Rational discovery of molecular glue degraders via scalable chemical profiling
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Rational discovery of molecular glue degraders via scalable chemical profiling
Authors
Keywords
-
Journal
Nature Chemical Biology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-08-04
DOI
10.1038/s41589-020-0594-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
- (2020) Kurt M. Reichermeier et al. MOLECULAR CELL
- Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
- (2019) Cristina Mayor-Ruiz et al. MOLECULAR CELL
- Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
- (2019) Tyler B. Faust et al. Nature Chemical Biology
- Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820
- (2019) Xinlin Du et al. STRUCTURE
- Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
- (2019) Tabitha C. Ting et al. Cell Reports
- Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
- (2019) Dirksen E. Bussiere et al. Nature Chemical Biology
- Efficient proximity labeling in living cells and organisms with TurboID
- (2018) Tess C Branon et al. NATURE BIOTECHNOLOGY
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
- (2018) Quinlan L. Sievers et al. SCIENCE
- Selective degradation of splicing factor CAPERα by anticancer sulfonamides
- (2017) Taisuke Uehara et al. Nature Chemical Biology
- Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- (2017) Robin M Meyers et al. NATURE GENETICS
- Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
- (2017) Ting Han et al. SCIENCE
- Small-Molecule PROTACS: New Approaches to Protein Degradation
- (2016) Momar Toure et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
- (2016) Tinghu Zhang et al. Nature Chemical Biology
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Catalytic in vivo protein knockdown by small-molecule PROTACs
- (2015) Daniel P Bondeson et al. Nature Chemical Biology
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
- (2014) Eric S. Fischer et al. NATURE
- Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN
- (2013) Anita K. Gandhi et al. BRITISH JOURNAL OF HAEMATOLOGY
- Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
- (2013) J. Kronke et al. SCIENCE
- The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
- (2013) G. Lu et al. SCIENCE
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
- (2012) Georg E Winter et al. Nature Chemical Biology
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- BamTools: a C++ API and toolkit for analyzing and managing BAM files
- (2011) D. W. Barnett et al. BIOINFORMATICS
- MultiBac: expanding the research toolbox for multiprotein complexes
- (2011) Christoph Bieniossek et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- Identification of a Primary Target of Thalidomide Teratogenicity
- (2010) T. Ito et al. SCIENCE
- E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification
- (2009) Danny T. Huang et al. MOLECULAR CELL
- A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery
- (2009) Ti Li et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies
- (2008) Wassim Abdulrahman et al. ANALYTICAL BIOCHEMISTRY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started