Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

Cardiosphere-Derived Cells and Ischemic Heart Failure

(2018) Carmel Ashur et al.   Cardiology in Review

The Secret Life of Exosomes

(2018) Eduardo Marbán   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exosome-Mediated Benefits of Cell Therapy in Mouse and Human Models of Duchenne Muscular Dystrophy

(2018) Mark A. Aminzadeh et al.   Stem Cell Reports

A mechanistic roadmap for the clinical application of cardiac cell therapies

(2018) Eduardo Marbán   Nature Biomedical Engineering

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

(2018) Bohao Liu et al.   Nature Biomedical Engineering

Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation

(2018) Yidong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability

(2017) Emma Harvey et al.   Stem Cells Translational Medicine

Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology

(2016) Ahmed Ibrahim et al.   Annual Review of Physiology

Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid

(2016) Johnny C. Akers et al.   Cancer Biomarkers

miR-709 modulates LPS-induced inflammatory response through targeting GSK-3β

(2016) Ming Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

GSK-3β Inhibitor CHIR-99021 Promotes Proliferation Through Upregulating β-Catenin in Neonatal Atrial Human Cardiomyocytes

(2016) Shoubao Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea

(2016) Wenli Ni et al.   JOURNAL OF NEUROSCIENCE

Epithelial to mesenchymal transition-related proteins ZEB1, β-catenin and β-tubulin-III in idiopathic pulmonary fibrosis

(2016) Marco Chilosi et al.   MODERN PATHOLOGY

Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling

(2016) Peter Hofsteen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/β-catenin signaling

(2016) Yung-Chien Hsu et al.   Scientific Reports

The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics

(2016) Diego A. Vargas et al.   PLoS Computational Biology

Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome

(2016) Brittany A. Potz et al.   Journal of the American Heart Association

Challenges in the translation and commercialization of cell therapies

(2015) Brittany P. Dodson et al.   BMC BIOTECHNOLOGY

A novel regulatory function for miR-29a in keloid fibrogenesis

(2015) G.-Y. Zhang et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Quantitative activation suppression assay to evaluate human bone marrow–derived mesenchymal stromal cell potency

(2015) Bahey Salem et al.   CYTOTHERAPY

Inhibition of  -catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes

(2015) N. J. Palpant et al.   DEVELOPMENT

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling

(2015) Graeme M. Birdsey et al.   DEVELOPMENTAL CELL

The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development

(2015)   MOLECULES AND CELLS

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

(2015) J Cosín-Roger et al.   Mucosal Immunology

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

The Importance of the Canonical Wnt Signaling Pathway in the Porcine Endometrial Stromal Stem/Progenitor Cells: Implications for Regeneration

(2015) Joanna Bukowska et al.   STEM CELLS AND DEVELOPMENT

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3

(2014) L. Cambier et al.   DEVELOPMENT

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair

(2014) Ke Cheng et al.   JACC-Heart Failure

MicroRNA-92a Upholds Bmp Signaling by Targeting noggin3 during Pharyngeal Cartilage Formation

(2013) Guozhu Ning et al.   DEVELOPMENTAL CELL

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD

(2013) D Ortiz-Masiá et al.   Mucosal Immunology

Role of miR-17 Family in the Negative Feedback Loop of Bone Morphogenetic Protein Signaling in Neuron

(2013) Qi Sun et al.   PLoS One

Wnt/ -catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells

(2012) A. Klaus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin

(2011) Jing Li et al.   CLINICAL SCIENCE

Deletion of Glycogen Synthase Kinase-3β in Cartilage Results in Up-Regulation of Glycogen Synthase Kinase-3α Protein Expression

(2011) J. R. Gillespie et al.   ENDOCRINOLOGY

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

(2011) Tian Chen et al.   Journal of Translational Medicine

Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival

(2010) Hongxia Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

(2010) Isotta Chimenti et al.   CIRCULATION RESEARCH

Human cardiac mesoangioblasts isolated from hypertrophic cardiomyopathies are greatly reduced in proliferation and differentiation potency

(2009) B. G. Galvez et al.   CARDIOVASCULAR RESEARCH

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL