induction in Relation to the Eye

(2018) Igal Gery et al.   Frontiers in Immunology

Oral Tolerization with Mycobacterial Heat Shock Protein 65 Reduces Chronic Experimental Atherosclerosis in Aged Mice

(2017) Cecilia Wick et al.   GERONTOLOGY

Lung Homeostasis: Influence of Age, Microbes, and the Immune System

(2017) Clare M. Lloyd et al.   IMMUNITY

Mucosal immune tolerance at the ocular surface in health and disease

(2017) Jeremías G. Galletti et al.   IMMUNOLOGY

Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease

(2017) Flavia Barbosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TFOS DEWS II pathophysiology report

(2017) Anthony J. Bron et al.   Ocular Surface

Review: The function of regulatory T cells at the ocular surface

(2017) William Foulsham et al.   Ocular Surface

TFOS DEWS II Sex, Gender, and Hormones Report

(2017) David A. Sullivan et al.   Ocular Surface

Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome

(2017) Feeling Y. Chen et al.   PLoS One

Recipe for IBD: can we use food to control inflammatory bowel disease?

(2017) Mario Witkowski et al.   Seminars in Immunopathology

Cellular and Molecular Mechanisms of Anterior Chamber-Associated Immune Deviation (ACAID): What We Have Learned from Knockout Mice

(2017) Julie Vendomèle et al.   Frontiers in Immunology

Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly

(2017) Anshu Agrawal et al.   Frontiers in Immunology

Prevalence of Allergic Rhinitis Symptoms and Positive Skin-prick Test Results in Patients with Dry Eye

(2016) Alper Yenigun et al.   American Journal of Rhinology & Allergy

Innate immune responses in the ageing lung

(2016) D. M. Boe et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease

(2016) M. Guzmán et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye

(2016) Mauricio Guzmán et al.   EXPERIMENTAL EYE RESEARCH

Rhinitis in the Elderly

(2016) Alan P. Baptist et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

(2016) T G Coursey et al.   Mucosal Immunology

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

Interferon-gamma deficiency protects against aging-related goblet cell loss

(2016) Eugene A. Volpe et al.   Oncotarget

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

(2015) Kathryn A Knoop et al.   GUT

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Food Allergy

(2015) Jessica Savage et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Phenotype and function of nasal dendritic cells

(2015) H Lee et al.   Mucosal Immunology

Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice

(2014) Andrew J. McClellan et al.   AMERICAN JOURNAL OF PATHOLOGY

Extraorbital Lacrimal Gland Excision

(2014) William Stevenson et al.   CORNEA

Regulatory tone and mucosal immunity in asthma

(2014) Timothy J. Chapman et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

State of the art on food allergen immunotherapy: Oral, sublingual, and epicutaneous

(2014) Stacie M. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression

(2014) S. K. Chauhan et al.   JOURNAL OF IMMUNOLOGY

Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA

(2014) A. Agrawal et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state

(2014) S Prakash et al.   Mucosal Immunology

The Chemokine Receptor CCR7 Expressed by Dendritic Cells: A Key Player in Corneal and Ocular Surface Inflammation

(2014) Daniel R. Saban   Ocular Surface

The gut microbiota and inflammatory bowel disease

(2014) Katsuyoshi Matsuoka et al.   Seminars in Immunopathology

High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12 years of age – a population based cohort study

(2014) Anna Winberg et al.   Clinical and Translational Allergy

Spdef Null Mice Lack Conjunctival Goblet Cells and Provide a Model of Dry Eye

(2013) Christina K. Marko et al.   AMERICAN JOURNAL OF PATHOLOGY

Soluble antigen traffics rapidly and selectively from the corneal surface to the eye draining lymph node and activates T cells when codelivered with CpG oligonucleotides

(2013) Zexu Dang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cigarette smoking and inflammation revisited

(2013) Oren Rom et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Blocking CCR7 at the Ocular Surface Impairs the Pathogenic Contribution of Dendritic Cells in Allergic Conjunctivitis

(2012) Simona Schlereth et al.   AMERICAN JOURNAL OF PATHOLOGY

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Mucosal immunology of tolerance and allergy in the gastrointestinal tract

(2012) Lauren Steele et al.   IMMUNOLOGIC RESEARCH

Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model

(2012) J G Galletti et al.   Mucosal Immunology

Oral tolerance to food protein

(2012) O Pabst et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

B cell maintenance and function in aging

(2012) Igor Kogut et al.   SEMINARS IN IMMUNOLOGY

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

(2011) Sanae Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Elderly Subjects Have a Delayed Antibody Response and Prolonged Viraemia following Yellow Fever Vaccination: A Prospective Controlled Cohort Study

(2011) Anna H. Roukens et al.   PLoS One

Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca

(2011) Cintia S. De Paiva et al.   PLoS One

Allergic diseases in the elderly

(2011) Victoria Cardona et al.   Clinical and Translational Allergy

Anti-acid medication as a risk factor for food allergy

(2010) I. Pali-Schöll et al.   ALLERGY

Risk factors of new-onset asthma in adults: a population-based international cohort study

(2010) J. M. Antó et al.   ALLERGY

Effect of aging and oral tolerance on dendritic cell function

(2010) P.U. Simioni et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Food Allergy: Only a Pediatric Disease?

(2010) Susanne C. Diesner et al.   GERONTOLOGY

Elderly onset of primary Sjögren's syndrome: Clinical manifestations, serological features and oral/ocular diagnostic tests. Comparison with adult and young onset of the disease in a cohort of 336 Italian patients

(2010) Costantino Botsios et al.   JOINT BONE SPINE

Epithelial decision makers: in search of the 'epimmunome'

(2010) Mahima Swamy et al.   NATURE IMMUNOLOGY

Immune Privilege of Corneal Allografts

(2010) Jerry Y. Niederkorn et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

History and Physiology of Immune Privilege

(2010) Jerry Y. Niederkorn et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Preservatives in eyedrops: The good, the bad and the ugly

(2010) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Sjögren’s Syndrome-Like Ocular Surface Disease in Thrombospondin-1 Deficient Mice

(2009) Bruce Turpie et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of NKT cells in anterior chamber-associated immune deviation

(2009) Jerry Y Niederkorn   Expert Review of Clinical Immunology

Incidence of allergic diseases in an elderly population

(2009) M.T. Ventura et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+T cells during aging

(2009) Elaine Agius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice

(2009) C. S. De Paiva et al.   RHEUMATOLOGY

Immune privilege or privileged immunity?

(2008) J V Forrester et al.   Mucosal Immunology

Long-term Incidence of Dry Eye in an Older Population

(2008) Scot E. Moss et al.   OPTOMETRY AND VISION SCIENCE