6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β)

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

(2020) Peng-De Lu et al.   Chinese Medicine

Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review

(2019) M. Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of bacteria in the inflammatory bowel disease development: a narrative review

(2018) Taher Azimi et al.   APMIS

A Versatile New Model of Chemically Induced Chronic Colitis Using an Outbred Murine Strain

(2018) Monica Barone et al.   Frontiers in Microbiology

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

(2017) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis

(2017) Derrick D Eichele et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Protective Effect of Daikenchuto on Dextran Sulfate Sodium-Induced Colitis in Mice

(2017) Takaharu Matsunaga et al.   Gastroenterology Research and Practice

Regulation of Inflammation and T Cells by Glycogen Synthase Kinase-3: Links to Mood Disorders

(2017) Eleonore Beurel   NEUROIMMUNOMODULATION

DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells

(2016) Phoebe Zapanta Trio et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging

(2016) Mukesh K. Pandey et al.   Theranostics

Antibacterial Activities of Wasabi against Escherichia coli O157:H7 and Staphylococcus aureus

(2016) Zhongjing Lu et al.   Frontiers in Microbiology

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates

(2015) Doris Vandeputte et al.   GUT

Molecular dynamics simulation studies of GSK-3β ATP competitive inhibitors: understanding the factors contributing to selectivity

(2015) Minhajul Arfeen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

(2015) Ryuichi Okamoto et al.   JOURNAL OF GASTROENTEROLOGY

Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

(2015) Gaurav Kumar et al.   TUMOR BIOLOGY

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease?

(2015) Niloo Karunaweera et al.   Frontiers in Molecular Neuroscience

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

(2014) Séverine Vermeire et al.   LANCET

Wasabi-Derived 6-(Methylsulfinyl)Hexyl Isothiocyanate Induces Apoptosis in Human Breast Cancer by Possible Involvement of the NF-κB Pathways

(2014) Yoko Fuke et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Impact of psychological stress on irritable bowel syndrome

(2014) Hong-Yan Qin   WORLD JOURNAL OF GASTROENTEROLOGY

Histological evaluation in ulcerative colitis

(2014) T. C. DeRoche et al.   Gastroenterology Report

The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases

(2013) Vassilis Valatas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells

(2013) Hideaki Yamaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Vedolizumab for the Treatment of IBD: A Selective Therapeutic Approach Targeting Pathogenic a4b7 Cells

(2013) Manol Jovani et al.   CURRENT DRUG TARGETS

Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia

(2013) Adam R. Cole   FEBS Journal

Regulatory Role of GSK-3βon NF-κB, Nitric Oxide, and TNF-αin Group A Streptococcal Infection

(2013) Yu-Tzu Chang et al.   MEDIATORS OF INFLAMMATION

Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens

(2012) Ricarda Cortés-Vieyra et al.   Journal of Inflammation-London

Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon

(2012) Hamed Laroui et al.   PLoS One

Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonicaMatsum)

(2011) Jun YOSHIDA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates

(2011) Y. Zhang   CARCINOGENESIS

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Role of the endothelium in inflammatory bowel diseases

(2011) Walter E Cromer   WORLD JOURNAL OF GASTROENTEROLOGY

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity

(2009) Toshiro Noshita et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovering NF- B

(2009) D. Baltimore   Cold Spring Harbor Perspectives in Biology

ASEDock-Docking Based on Alpha Spheres and Excluded Volumes

(2008) Junichi Goto et al.   Journal of Chemical Information and Modeling