Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues

Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex

(2020) Bin Zhao et al.   BIOCHEMISTRY

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

(2020) Hui Wang et al.   MOLECULAR CELL

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

(2020) Dirksen E. Bussiere et al.   Nature Chemical Biology

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome

(2020) Hong Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex

(2020) Mary E. Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

(2020) Chun-wa Chung et al.   ACS Chemical Biology

Chain reactions: molecular mechanisms of RBR ubiquitin ligases

(2020) Thomas R. Cotton et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

(2020) Mikołaj Słabicki et al.   NATURE

Rational discovery of molecular glue degraders via scalable chemical profiling

(2020) Cristina Mayor-Ruiz et al.   Nature Chemical Biology

Structure and dynamics of the ASB9 CUL-RING E3 Ligase

(2020) Ryan J. Lumpkin et al.   Nature Communications

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

(2020) Zhuoyao Chen et al.   Open Biology

N-degron and C-degron pathways of protein degradation

(2019) Alexander Varshavsky   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anaphase-promoting complex/cyclosome regulates RdDM activity by degrading DMS3 in Arabidopsis

(2019) Songxiao Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

(2019) Michael J. Roy et al.   ACS Chemical Biology

HECT E3 Ligases: A Tale With Multiple Facets

(2019) Janine Weber et al.   Frontiers in Physiology

Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

(2019) William Farnaby et al.   Nature Chemical Biology

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

(2019) Zhuoyao Chen et al.   STRUCTURE

Bifunctional chemical probes inducing protein–protein interactions

(2019) Chiara Maniaci et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

(2019) Shuai Qiao et al.   MOLECULAR CELL

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

(2019) Tyler B. Faust et al.   Nature Chemical Biology

Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820

(2019) Xinlin Du et al.   STRUCTURE

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

(2019) Sarah V. Faull et al.   Nature Communications

Structure-Based Design of a Macrocyclic PROTAC

(2019) Andrea Testa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions

(2019) David Barford   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons

(2018) Itay Koren et al.   CELL

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

(2018) Kuan-Chuan Pao et al.   NATURE

Plasticity in binding confers selectivity in ligand-induced protein degradation

(2018) Radosław P. Nowak et al.   Nature Chemical Biology

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway

(2018) Cheng Dong et al.   Nature Chemical Biology

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase

(2018) Domniţa-Valeria Rusnac et al.   MOLECULAR CELL

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

(2018) Quinlan L. Sievers et al.   SCIENCE

The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation

(2018) Michael Sebastian Ostertag et al.   STRUCTURE

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

(2017) Mary E. Matyskiela et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective degradation of splicing factor CAPERα by anticancer sulfonamides

(2017) Taisuke Uehara et al.   Nature Chemical Biology

Structural basis of PROTAC cooperative recognition for selective protein degradation

(2017) Morgan S Gadd et al.   Nature Chemical Biology

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

(2017) Shun-Jia Chen et al.   SCIENCE

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

(2017) Teresa A.F. Cardote et al.   STRUCTURE

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

(2016) Mary E. Matyskiela et al.   NATURE

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

(2016) Simone Cavadini et al.   NATURE

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

(2016) Georg Petzold et al.   NATURE

Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

(2015) Emil Bulatov et al.   BIOCHEMICAL JOURNAL

Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

(2013) Jemima C. Thomas et al.   BIOCHEMISTRY

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Structural Basis for a Reciprocal Regulation between SCF and CSN

(2012) Radoslav I. Enchev et al.   Cell Reports

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL