Pathophysiology of Hypertension

Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk

(2021) Felix Vaura et al.   HYPERTENSION

Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance

(2020) Leon J. DeLalio et al.   CANADIAN JOURNAL OF CARDIOLOGY

Sympathetic Enhancement of Memory T Cell Homing and Hypertension Sensitization

(2020) Liang Xiao et al.   CIRCULATION RESEARCH

The Unrecognized Prevalence of Primary Aldosteronism

(2020) Jenifer M. Brown et al.   ANNALS OF INTERNAL MEDICINE

Genomics of Blood Pressure and Hypertension: Extending the Mosaic Theory Toward Stratification

(2020) Stefanie Lip et al.   CANADIAN JOURNAL OF CARDIOLOGY

Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects

(2020) Matthew Griffin et al.   CIRCULATION

Antihypertensive and Renal Mechanisms of SGLT2 (Sodium-Glucose Linked Transporter 2) Inhibitors

(2020) Christopher S. Wilcox   HYPERTENSION

Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease

(2020) Maria V. Irazabal et al.   Cells

Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction

(2020) Wei Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Christopher J L Murray et al.   LANCET

Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway

(2020) Isaivani Jayachandran et al.   Scientific Reports

Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct

(2020) Andrew C. Curnow et al.   Frontiers in Physiology

Deciphering the Identity of Renin Cells in Health and Disease

(2020) Omar Guessoum et al.   TRENDS IN MOLECULAR MEDICINE

Central Inhibition of Tumor Necrosis Factor Alpha Reduces Hypertension by Attenuating Oxidative Stress in the Rostral Ventrolateral Medulla in Renovascular Hypertensive Rats

(2019) Alynne Carvalho-Galvão et al.   Frontiers in Physiology

High Salt Activates CD11c + Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension

(2019) Justin P. Van Beusecum et al.   HYPERTENSION

Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes

(2019) Ramachandran S. Vasan et al.   Journal of the American Heart Association

Adipocytes initiate an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high-fat feeding

(2019) Wei Cao et al.   CLINICAL SCIENCE

Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated

(2019) Claudia P Cabrera et al.   HUMAN MOLECULAR GENETICS

Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling

(2019) Calum Wilson et al.   HYPERTENSION

Aliskiren and the dual complement inhibition concept

(2019) Maria Vanessa Perez-Gomez et al.   Clinical Kidney Journal

Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation

(2019) Liang Xiao et al.   HYPERTENSION

Salt, inflammation, IL-17 and hypertension

(2018) Ulrich O Wenzel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

(2018) Roxana Loperena et al.   CARDIOVASCULAR RESEARCH

Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5

(2018) Caroline Arnold et al.   FASEB JOURNAL

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

(2018) Paul K. Whelton et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aliskiren inhibits renin-mediated complement activation

(2018) Zivile D. Békássy et al.   KIDNEY INTERNATIONAL

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II–mediated blood pressure control

(2018) Jyoti Patel et al.   VASCULAR PHARMACOLOGY

Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning

(2018) Ryan Poplin et al.   Nature Biomedical Engineering

Dietary metabolism, the gut microbiome, and heart failure

(2018) W. H. Wilson Tang et al.   Nature Reviews Cardiology

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation

(2017) Kento Kitada et al.   JOURNAL OF CLINICAL INVESTIGATION

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

Beyond gut feelings: how the gut microbiota regulates blood pressure

(2017) Francine Z. Marques et al.   Nature Reviews Cardiology

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

(2017) Sabine Kossmann et al.   Science Translational Medicine

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension

(2017) Natalia R. Barbaro et al.   Cell Reports

Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

(2017) Michal Behuliak et al.   Biomed Research International

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced HypertensionResponse to Morris et al

(2016) R. Curtis Morris et al.   CIRCULATION

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Global Disparities of Hypertension Prevalence and ControlClinical Perspective

(2016) Katherine T. Mills et al.   CIRCULATION

Central Artery Stiffness in Hypertension and Aging

(2016) Jay D. Humphrey et al.   CIRCULATION RESEARCH

Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in FemalesNovelty and Significance

(2016) Guanghong Jia et al.   CIRCULATION RESEARCH

RhoA/Rho-Kinase in the Cardiovascular System

(2016) Hiroaki Shimokawa et al.   CIRCULATION RESEARCH

Hypertension-Linked Pathophysiological Alterations in the GutNovelty and Significance

(2016) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension

(2016) Tomasz P. Mikolajczyk et al.   FASEB JOURNAL

Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive SubjectsNovelty and Significance

(2016) Cheryl L. Laffer et al.   HYPERTENSION

Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated HypertensionNovelty and Significance

(2016) Alfredo Gamboa et al.   HYPERTENSION

Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood PressureNovelty and Significance

(2016) Brian J. Kinsman et al.   HYPERTENSION

Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II–Induced HypertensionNovelty and Significance

(2016) Allison E. Norlander et al.   HYPERTENSION

Resting Afferent Renal Nerve Discharge and Renal InflammationNovelty and Significance

(2016) Christopher T. Banek et al.   HYPERTENSION

Salt Sensitivity of Blood Pressure

(2016) Fernando Elijovich et al.   HYPERTENSION

Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II – induced hypothalamic reactive oxygen species and hypertension

(2016) Hong-Wei Wang et al.   NEUROSCIENCE

Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure

(2016) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense

(2015) Jonathan Jantsch et al.   Cell Metabolism

Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II–Induced HypertensionNovelty and Significance

(2015) Liang Xiao et al.   CIRCULATION RESEARCH

Maintaining Balance Under Pressure: Figure.

(2015) Alicia A. McDonough et al.   HYPERTENSION

Remodeling of Afferent Arterioles From Mice With Oxidative Stress Does Not Account for Increased Contractility but Does Limit Excessive Wall StressNovelty and Significance

(2015) Lingli Li et al.   HYPERTENSION

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Immune activation caused by vascular oxidation promotes fibrosis and hypertension

(2015) Jing Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tobacco smoking strengthens the association of elevated blood pressure with arterial stiffness

(2015) Miaoying Yun et al.   JOURNAL OF HYPERTENSION

Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension

(2015) Qiang Li et al.   JOURNAL OF HYPERTENSION

A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression

(2015) W. Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evidence for a link between gut microbiota and hypertension in the Dahl rat

(2015) Blair Mell et al.   PHYSIOLOGICAL GENOMICS

Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction

(2014) Adam C. Straub et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel and Nonpharmacologic Approaches to Cardio-Protection in Hypertension

(2014) Luca Donazzan et al.   CURRENT HYPERTENSION REPORTS

Oligoclonal CD8 + T Cells Play a Critical Role in the Development of Hypertension

(2014) Daniel W. Trott et al.   HYPERTENSION

DC isoketal-modified proteins activate T cells and promote hypertension

(2014) Annet Kirabo et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Role of Glucose Metabolism, Osmotic Stress, and Sodium-Glucose Cotransporter Isoform-Mediated Transport on Na+/H+ Exchanger Isoform 3 Activity in the Renal Proximal Tubule

(2014) T. D. Pessoa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mineralocorticoid receptors in immune cells: Emerging role in cardiovascular disease

(2014) Nicholas C. Bene et al.   STEROIDS

Oxidative Stress in Hypertension: Role of the Kidney

(2013) Magali Araujo et al.   ANTIOXIDANTS & REDOX SIGNALING

Central hemodynamic modifications in diabetes mellitus

(2013) Davide Agnoletti et al.   ATHEROSCLEROSIS

Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase

(2013) Jing Wu et al.   CIRCULATION RESEARCH

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

(2013) Robert M. Weisbrod et al.   HYPERTENSION

23 Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients

(2013) Christoph Kopp et al.   HYPERTENSION

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

The Mosaic Theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension

(2013) David G. Harrison   Journal of the American Society of Hypertension

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials

(2013) F. J. He et al.   BMJ-British Medical Journal

Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension

(2012) Hoanglan Nguyen et al.   CARDIOVASCULAR RESEARCH

Neurohormonal Modulation of the Innate Immune System Is Proinflammatory in the Prehypertensive Spontaneously Hypertensive Rat, a Genetic Model of Essential Hypertension

(2012) Sailesh C. Harwani et al.   CIRCULATION RESEARCH

Asymmetric Dimethylarginine and Reactive Oxygen Species

(2012) Christopher S. Wilcox   HYPERTENSION

Role of the NADPH Oxidases in the Subfornical Organ in Angiotensin II–Induced Hypertension

(2012) Heinrich E. Lob et al.   HYPERTENSION

Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

(2012) Adam C. Straub et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Remodeling of Retinal Small Arteries in Hypertension

(2011) M. V. Lehmann et al.   AMERICAN JOURNAL OF HYPERTENSION

Natural Regulatory T Cells Control Coronary Arteriolar Endothelial Dysfunction in Hypertensive Mice

(2011) Khalid Matrougui et al.   AMERICAN JOURNAL OF PATHOLOGY

Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

(2011) Scott C. Thomson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Interleukin-10 Released by CD4 + CD25 + Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice

(2011) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Salt Sensitivity in Blacks

(2011) Olga Schmidlin et al.   HYPERTENSION

23 Na Magnetic Resonance Imaging of Tissue Sodium

(2011) Christoph Kopp et al.   HYPERTENSION

Albumin overload activates intrarenal renin–angiotensin system through protein kinase C and NADPH oxidase-dependent pathway

(2011) Wei Cao et al.   JOURNAL OF HYPERTENSION

Compartmentalized Connexin 43 S -Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall

(2010) Adam C. Straub et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II–Induced Hypertension

(2010) Paul J. Marvar et al.   CIRCULATION RESEARCH

Renal Actions of RGS2 Control Blood Pressure

(2010) S. B. Gurley et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Physiology of Kidney Renin

(2010) Hayo Castrop et al.   PHYSIOLOGICAL REVIEWS

Renal Proximal Tubular Reabsorption Is Reduced In Adult Spontaneously Hypertensive Rats

(2009) Carolina Panico et al.   HYPERTENSION

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Induction of Hypertension and Peripheral Inflammation by Reduction of Extracellular Superoxide Dismutase in the Central Nervous System

(2009) Heinrich E. Lob et al.   HYPERTENSION

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

A comprehensive review on salt and health and current experience of worldwide salt reduction programmes

(2008) F J He et al.   JOURNAL OF HUMAN HYPERTENSION

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

(2008) J. Ledoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA