Endocrine disrupting chemicals and metabolic disorders in the liver: What if we also looked at the female side?

Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals

(2020) Riann Jenay Egusquiza et al.   ENDOCRINOLOGY

Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin

(2020) Tiffany A. Katz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

(2020) Michael Thoene et al.   Nutrients

Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis in CD-1 mice

(2020) Dan Feng et al.   ENVIRONMENTAL POLLUTION

The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds

(2020) Juliette Legler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Environmental estrogen exposure converts lipid metabolism in male fish to a female pattern mediated by AMPK and mTOR signaling pathways

(2020) Sheng-Xiang Sun et al.   JOURNAL OF HAZARDOUS MATERIALS

Endocrine-disrupting chemicals: economic, regulatory, and policy implications

(2020) Christopher D Kassotis et al.   Lancet Diabetes & Endocrinology

Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies

(2020) Safi U. Khan et al.   JAMA Network Open

Gender and sex disparity in cancer trials

(2020) Eudocia Lee et al.   ESMO Open

Exposure to pollutants altered glucocorticoid signaling and clock gene expression in female mice. Evidence of tissue- and sex-specificity

(2020) Nathalie Vega et al.   CHEMOSPHERE

Sex differences in the gut microbiota as potential determinants of gender predisposition to disease

(2019) Jose A. Santos-Marcos et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

(2019) Kelly A. Fader et al.   Scientific Reports

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

(2019) Benjamin D. Weger et al.   BIOESSAYS

Microbiota and nonalcoholic fatty liver disease

(2019) Christelle Knudsen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives

(2019) Hélène Serra et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Developmental exposure to the endocrine disruptor tolylfluanid induces sex-specific later-life metabolic dysfunction

(2019) Daniel Ruiz et al.   REPRODUCTIVE TOXICOLOGY

A curated knowledgebase on endocrine disrupting chemicals and their biological systems-level perturbations

(2019) Bagavathy Shanmugam Karthikeyan et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Prenatal low-dose DEHP exposure induces metabolic adaptation and obesity: Role of hepatic thiamine metabolism

(2019) Yun Fan et al.   JOURNAL OF HAZARDOUS MATERIALS

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

(2019) Céline Lukowicz et al.   Scientific Reports

Hepatic ERα accounts for sex differences in the ability to cope with an excess of dietary lipids

(2019) Clara Meda et al.   Molecular Metabolism

New insight into the mechanism of POP-induced obesity: Evidence from DDE-altered microbiota

(2019) Yiran Liang et al.   CHEMOSPHERE

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

(2018) Jukka Hakkola et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver

(2018) Sara Della Torre et al.   Cell Metabolism

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

(2018) Céline Lukowicz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evidence for estrogeno-mimetic effects of a mixture of low-dose pollutants in a model of ovariectomized mice

(2018) Benoit Julien et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells

(2018) Dounia Le Guillou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Extranuclear-initiated estrogenic actions of endocrine disrupting chemicals: Is there toxicology beyond paracelsus?

(2018) Angel Nadal et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulatory identification of BPA as an endocrine disruptor: Context and methodology

(2018) C. Beausoleil et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of bisphenol A on metabolism and evidences of a mode of action mediated through endocrine disruption

(2018) Brigitte Le Magueresse-Battistoni et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genomics of sex hormone receptor signaling in hepatic sexual dimorphism

(2018) Daoshan Zheng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo

(2018) Simon Bucher et al.   Scientific Reports

Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance

(2018) Hannah E. Da Silva et al.   Scientific Reports

Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice

(2018) Matthew A. Quinn et al.   Cell Reports

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

The OECD framework for AOP Development and the supporting tools

(2018) A. Gourmelon   TOXICOLOGY LETTERS

The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

(2018) Benjamin D. Weger et al.   Cell Metabolism

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression

(2018) Doris Kaltenecker et al.   CYTOKINE

Reproductive Endocrinology of Non-Alcoholic Fatty Liver Disease

(2018) Mathis Grossmann et al.   ENDOCRINE REVIEWS

Sex-related factors in autoimmune liver diseases

(2018) Dorothee Schwinge et al.   Seminars in Immunopathology

Environmental Pollutants and Metabolic Disorders: The Multi-Exposure Scenario of Life

(2018) Brigitte Le Magueresse-Battistoni et al.   Frontiers in Endocrinology

Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease

(2018) Yulang Chi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Phthalates impact human health: Epidemiological evidences and plausible mechanism of action

(2017) Sailas Benjamin et al.   JOURNAL OF HAZARDOUS MATERIALS

Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet

(2017) Emmanuel Labaronne et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Food additives, contaminants and other minor components: effects on human gut microbiota—a review

(2017) Paula Roca-Saavedra et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States

(2017) Dana Lau-Corona et al.   MOLECULAR AND CELLULAR BIOLOGY

Endocrine-disrupting chemicals and the regulation of energy balance

(2017) Angel Nadal et al.   Nature Reviews Endocrinology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

(2017) Rance Nault et al.   PLoS One

Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression

(2017) Ysabel Ilagan et al.   REPRODUCTIVE TOXICOLOGY

Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males

(2017) Shuiqing Qiu et al.   Scientific Reports

Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development

(2017) Yann Malaisé et al.   Scientific Reports

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

(2017) Kelly A. Fader et al.   Scientific Reports

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model

(2016) Caroline Duval et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression

(2016) Matthew A. Quinn et al.   FASEB JOURNAL

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

(2016) M. Schwarzer et al.   SCIENCE

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle

(2016) Sara Della Torre et al.   Cell Reports

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

(2016) Petr Pavek   Frontiers in Pharmacology

Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event

(2016) Keiyu Oshida et al.   PLoS One

The history of Distilbène® (Diethylstilbestrol) told to grandchildren – the transgenerational effect

(2015) Patrick Fénichel et al.   ANNALES D ENDOCRINOLOGIE

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

(2015) A. C. Gore et al.   ENDOCRINE REVIEWS

Dietary Exposure to the Endocrine Disruptor Tolylfluanid Promotes Global Metabolic Dysfunction in Male Mice

(2015) Shane M. Regnier et al.   ENDOCRINOLOGY

Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure

(2015) C-X Xu et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice

(2015) T. Y. Xie et al.   JOURNAL OF NEUROENDOCRINOLOGY

Growth Hormone Dynamics in Healthy Adults Are Related to Age and Sex and Strongly Dependent on Body Mass Index

(2015) Ferdinand Roelfsema et al.   NEUROENDOCRINOLOGY

Metabolic Outcome of Female Mice Exposed to a Mixture of Low-Dose Pollutants in a Diet-Induced Obesity Model

(2015) Danielle Naville et al.   PLoS One

Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

(2015) Rita S. Strakovsky et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Compound- and sex-specific effects on programming of energy and immune homeostasis in adult C57BL/6JxFVB mice after perinatal TCDD and PCB 153

(2015) J.C.J. van Esterik et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

(2015) Vanessa Delfosse et al.   Nature Communications

Sex differences in metabolic homeostasis, diabetes, and obesity

(2015) Franck Mauvais-Jarvis   Biology of Sex Differences

A structural perspective on nuclear receptors as targets of environmental compounds

(2014) Vanessa Delfosse et al.   ACTA PHARMACOLOGICA SINICA

Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment

(2014) Andreas Kortenkamp   CURRENT OPINION IN PHARMACOLOGY

The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine production in human adipocytes

(2014) M-J Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepatic Overexpression of Steroid Sulfatase Ameliorates Mouse Models of Obesity and Type 2 Diabetes through Sex-specific Mechanisms

(2014) Mengxi Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifelong consumption of low-dosed food pollutants and metabolic health

(2014) Brigitte Le Magueresse-Battistoni et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Estrogen biology: New insights into GPER function and clinical opportunities

(2014) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice

(2014) Sébastien Anthérieu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

State of the Science of Endocrine Disruptors

(2013) Linda S. Birnbaum   ENVIRONMENTAL HEALTH PERSPECTIVES

Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice

(2013) Danielle Naville et al.   FASEB JOURNAL

Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice

(2013) Kazunari Nohara et al.   JOURNAL OF ENDOCRINOLOGY

Influence of Patient Sex and Gender on Medication Use, Adherence, and Prescribing Alignment with Guidelines

(2013) Marie Manteuffel et al.   JOURNAL OF WOMENS HEALTH

Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver

(2013) A. Sugathan et al.   MOLECULAR AND CELLULAR BIOLOGY

The Endocrine Disrupting Chemical Tolylfluanid Alters Adipocyte Metabolism via Glucocorticoid Receptor Activation

(2013) Brian A. Neel et al.   MOLECULAR ENDOCRINOLOGY

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Estrogen Signalling and the Metabolic Syndrome: Targeting the Hepatic Estrogen Receptor Alpha Action

(2013) Marko Matic et al.   PLoS One

Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology

(2013) Laura N. Vandenberg et al.   REPRODUCTIVE TOXICOLOGY

Adrenal tumours are more predominant in females regardless of their histological subtype: a review

(2013) François Audenet et al.   WORLD JOURNAL OF UROLOGY

Estrogens Regulate the Hepatic Effects of Growth Hormone, a Hormonal Interplay with Multiple Fates

(2013) Leandro Fernández-Pérez et al.   Frontiers in Endocrinology

Public health concern behind the exposure to persistent organic pollutants and the risk of metabolic diseases

(2012) Jérôme Ruzzin   BMC PUBLIC HEALTH

Sex-Specific Effect of Estrogen Sulfotransferase on Mouse Models of Type 2 Diabetes

(2012) J. Gao et al.   DIABETES

Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society

(2012) R. Thomas Zoeller et al.   ENDOCRINOLOGY

Developmental origins of non-communicable disease: Implications for research and public health

(2012) Robert Barouki et al.   Environmental Health

Effects of Di(2-ethylhexyl) Phthalate (DEHP) on Female Fertility and Adipogenesis in C3H/N Mice

(2012) Juliane-Susanne Schmidt et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Role of Environmental Chemicals in Diabetes and Obesity: A National Toxicology Program Workshop Review

(2012) Kristina A. Thayer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants

(2012) Michele La Merrill et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat

(2012) Hua Zhang et al.   JOURNAL OF LIPID RESEARCH

Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development

(2012) Kristina M. Mueller et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endocrine Disruptors: From Endocrine to Metabolic Disruption

(2011) Cristina Casals-Casas et al.   Annual Review of Physiology

Sex differences in nuclear receptor-regulated liver metabolic pathways

(2011) Gianpaolo Rando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism

(2011) Guoping Li et al.   JOURNAL OF LIPID RESEARCH

Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice

(2011) Mark J. Hoenerhoff et al.   TOXICOLOGIC PATHOLOGY

Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity

(2010) Anna Ruggieri et al.   INTERNATIONAL JOURNAL OF CANCER

In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice

(2010) Francesca Maranghi et al.   REPRODUCTIVE TOXICOLOGY

Birth Defects in Wildlife: The Role of Environmental Contaminants as Inducers of Reproductive and Developmental Dysfunction

(2010) Heather J. Hamlin et al.   Systems Biology in Reproductive Medicine

Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity

(2010) Franck Mauvais-Jarvis   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic syndrome and hepatocellular carcinoma

(2009) Abby B. Siegel et al.   CANCER

Hormonal regulation of CYP1A expression

(2009) Katalin Monostory et al.   DRUG METABOLISM REVIEWS

Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption

(2009) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

(2009) Evanthia Diamanti-Kandarakis et al.   ENDOCRINE REVIEWS

Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice

(2009) Elodie Riant et al.   ENDOCRINOLOGY

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Environmental Endocrine Disruptors Promote Adipogenesis in the 3T3-L1 Cell Line through Glucocorticoid Receptor Activation

(2009) Robert M. Sargis et al.   Obesity

Human body burdens of chemicals used in plastic manufacture

(2009) H. M. Koch et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Metabolism, variability and risk assessment

(2009) J.L.C.M. Dorne   TOXICOLOGY

Expression Pattern of G Protein-Coupled Receptor 30 in LacZ Reporter Mice

(2008) Jörg Isensee et al.   ENDOCRINOLOGY

Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice

(2008) Ulrika E. A. Mårtensson et al.   ENDOCRINOLOGY

Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-Feeding

(2008) Meghan O’Grady Milbrath et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor

(2008) Hung-Yun Lin et al.   HEPATOLOGY

How growth hormone controls growth, obesity and sexual dimorphism

(2007) Agnieszka M. Lichanska et al.   TRENDS IN GENETICS