Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

(2019) Rui Gao et al.   eLife

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

(2019) Allison J. Schaser et al.   Scientific Reports

Oxidative Stress in Spinocerebellar Ataxia Type 7 Is Associated with Disease Severity

(2018) Y. Torres-Ramos et al.   CEREBELLUM

HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130

(2018) Anja Göder et al.   Nature Communications

A Patient-Derived Cellular Model for Huntington's Disease Reveals Phenotypes at Clinically Relevant CAG Lengths

(2018) Claudia Lin-Kar Hung et al.   MOLECULAR BIOLOGY OF THE CELL

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

(2017) Nathaniel W Holton et al.   Jove-Journal of Visualized Experiments

DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases

(2016) Conceição Bettencourt et al.   ANNALS OF NEUROLOGY

A unifying mechanism in neurodegeneration

(2016) Christopher A. Ross et al.   NATURE

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress

(2015) Anna Campalans et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM prevents DSB formation by coordinating SSB repair and cell cycle progression

(2015) Svetlana V. Khoronenkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

(2015) Rui Gao et al.   PLoS Genetics

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

(2015) Arpita Chatterjee et al.   PLoS Genetics

Modulation of the age at onset in spinocerebellar ataxia by CAG tracts in various genes

(2014) Sophie Tezenas du Montcel et al.   BRAIN

Polyglutamine (PolyQ) Diseases: Genetics to Treatments

(2014) Hueng-Chuen Fan et al.   CELL TRANSPLANTATION

DNA glycosylases search for and remove oxidized DNA bases

(2013) Susan S. Wallace   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Role of oxidative DNA damage in mitochondrial dysfunction and Huntington’s disease pathogenesis

(2013) Sylvette Ayala-Peña   FREE RADICAL BIOLOGY AND MEDICINE

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

The Development of a Monoclonal Antibody Recognizing the Drosophila melanogaster Phosphorylated Histone H2A Variant (γ-H2AV)

(2013) Cathleen M. Lake et al.   G3-Genes Genomes Genetics

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

(2011) Lee Kamentsky et al.   BIOINFORMATICS

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection

(2010) Y. Xue et al.   PROTEIN ENGINEERING DESIGN & SELECTION

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome

(2009) Rong Guo et al.   METHODS

Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6

(2008) Christoph Globas et al.   MOVEMENT DISORDERS

Spinocerebellar ataxia types 1, 2, 3, and 6: Disease severity and nonataxia symptoms

(2008) T. Schmitz-Hubsch et al.   NEUROLOGY