Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

(2015) James Ozanne et al.   BIOCHEMICAL JOURNAL

Repeated Administration of Bone Marrow-Derived Cells Prevents Disease Progression in Experimental Silicosis

(2015) Miquéias Lopes-Pacheco et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

P633 REGULATION OF LIVER FIBROSIS BY TUNING M2 MACROPHAGE POLARIZATION THROUGH IL-4Rα INHIBITION

(2014) S.-Y. Weng et al.   JOURNAL OF HEPATOLOGY

Effectiveness of dasatinib in accelerated-phase chronic myeloid leukemia with p190 BCR-ABL1 and a second Philadelphia chromosome

(2014) Karen E. Rabenau et al.   Cancer Genetics

Macrophage Heterogeneity in Respiratory Diseases

(2013) Carian E. Boorsma et al.   MEDIATORS OF INFLAMMATION

Dasatinib inhibits proinflammatory functions of mature human neutrophils

(2012) K. Futosi et al.   BLOOD

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

Protein tyrosine kinases in neutrophil activation and recruitment

(2011) Alexander Zarbock et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dasatinib as a Single Agent in Triple-Negative Breast Cancer: Results of an Open-Label Phase 2 Study

(2011) R. S. Finn et al.   CLINICAL CANCER RESEARCH

The Non-phagocytic Route of Collagen Uptake

(2011) Daniel H. Madsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis

(2010) T. Maron-Gutierrez et al.   EUROPEAN RESPIRATORY JOURNAL

The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo

(2010) Kate Vandyke et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeting non-malignant disorders with tyrosine kinase inhibitors

(2010) Friedrich Grimminger et al.   NATURE REVIEWS DRUG DISCOVERY

The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo

(2009) M.-P. Gratacap et al.   BLOOD

Dasatinib inhibits the secretion of TNF-α following TLR stimulation in vitro and in vivo

(2009) Cara K. Fraser et al.   EXPERIMENTAL HEMATOLOGY

Systemic Inhibition of NF-κB Activation Protects from Silicosis

(2009) Michelangelo Di Giuseppe et al.   PLoS One

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Dasatinib suppresses in vitro natural killer cell cytotoxicity

(2008) S. J. Blake et al.   BLOOD

The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils

(2008) M. Kneidinger et al.   BLOOD

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION