Upregulation of CCR4 in activated CD8 + T cells indicates enhanced lung homing in patients with severe acute SARS‐CoV‐2 infection

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

(2020) Hong-Yi Zheng et al.   Cellular & Molecular Immunology

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

(2020) Fan Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Decreased B cells on admission was associated with prolonged viral RNA shedding from respiratory tract in Coronavirus Disease 2019: a case control study

(2020) Shaorui Hao et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study

(2020) Jianbo Tian et al.   LANCET ONCOLOGY

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

(2020) Irani Thevarajan et al.   NATURE MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

The clinical course and its correlated immune status in COVID-19 pneumonia

(2020) Ruyuan He et al.   JOURNAL OF CLINICAL VIROLOGY

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

Immunological and inflammatory profiles in mild and severe cases of COVID-19

(2020) Jin-Wen Song et al.   Nature Communications

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

Decreased T cell populations contribute to the increased severity of COVID-19

(2020) Rui Liu et al.   CLINICA CHIMICA ACTA

Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

(2020) Lila Bouadma et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Natural killer cell immunotypes related to COVID-19 disease severity

(2020) Christopher Maucourant et al.   Science Immunology

NKG2A is a NK cell exhaustion checkpoint for HCV persistence

(2019) Chao Zhang et al.   Nature Communications

Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity

(2019) Tabea Haug et al.   Frontiers in Immunology

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

(2019) Andrea Cossarizza et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

(2017) Paola Fisicaro et al.   NATURE MEDICINE

Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection

(2017) Marcia Bellon et al.   Viruses-Basel

Human CD56dimCD16dim Cells As an Individualized Natural Killer Cell Subset

(2017) Mathieu Amand et al.   Frontiers in Immunology

HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation

(2016) K. Sugata et al.   CANCER RESEARCH

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Magnitude and Kinetics of CD8 + T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

(2015) Zaza M. Ndhlovu et al.   IMMUNITY

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

(2014) R. Channappanavar et al.   JOURNAL OF VIROLOGY

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection

(2009) J. Chen et al.   JOURNAL OF VIROLOGY