Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities

Equilibrium Sorption of Structurally Diverse Organic Ions to Bovine Serum Albumin

(2016) Luise Henneberger et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Which Molecular Features Affect the Intrinsic Hepatic Clearance Rate of Ionizable Organic Chemicals in Fish?

(2016) Yi Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Root Uptake of Pharmaceuticals and Personal Care Product Ingredients

(2016) Elizabeth L. Miller et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss)

(2016) Daniel M. Consoer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The origin and evolution of assessment criteria for persistent, bioaccumulative and toxic (PBT) chemicals and persistent organic pollutants (POPs)

(2016) Michael Matthies et al.   Environmental Science-Processes & Impacts

A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: Evidence for passive and facilitated transport

(2015) Lucy C. Stott et al.   AQUATIC TOXICOLOGY

Development and Evaluation of a Database of Dietary Bioaccumulation Test Data for Organic Chemicals in Fish

(2015) Jon A. Arnot et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Somatic and gastrointestinal in vivo biotransformation rates of hydrophobic chemicals in fish

(2015) Justin C. Lo et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset

(2015) Jason P. Berninger et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, in fathead minnows

(2015) John W. Nichols et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

(2015) Sanjay K. Nigam et al.   PHYSIOLOGICAL REVIEWS

Plant uptake of pharmaceutical and personal care products from recycled water and biosolids: a review

(2015) Xiaoqin Wu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Review of existing terrestrial bioaccumulation models and terrestrial bioaccumulation modeling needs for organic chemicals

(2015) Frank APC Gobas et al.   Integrated Environmental Assessment and Management

Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout (Oncorhynchus mykiss)

(2014) Daniel M. Consoer et al.   AQUATIC TOXICOLOGY

Cellular transport of microcystin-LR in rainbow trout (Oncorhynchus mykiss) across the intestinal wall: Possible involvement of multidrug resistance-associated proteins

(2014) Flavia Bieczynski et al.   AQUATIC TOXICOLOGY

Current advances on ABC drug transporters in fish

(2014) Till Luckenbach et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models

(2014) Carla A. Ng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Irrigation of Root Vegetables with Treated Wastewater: Evaluating Uptake of Pharmaceuticals and the Associated Human Health Risks

(2014) Tomer Malchi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Acidic and Basic Drugs in Medicinal Chemistry: A Perspective

(2014) Paul S. Charifson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prediction of Phospholipid–Water Partition Coefficients of Ionic Organic Chemicals Using the Mechanistic Model COSMOmic

(2014) Kai Bittermann et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

(2014) Dennis Smith et al.   MOLECULAR PHARMACEUTICS

Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems

(2014) K. E. Arnold et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Quantitative Cross-Species Extrapolation between Humans and Fish: The Case of the Anti-Depressant Fluoxetine

(2014) Luigi Margiotta-Casaluci et al.   PLoS One

Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide, Oatp1d1 (Slco1d1)

(2014) Marta Popovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular cloning and functional characterization of a rainbow trout liver Oatp

(2014) Konstanze Steiner et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Hepatic Efflux Transporters in Regulating Systemic and Hepatocyte Exposure to Xenobiotics

(2013) Nathan D. Pfeifer et al.   Annual Review of Pharmacology and Toxicology

Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos

(2013) Stephan Fischer et al.   BMC BIOLOGY

Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1–5days

(2013) Jasna Bogdanska et al.   CHEMOSPHERE

Estimation of the Acid Dissociation Constant of Perfluoroalkyl Carboxylic Acids through an Experimental Investigation of their Water-to-Air Transport

(2013) Lena Vierke et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Structure-Based Investigation on the Interaction of Perfluorinated Compounds with Human Liver Fatty Acid Binding Protein

(2013) Lianying Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A benchmarking method to measure dietary absorption efficiency of chemicals by fish

(2013) Ruiyang Xiao et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions

(2013) Kristin A. Connors et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Bioaccumulation of triclosan and triclocarban in plants grown in soils amended with municipal dewatered biosolids

(2013) Ryan S. Prosser et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Molecular Characterization of Zebrafish Oatp1d1 (Slco1d1), a Novel Organic Anion-transporting Polypeptide

(2013) Marta Popovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine

(2012) Margaret O. James et al.   AQUATIC TOXICOLOGY

Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows

(2012) Theodore W. Valenti et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effect of Sodium and Calcium Cations on the Ion-Exchange Affinity of Organic Cations for Soil Organic Matter

(2012) Steven Droge et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish

(2012) James M. Armitage et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Predicting the oral uptake efficiency of chemicals in mammals: Combining the hydrophilic and lipophilic range

(2012) Isabel A. O'Connor et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Renal Elimination of Perfluorocarboxylates (PFCAs)

(2011) Xing Han et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Optimal choice of pH for toxicity and bioaccumulation studies of ionizing organic chemicals

(2011) Cecilie Rendal et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of the antihistamine diphenhydramine on selected aquatic organisms

(2011) Jason P. Berninger et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Equilibrium sampling of environmental pollutants in fish: Comparison with lipid-normalized concentrations and homogenization effects on chemical activity

(2011) Annika Jahnke et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Using the fish plasma model for comparative hazard identification for pharmaceuticals in the environment by extrapolation from human therapeutic data

(2011) René Schreiber et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys

(2011) Shu-Ching Chang et al.   REPRODUCTIVE TOXICOLOGY

Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

(2011) Maria Sundström et al.   REPRODUCTIVE TOXICOLOGY

Simulation of chemical metabolism for fate and hazard assessment. III. New developments of the bioconcentration factor base-line model

(2011) S. Dimitrov et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Comparing laboratory and field measured bioaccumulation endpoints

(2011) Lawrence P Burkhard et al.   Integrated Environmental Assessment and Management

Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

(2011) Robert C Buck et al.   Integrated Environmental Assessment and Management

Development of a Fluorescence Model for the Binding of Medium- to Long-Chain Perfluoroalkyl Acids to Human Serum Albumin Through a Mechanistic Evaluation of Spectroscopic Evidence

(2010) Paul C. Hebert et al.   ANALYTICAL CHEMISTRY

Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss)

(2010) Stephan Fischer et al.   AQUATIC TOXICOLOGY

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

The influence of gill and liver metabolism on the predicted bioconcentration of three pharmaceuticals in fish

(2010) C.F. Gomez et al.   CHEMOSPHERE

MRP proteins as potential mediators of heavy metal resistance in zebrafish cells

(2010) Yong Long et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Activity-Based Concept for Transport and Partitioning of Ionizing Organics

(2010) Stefan Trapp et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Noncovalent Interactions of Long-Chain Perfluoroalkyl Acids with Serum Albumin

(2010) Heather N. Bischel et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A multimedia activity model for ionizable compounds: Validation study with 2,4-dichlorophenoxyacetic acid, aniline, and trimethoprim

(2010) Antonio Franco et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

An unexpected challenge: ionizable compounds in the REACH chemical space

(2010) Antonio Franco et al.   INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of Cellular Uptake of Perfluorooctanoate via Organic Anion-Transporting Polypeptide 1A2, Organic Anion Transporter 4, and Urate Transporter 1 for Their Potential Roles in Mediating Human Renal Reabsorption of Perfluorocarboxylates

(2010) Ching-Hui Yang et al.   TOXICOLOGICAL SCIENCES

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

Binding of Perfluorocarboxylates to Serum Albumin: A Comparison of Analytical Methods

(2009) Laura A. MacManus-Spencer et al.   ANALYTICAL CHEMISTRY

A pharmacokinetic evaluation of five H1antagonists after an oral and intravenous microdose to human subjects

(2009) Ajay Madan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): Phylogenetic analysis and tissue distribution

(2009) Marta Popovic et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss)

(2009) Jovica Lončar et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

METHODS FOR ESTIMATING THE BIOCONCENTRATION FACTOR OF IONIZABLE ORGANIC CHEMICALS

(2009) Wenjing Fu et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The presence of pharmaceuticals in the environment due to human use – present knowledge and future challenges

(2009) Klaus Kümmerer   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Total body burden and tissue distribution of polyfluorinated compounds in harbor seals (Phoca vitulina) from the German Bight

(2009) Lutz Ahrens et al.   MARINE POLLUTION BULLETIN

The acid–base profile of a contemporary set of drugs: implications for drug discovery

(2009) D.T. Manallack   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Revisiting Bioaccumulation Criteria for POPs and PBT Assessments

(2009) Frank A.P.C. Gobas et al.   Integrated Environmental Assessment and Management

Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin

(2008) Yan-Min Chen et al.   ARCHIVES OF TOXICOLOGY

Are PFCAs Bioaccumulative? A Critical Review and Comparison with Regulatory Criteria and Persistent Lipophilic Compounds

(2008) Jason M. Conder et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

ESTIMATION OF THE SOIL–WATER PARTITION COEFFICIENT NORMALIZED TO ORGANIC CARBON FOR IONIZABLE ORGANIC CHEMICALS

(2008) Antonio Franco et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

INFLUENCE OF SOIL pH ON THE SORPTION OF IONIZABLE CHEMICALS: MODELING ADVANCES

(2008) Antonio Franco et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans

(2008) Geary W. Olsen et al.   TOXICOLOGY

Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats

(2008) X HAN et al.   TOXICOLOGY LETTERS

Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)

(2007) Matthew J. Winter et al.   AQUATIC TOXICOLOGY

The pKaValues of PFOA and Other Highly Fluorinated Carboxylic Acids

(2007) Kai-Uwe Goss   ENVIRONMENTAL SCIENCE & TECHNOLOGY

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO