Article
Medicine, General & Internal
Zilin Chen, Tian Zhang, Hio Tong Kam, Dijie Qiao, Wenwen Jin, Yajie Zhong, Minyi Zhou, Hongyan Zhou, Wai Po Chong, Wanjun Chen, Jun Chen
Summary: This study successfully induced antigen-specific Treg cells in a model of experimental autoimmune uveitis, alleviating ocular inflammation without compromising beneficial immune responses. The therapeutic effect was mediated by inhibiting specific T cell responses, while maintaining overall T cell immunity in the host.
Article
Biochemistry & Molecular Biology
Xuan Zhang, Cuiping Hu, Yajie Zhong, Dijie Qiao, Wei Chi, Huangxuan Shen, Waipo Chong
Summary: IL-24 is a multifunctional cytokine that regulates both immune cells and epithelial cells. In the study, IL-24 treatment was found to inhibit the progression of ocular inflammation in experimental autoimmune uveitis (EAU) mice and suppress cytokine production from pathogenic T cells. Additionally, IL-24 also suppressed the production of proinflammatory cytokines and chemokines from the inflamed retinas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yunwei Hu, Zuoyi Li, Guanyu Chen, Zhuang Li, Jun Huang, Haixiang Huang, Yanyan Xie, Qian Chen, Wenjie Zhu, Minzhen Wang, Jianping Chen, Wenru Su, Xiaoqing Chen, Dan Liang
Summary: This study investigated the anti-inflammatory effect of hydroxychloroquine (HCQ) on experimental autoimmune uveitis (EAU) and its mechanisms. The results showed that HCQ alleviates EAU by regulating the balance of T cells and improving retinal vascular endothelial cells (RVECs) dysfunction.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Amrita Basu, Ganesan Ramamoorthi, Gabriella Albert, Corey Gallen, Amber Beyer, Colin Snyder, Gary Koski, Mary L. Disis, Brian J. Czerniecki, Krithika Kodumudi
Summary: This review highlights the importance of T-H cells in cancer immunotherapy, discussing the regulation of different subtypes by various immune cells and the impact of contradictory signals on treatment outcomes. Understanding the complexities of CD4(+) T-H cells and balancing anti- vs pro-tumorigenic subtypes is crucial for designing effective immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Zhaoxin Jiang, Limei Sun, Xiaohu Ding, Ting Zhang, Songshan Li, Xiaoyan Ding
Summary: This study investigated the cytokine expression profile in the aqueous humor of patients with ocular toxocariasis. The findings suggest that Th1 and Th17 cytokine responses are not enhanced, while the cytokine status is polarized towards a Th2 response. The study also highlights the involvement of IL-5, IL-10, and IL-13 in the immunopathogenesis of ocular toxocariasis.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Chun Zhang, Xiuxing Liu, Jing Xiao, Fanwen Jiang, Luzhong Fa, Hui Jiang, Lin Zhou, Wenru Su, Zhuping Xu
Summary: Autoimmune uveitis is a non-infectious, inflammatory intraocular disease that affects the uveal and adjacent tissues, leading to visual loss. Activated γδ T cells play a significant role in the development of autoimmune uveitis by secreting pro-inflammatory factors and promoting Th17 cell responses. Understanding the mechanisms of γδ T cell involvement in different activation and disease states provides insights for the development of immunotherapies for treating autoimmune uveitis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yasuhiko Sato, Shoko Saito, Makiko Nakayama, Sunao Sugita, Akihiko Kudo, Hiroshi Keino
Summary: This study investigates the role of Nrf2 in the development of autoimmune uveoretinitis and suggests that Nrf2 deficiency exacerbates retinal inflammation, while activation of Nrf2 has a suppressive effect on the development of uveoretinitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E. Egwuagu
Summary: Interleukin-27 (IL-27) and Interleukin-35 (IL-35) have different roles in neuroinflammation and uveitis. IL-27 can suppress encephalomyelitis and autoimmune uveitis, while IL-35 may have a protective role in the retina by constitutive secretion to counteract persistent low-grade inflammation. Decreased expression of IL-35 leads to increased severity of uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Kathryne E. Marks, Deepak A. Rao
Summary: Pathologic T cell-B cell interactions play a crucial role in autoimmune diseases. Tph cells, a unique subset of T cells, have been identified in autoantibody-associated diseases, providing both B cell help and the ability to migrate to inflamed peripheral tissues. Understanding and tracking Tph cells are crucial for studying the pathogenesis and therapeutic strategies of autoimmune diseases.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Mi Zhang, Xiaomin Zhang
Summary: Autoimmune uveitis is a non-infectious intraocular condition that can lead to vision loss. Activated CD4+ T cells are associated with the destruction of photoreceptors in ocular autoimmune diseases. This review provides an overview of the role of CD4+ T cells in autoimmune uveitis and the development of medications targeting these cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Hiroyuki Yoshitomi, Hideki Ueno
Summary: The interactions between CD4(+)T cells and B cells are crucial for antibody responses and autoimmune diseases. Recent studies identified a new subset of CD4(+)B helper T cells called peripheral helper T (Tph) cells, which provide help to B cells in inflamed tissues and share some functions with Tfh cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Cell Biology
Ryan Salvador, Amy Zhang, Reiko Horai, Rachel R. Caspi
Summary: Studies on the contribution of microbiota to tissue-specific autoimmunity driven by T cells suggest the potential of microbiota-modulating therapies for treating ocular autoimmune diseases. Further exploration of translational animal models and integration of various datasets are needed to gain a better understanding of how microbiota modulate the immune system and contribute to disease onset. Deeper insight into these interactions may lead to more effective treatment interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xin Wang, Hongxuan Fan, Yongle Wang, Xufang Yin, Guangying Liu, Chong Gao, Xiaofeng Li, Bin Liang
Summary: This study aimed to compare changes in peripheral T cells in patients with RA affected with and without AF. Results showed that Th1 cell absolute number, Th17 cell absolute number, and Th1/Treg ratio were significantly associated with a higher risk of AF in RA patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yao Huang, Xin Ba, Liang Han, Hui Wang, Weiji Lin, Zhe Chen, Shenghao Tu
Summary: The interactions between T cells and B cells play a crucial role in antibody responses and the development of autoimmune diseases. A recent discovery of a distinct subset of T cells called peripheral helper T (Tph) cells in synovial fluid has shed light on their potential roles in autoimmune diseases. Tph cells express high levels of CXCL13, which drive the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately promoting the production of pathogenic autoantibodies. Further investigation of Tph cells may provide valuable insights into the pathogenesis of autoimmune diseases and identify novel therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jun Huang, Zhuang Li, Yunwei Hu, Guanyu Chen, Zuoyi Li, Yanyan Xie, Haixiang Huang, Wenru Su, Xiaoqing Chen, Dan Liang
Summary: Azithromycin alleviates experimental autoimmune uveitis (EAU) in mice by regulating the balance between T effector cells (Teff) and T regulatory cells (Treg) through the mTOR signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)