Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9

AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In Vivo

(2020) Sara K. Powell et al.   MOLECULAR THERAPY

Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

(2020) Sripriya Ravindra Kumar et al.   NATURE METHODS

Comparison of high-dose intracisterna magna and lumbar puncture intrathecal delivery of AAV9 in mice to treat neuropathies

(2020) Rachel M. Bailey et al.   BRAIN RESEARCH

A road less travelled: the centenary of cisterna magna puncture

(2020) Bart Lutters et al.   BRAIN

CNS transduction benefits of AAV-PHP.eB over AAV9 are dependent on administration route and mouse strain.

(2020) Sophie N. Mathiesen et al.   Molecular Therapy-Methods & Clinical Development

Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy

(2019) Diptaman Chatterjee et al.   Journal of Parkinsons Disease

The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier

(2019) Juliette Hordeaux et al.   MOLECULAR THERAPY

Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

(2019) Eloise Hudry et al.   NEURON

AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

(2019) William A. Liguore et al.   MOLECULAR THERAPY

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

(2019) Qin Huang et al.   PLoS One

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

(2019) Marcus Davidsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More expansive gene transfer to the rat CNS: AAV PHP.EB vector dose–response and comparison to AAV PHP.B

(2018) Robert D. Dayton et al.   GENE THERAPY

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

Two breakthrough gene-targeted treatments for spinal muscular atrophy: challenges remain

(2018) Charlotte J. Sumner et al.   JOURNAL OF CLINICAL INVESTIGATION

The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice

(2018) Juliette Hordeaux et al.   MOLECULAR THERAPY

Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy

(2018) Rachel M. Bailey et al.   Molecular Therapy-Methods & Clinical Development

Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

(2018) Michael J. Castle et al.   Science Advances

Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders

(2017) K Bey et al.   GENE THERAPY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

AAVR: A Multi-Serotype Receptor for AAV

(2016) Candace Summerford et al.   MOLECULAR THERAPY

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats

(2015) Kasey L Jackson et al.   Molecular Therapy-Methods & Clinical Development

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

(2013) S J Gray et al.   GENE THERAPY

Identification of the Galactose Binding Domain of the Adeno-Associated Virus Serotype 9 Capsid

(2012) C. L. Bell et al.   JOURNAL OF VIROLOGY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY