Article
Immunology
Asmaa M. Mohamed, Dina A. Ali, Eman Kolieb, Eman Z. Abdelaziz
Summary: Epilepsy is a serious neurological disorder that causes cognitive-psychosocial damage through recurrent seizures. Drug resistance is common among patients, so new drugs are needed to improve seizure management and quality of life. This study investigated the therapeutic effects of ceftriaxone and selenium against epilepsy in rats. The results showed that the combined treatment of selenium and ceftriaxone improved epilepsy symptoms by reducing oxidative stress and inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meiwen Guo, Shuang Chen, Jitong Lao, Jiantang Liang, Hao Chen, Jingyi Tong, Yonghao Huang, Dandan Jia, Qifu Li
Summary: This study investigated the effects of 3BDO on autophagy regulation and its impact on seizures and cognitive function in a PTZ-kindled epileptic mice model. The results showed that 3BDO can regulate autophagy by activating the mTOR signaling pathway, thereby reducing hippocampal neuronal loss and astrocyte proliferation, decreasing seizures, and significantly improving cognitive function.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jian Zhang, Keman Mu, Peng Yang, Xinqian Feng, Di Zhang, Xiangyu Fan, Qiantao Wang, Shengjun Mao
Summary: The study found that electron-donating methoxy groups on the 3,4,5 position of the phenyl ring enhanced the antiepileptic effects, while other groups at different positions decreased activity. Additionally, either an allyl or a 1-butenyl group in conjunction with the benzene ring showed optimal activity in the allyl moiety. Compounds 5 and 19 exhibited better neuroprotective effects against epilepsy in both in vitro and in vivo models.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Saeed Emami, Mehdi Valipour, Fatemeh Kazemi Komishani, Fatemehsadat Sadati-Ashrafi, Maria Rasoulian, Majid Ghasemian, Mahmood Tajbakhsh, Patrick Honarchian Masihi, Aidin Shakiba, Hamid Irannejad, Nematollah Ahangar
Summary: A series of new isatin aroylhydrazones were synthesized and evaluated for their anticonvulsant activities, with N-methyl analogs showing the strongest efficacy at a lower dose. Experimental determination of protein binding and lipophilicity was performed, while in silico evaluations showed acceptable ADME parameters and drug-likeness properties. Distance mapping and docking suggested possible actions on VGSCs and GABAA receptors, and cytotoxicity evaluation indicated safety profiles on neuronal and hepatic cells for selected compounds.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zsolt Gall, Krisztina Kelemen, Andrea Tolokan, Istvan Zolcseak, Istvan Savel, Reka Bod, Elek Ferencz, Szende Vancea, Melinda Urkon, Melinda Kolcsar
Summary: This study examines the effects of long-term CBD treatment in the PTZ-kindling model of epilepsy. The results show that CBD treatment decreases mortality rate and prolongs seizure latency, but also leads to cognitive impairment.
Article
Biochemistry & Molecular Biology
Libor Uttl, Tomas Hlozek, Pavel Mares, Tomas Palenicek, Hana Kubova
Summary: This study investigated the anti-seizure activity of CBD in infantile rats with chemically induced seizures, showing that CBD is effective against PTZ-induced seizures but not against NMDA-induced seizures. The levels of CBD in the brain and plasma were determined after administration, and it was found that therapeutic doses of CBD do not cause motor impairment but may affect motor performance in repeated tasks. Further research is needed to explore the potential risk of CBD on motor learning in repeated motor tests.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Patrick C. Milder, Agnes S. Zybura, Theodore R. Cummins, James A. Marrs
Summary: Approximately 30% of patients with epilepsy do not achieve adequate seizure control with current drugs and treatments, highlighting the need for more efficient screening methods. This study presents an optimized method using a zebrafish seizure model to screen anti-seizure drugs, comparing behavior and neural activity. The results show that EEG and GCaMP measurements largely correlate with behavior, providing a more comprehensive assessment of drug efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhenqi Yang, Yong Zou, Lifeng Wang
Summary: Alzheimer's disease is the most common cause of cognitive impairment in middle-aged and older populations. Understanding the impact of neurotransmitters in the progression and pathogenesis of AD is crucial, as synaptic plasticity plays a significant role in learning and memory. Research has shown the importance of neurotransmitters and their receptors in regulating synaptic plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Gabriele Ruffolo, Veronica Alfano, Alessia Romagnolo, Till Zimmer, James D. Mills, Pierangelo Cifelli, Alessandro Gaeta, Alessandra Morano, Jasper Anink, Angelika Muhlebner, Annamaria Vezzani, Eleonora Aronica, Eleonora Palma
Summary: This study found that the key anti-inflammatory cytokine IL-10 can significantly enhance GABAergic neurotransmission in Gangliogliomas (GGs) brain tumors, while the pro-inflammatory cytokine IL-1 beta reduces GABA current amplitude. These results suggest that in epileptogenic tissue, pro-inflammatory mechanisms of hyperexcitability prevail over key anti-inflammatory pathways.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Teresa Schmidt, Sebastian Meller, Steven R. Talbot, Benjamin A. Berk, Tsz H. Law, Sarah L. Hobbs, Nina Meyerhoff, Rowena M. A. Packer, Holger A. Volk
Summary: This study found significant differences in urinary neurotransmitter levels between dogs with epilepsy and healthy controls, suggesting that urinary neurotransmitters could serve as valuable biomarkers for diagnostics and treatment monitoring in canine epilepsy.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Seong Soon Kim, Hyemin Kan, Kyu-Seok Hwang, Jung Yoon Yang, Yuji Son, Dae-Seop Shin, Byung Hoi Lee, Se Hwan Ahn, Jin Hee Ahn, Sung-Hee Cho, Myung Ae Bae
Summary: GM-90432 improved PTZ-induced epileptic behaviors by modulating levels of neurotransmitters and hormones, and exerted protective effects against oxidative stress and zebrafish death. The study suggests that GM-90432 exhibits biphasic neuroprotective effects and may serve as a potential candidate for anti-epileptic drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mobin A. Siddiqui, Juheb Akhter, Dar Junaid Bashir, Saliha Manzoor, Shweta Rastogi, Indu Arora, Nidhi B. Aggarwal, Mohammed Samim
Summary: By encapsulating resveratrol in glutathione-coated collagen nanoparticles, the bioavailability of resveratrol is increased and it is successfully applied in the treatment of epilepsy, showing a significant impact in reducing cognitive impairment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Wanyu Liu, Jingqing Xu, Linhai Zhang, Fangjing Li, Lijia Zhang, Zhenzhen Tai, Juan Yang, Haiqing Zhang, Jinmei Tuo, Changyin Yu, Zucai Xu
Summary: Research has shown a correlation between human trace element levels and disease alterations, and epilepsy has been found to be closely related to abnormal levels of trace elements. Recent studies have focused on the role of metal ions such as selenium, iron, copper, zinc, and manganese in epileptic seizures. Treatment with drugs and a ketogenic diet also affects the concentration of trace elements in the serum of epilepsy patients, suggesting the significance of trace element imbalance in the occurrence and development of epilepsy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Geriatrics & Gerontology
Yilin Wang, Penghu Wei, Feng Yan, Yumin Luo, Guoguang Zhao
Summary: Epilepsy is a serious neurological disorder that can cause brain damage, and animal models help understand the mechanisms of epilepsy and select treatment drugs.
Article
Biochemistry & Molecular Biology
Adrian Bartoszek, Alicja Trzpil, Anna Kozub, Emilia Fornal
Summary: This study aimed to optimize the zebrafish larvae pentylenetetrazol-induced seizure model to investigate the interaction between caffeine and topiramate. An analytical method was developed to measure the levels of caffeine, topiramate, and its metabolite paraxanthine in zebrafish larvae. The results showed that caffeine and topiramate separately reduced the locomotor activity of zebrafish larvae but could not lower it to the control level. Co-administration of caffeine and topiramate at specific doses suppressed the activity to the control level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Christina Herold, Christina Paulitschek, Nicola Palomero-Gallagher, Onur Guentuerkuen, Karl Zilles
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Article
Neurosciences
Franziska Wedekind, Angela Oskamp, Markus Lang, Alexander Hawlitschka, Karl Zilles, Andreas Wree, Andreas Bauer
JOURNAL OF NEUROSCIENCE RESEARCH
(2018)
Article
Medicine, Research & Experimental
Juan Carlos Baldermann, Katja Hardenacke, Xiaochen Hu, Phillip Koester, Andreas Horn, Hans-Joachim Freund, Karl Zilles, Volker Sturm, Veerle Visser-Vandewalle, Frank Jessen, David Maintz, Jens Kuhn
Article
Neurosciences
Christina Herold, Hans-Juergen Bidmon, Heinz W. Pannek, Volkmar Hans, Ali Gorji, Erwin-Josef Speckmann, Karl Zilles
Article
Neurosciences
T. Mann, K. Zilles, H. Dikow, A. Hellfritsch, M. Cremer, M. Piel, F. Roesch, A. Hawlitschka, O. Schmitt, A. Wree
Review
Neurosciences
Alexandros Goulas, Karl Zilles, Claus C. Hilgetag
TRENDS IN NEUROSCIENCES
(2018)
Article
Food Science & Technology
Veronica Antipova, Andreas Wree, Carsten Holzmann, Teresa Mann, Nicola Palomero-Gallagher, Karl Zilles, Oliver Schmitt, Alexander Hawlitschka
Article
Anatomy & Morphology
Teresa Mann, Karl Zilles, Felix Klawitter, Markus Cremer, Alexander Hawlitschka, Nicola Palomero-Gallagher, Oliver Schmitt, Andreas Wree
FRONTIERS IN NEUROANATOMY
(2018)
Editorial Material
Clinical Neurology
Karl Zilles
Article
Neurosciences
Monika Richter, Katrin Amunts, Hartmut Mohlberg, Sebastian Bludau, Simon B. Eickhoff, Karl Zilles, Svenja Caspers
Editorial Material
Neurosciences
Arleen Salles, Jan G. Bjaalie, Kathinka Evers, Michele Farisco, B. Tyr Fothergill, Manuel Guerrero, Hannah Maslen, Jeffrey Muller, Tony Prescott, Bernd C. Stahl, Henrik Walter, Karl Zilles, Katrin Amunts
Article
Multidisciplinary Sciences
Nora Bittner, Christiane Jockwitz, Thomas W. Muehleisen, Felix Hoffstaedter, Simon B. Eickhoff, Susanne Moebus, Ute J. Bayen, Sven Cichon, Karl Zilles, Katrin Amunts, Svenja Caspers
NATURE COMMUNICATIONS
(2019)
Meeting Abstract
Clinical Neurology
Christian J. Hartmann, Peter Pieperhoff, Holger Krause, Stefano Ferrea, Alexia S. Moldovan, Lars Wojtecki, Karl Zilles, Katrin Amunts, Alfons Schnitzler, Martin Suedmeyer
JOURNAL OF NEURAL TRANSMISSION
(2019)
Article
Anatomy & Morphology
Olga Kedo, Karl Zilles, Nicola Palomero-Gallagher, Axel Schleicher, Hartmut Mohlberg, Sebastian Bludau, Katrin Amunts
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.