Effect of Water pH on the Uptake of Acidic (Ibuprofen) and Basic (Propranolol) Drugs in a Fish Gill Cell Culture Model

Mechanisms of pH-Dependent Uptake of Ionizable Organic Chemicals by Fish from Oil Sands Process-Affected Water (OSPW)

(2020) Markus Brinkmann et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

ABC transporters in gills of rainbow trout (Oncorhynchus mykiss)

(2020) Christian Kropf et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos

(2019) Raffael Alois Willi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Waterborne pharmaceutical uptake and toxicity is modified by pH and dissolved organic carbon in zebrafish

(2019) Derek Alsop et al.   AQUATIC TOXICOLOGY

Biomonitoring of pesticides, pharmaceuticals and illicit drugs in a freshwater invertebrate to estimate toxic or effect pressure

(2019) Thomas H. Miller et al.   ENVIRONMENT INTERNATIONAL

Antidepressants in Surface Waters: Fluoxetine Influences Mosquitofish Anxiety-Related Behavior at Environmentally Relevant Levels

(2019) Jake M. Martin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Uptake and effects of the beta‐adrenergic agonist salbutamol in fish: supporting evidence for the fish plasma model

(2019) Mirco Weil et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Glucocorticoid mixtures of fluticasone propionate, triamcinolone acetonide and clobetasol propionate induce additive effects in zebrafish embryos

(2019) Raffael Alois Willi et al.   JOURNAL OF HAZARDOUS MATERIALS

Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis

(2019) W. Casan Scott et al.   CHEMOSPHERE

Pharmacology beyond the patient – The environmental risks of human drugs

(2019) Lina Gunnarsson et al.   ENVIRONMENT INTERNATIONAL

Recommendations For Improving Methods And Models For Aquatic Hazard Assessment Of Ionizable Organic Chemicals

(2019) Beate I. Escher et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Treatment with synthetic glucocorticoid impairs bone metabolism, as revealed by in vivo imaging of osteoblasts and osteoclasts in medaka fish

(2019) Yuki Azetsu et al.   BIOMEDICINE & PHARMACOTHERAPY

Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds

(2019) Jelena Dragojević et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Comprehensive substrate characterization of 22 antituberculosis drugs for multiple solute carrier (SLC) uptake transporters, in vitro

(2018) Md Masud Parvez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influence of pH on the uptake and toxicity of β-blockers in embryos of zebrafish, Danio rerio

(2018) Lisa Bittner et al.   AQUATIC TOXICOLOGY

Cellular Uptake Kinetics of Neutral and Charged Chemicals in in Vitro Assays Measured by Fluorescence Microscopy

(2018) Fabian C. Fischer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A review of the pharmaceutical exposome in aquatic fauna

(2018) Thomas H. Miller et al.   ENVIRONMENTAL POLLUTION

Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology

(2018) Bryan W Brooks   Conservation Physiology

The Use of Molecular Descriptors To Model Pharmaceutical Uptake by a Fish Primary Gill Cell Culture Epithelium

(2018) Elisabeth D. Chang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Prediction of bioconcentration factors in fish and invertebrates using machine learning

(2018) Thomas H. Miller et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

(2018) Samuel Fekadu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Generic physiologically-based toxicokinetic modelling for fish: Integration of environmental factors and species variability

(2018) Audrey Grech et al.   SCIENCE OF THE TOTAL ENVIRONMENT

QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test

(2018) Nils Klüver et al.   AQUATIC TOXICOLOGY

Environmental impact of estrogens on human, animal and plant life: A critical review

(2017) Muhammad Adeel et al.   ENVIRONMENT INTERNATIONAL

ECOdrug: a database connecting drugs and conservation of their targets across species

(2017) Bas Verbruggen et al.   NUCLEIC ACIDS RESEARCH

Baseline toxicity and ion-trapping models to describe the pH-dependence of bacterial toxicity of pharmaceuticals

(2017) Andreas Baumer et al.   Environmental Science-Processes & Impacts

Testing the “read-across hypothesis” by investigating the effects of ibuprofen on fish

(2016) Alpa Patel et al.   CHEMOSPHERE

Alternative approaches to vertebrate ecotoxicity tests in the 21st century: A review of developments over the last 2 decades and current status

(2016) Adam Lillicrap et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities

(2016) James M. Armitage et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Procedures for the reconstruction, primary culture and experimental use of rainbow trout gill epithelia

(2016) Sabine Schnell et al.   Nature Protocols

Dissolved organic carbon from the upper Rio Negro protects zebrafish (Danio rerio) against ionoregulatory disturbances caused by low pH exposure

(2016) Rafael M. Duarte et al.   Scientific Reports

Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish

(2016) Luigi Margiotta-Casaluci et al.   Scientific Reports

A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: Evidence for passive and facilitated transport

(2015) Lucy C. Stott et al.   AQUATIC TOXICOLOGY

High levels of interspecific gene flow in an endemic cichlid fish adaptive radiation from an extreme lake environment

(2015) Antonia G. P. Ford et al.   MOLECULAR ECOLOGY

pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion

(2015) Yi Zheng et al.   PHARMACEUTICAL RESEARCH

Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges

(2015) Marja Lena Boström et al.   WATER RESEARCH

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

(2014) Dennis Smith et al.   MOLECULAR PHARMACEUTICS

Quantitative Cross-Species Extrapolation between Humans and Fish: The Case of the Anti-Depressant Fluoxetine

(2014) Luigi Margiotta-Casaluci et al.   PLoS One

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The significance of acid/base properties in drug discovery

(2012) David T. Manallack et al.   CHEMICAL SOCIETY REVIEWS

Predicting Fish Acute Toxicity Using a Fish Gill Cell Line-Based Toxicity Assay

(2012) Katrin Tanneberger et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish

(2012) James M. Armitage et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss)

(2010) Stephan Fischer et al.   AQUATIC TOXICOLOGY

Activity-Based Concept for Transport and Partitioning of Ionizing Organics

(2010) Stefan Trapp et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry

(2009) Stewart F. Owen et al.   AQUATIC TOXICOLOGY

METHODS FOR ESTIMATING THE BIOCONCENTRATION FACTOR OF IONIZABLE ORGANIC CHEMICALS

(2009) Wenjing Fu et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Critical evaluation of buffering solutions for pKadetermination by capillary electrophoresis

(2008) Elisabet Fuguet et al.   ELECTROPHORESIS

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

(2008) Lina Gunnarsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY