Using Rotenone to Model Parkinson’s Disease in Mice: A Review of the Role of Pharmacokinetics

Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism

(2020) James C. Fuscoe et al.   DRUG METABOLISM AND DISPOSITION

Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson’s Disease

(2020) Ikuko Miyazaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation

(2020) Gul Ozbey et al.   Pharmacological Reports

Protective effect of metformin against rotenone-induced parkinsonism in mice

(2020) Dong-Xin Wang et al.   TOXICOLOGY MECHANISMS AND METHODS

Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation

(2020) Qiong Cheng et al.   ACTA PHARMACOLOGICA SINICA

Effects of Enteric Environmental Modification by Coffee Components on Neurodegeneration in Rotenone-Treated Mice

(2019) Ikuko Miyazaki et al.   Cells

Separating host and microbiome contributions to drug pharmacokinetics and toxicity

(2019) Michael Zimmermann et al.   SCIENCE

Mechanistic comparison between MPTP and rotenone neurotoxicity in mice

(2019) Sunil Bhurtel et al.   NEUROTOXICOLOGY

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Predicting and Understanding the Human Microbiome’s Impact on Pharmacology

(2019) Reese Hitchings et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice

(2019) Akinyinka O. Alabi et al.   NEUROTOXICOLOGY

The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease

(2019) Mahesh Ramalingam et al.   Frontiers in Neuroscience

Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway

(2019) Li-Min Zhang et al.   Aging-US

Parkinson disease

(2019) R. Balestrino et al.   EUROPEAN JOURNAL OF NEUROLOGY

Involvement of Akt/mTOR in the Neurotoxicity of Rotenone-Induced Parkinson’s Disease Models

(2019) Yu Zhang et al.   International Journal of Environmental Research and Public Health

Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson’s disease mice model

(2019) Tarek K. Motawi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?

(2019) Abdullah Al Shoyaib et al.   PHARMACEUTICAL RESEARCH

Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

(2018) Jia Liu et al.   Autophagy

Bioavailability and Pharmacokinetics of Oral Cocaine in Humans

(2018) Marion A Coe et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson’s disease

(2018) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice

(2018) Giuseppe Tatulli et al.   Frontiers in Cellular Neuroscience

Longitudinal Analysis of Fecal Microbiome and Pathologic Processes in a Rotenone Induced Mice Model of Parkinson’s Disease

(2018) Xiaodong Yang et al.   Frontiers in Aging Neuroscience

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

(2018) A. K. J. Gradel et al.   Journal of Diabetes Research

The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson’s Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy

(2018) Bing Wang et al.   Frontiers in Molecular Neuroscience

Gut bacterial composition in a mouse model of Parkinson’s disease

(2018) P. Perez-Pardo et al.   Beneficial Microbes

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

(2018) Paula Perez-Pardo et al.   GUT

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

(2018) Hemraj B. Dodiya et al.   NEUROBIOLOGY OF DISEASE

Occupational pesticide use and Parkinson's disease in the Parkinson Environment Gene (PEG) study

(2017) Shilpa Narayan et al.   ENVIRONMENT INTERNATIONAL

Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study

(2017) Camille Pouchieu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

Parkinson’s disease-like motor and non-motor symptoms in rotenone-treated zebrafish

(2017) Yali Wang et al.   NEUROTOXICOLOGY

Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet

(2017) Paula Perez-Pardo et al.   NUTRITIONAL NEUROSCIENCE

Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice

(2017) Veerappan Venkatesh Gobi et al.   NUTRITIONAL NEUROSCIENCE

Editor’s Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice

(2017) Eileen M. Martinez et al.   TOXICOLOGICAL SCIENCES

Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease

(2017) Hui-Fang Liu et al.   Scientific Reports

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease

(2017) Paula Perez-Pardo et al.   Frontiers in Aging Neuroscience

S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation

(2017) Roshan Kumar et al.   Scientific Reports

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

(2016) Christopher R. Jones et al.   AAPS Journal

Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson’s Disease Cell and Animal Models

(2016) Hongxiang Sun et al.   ACS Chemical Neuroscience

Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease

(2016) Qi Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson’s disease

(2016) Mike Arnhold et al.   CLINICAL AUTONOMIC RESEARCH

Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

(2016) G. Martella et al.   NEUROBIOLOGY OF DISEASE

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Synthesis and neuroprotective effects of the complex nanoparticles of iron and sapogenin isolated from the defatted seeds of Camellia oleifera

(2016) Qian Yang et al.   PHARMACEUTICAL BIOLOGY

Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson's disease

(2016) Dharmendra K. Khatri et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson’s disease model

(2016) Jia Liu et al.   Oncotarget

Environment-contact administration of rotenone: A new rodent model of Parkinson’s disease

(2015) Yan Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson’s Disease in Mice

(2015) Shinki Murakami et al.   NEUROCHEMICAL RESEARCH

Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson’s disease

(2015) S. Mitra et al.   NEUROSCIENCE

Intranasal administration of rotenone in mice attenuated olfactory functions through the lesion of dopaminergic neurons in the olfactory bulb

(2015) Hitoshi Sasajima et al.   NEUROTOXICOLOGY

Oral Supplements of Aqueous Extract of Tomato Seeds Alleviate Motor Abnormality, Oxidative Impairments and Neurotoxicity Induced by Rotenone in Mice: Relevance to Parkinson’s Disease

(2014) Krishna Gokul et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effects of Metallothionein Against Rotenone-Induced Myenteric Neurodegeneration in Parkinsonian Mice

(2014) Shinki Murakami et al.   NEUROTOXICITY RESEARCH

Unexpected Improvements of Spatial Learning and Memory Abilities in Chronic Rotenone Intoxicated Mice

(2014) Fengju Jia et al.   PLoS One

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats

(2013) Pádraig Mulcahy et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective Effect of Aqueous Extract of Selaginella delicatula as Evidenced by Abrogation of Rotenone-Induced Motor Deficits, Oxidative Dysfunctions, and Neurotoxicity in Mice

(2013) Girish Chandran et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Effects of oral administration of rotenone on gastrointestinal functions in mice

(2013) M. Tasselli et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson’s disease

(2013) R. St. Laurent et al.   NEUROSCIENCE

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

Regenerative effects of umbilical cord matrix cells (UCMCs) in a rodent model of rotenone neurotoxicity

(2012) Mohamed Salama et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Protection by an antioxidant of rotenone-induced neuromotor decline, reactive oxygen species generation and cellular stress in mouse brain

(2012) Kodeeswaran Parameshwaran et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell Death

(2012) Samantha Giordano et al.   PLoS One

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice

(2011) Masatoshi Inden et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Parkinson’s disease among gardeners exposed to pesticides – a Danish cohort study

(2011) Line Kenborg et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Association between environmental exposure to pesticides and neurodegenerative diseases

(2011) Tesifón Parrón et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pesticidal suicide: Adult fatal rotenone poisoning

(2011) Freddy Patel   Journal of Forensic and Legal Medicine

Cytochrome P450-mediated metabolism in the human gut wall

(2010) Kirstin Thelen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five french districts

(2010) Frédéric Moisan et al.   MOVEMENT DISORDERS

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Professional exposure to pesticides and Parkinson disease

(2009) Alexis Elbaz et al.   ANNALS OF NEUROLOGY

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

(2009) James G. Greene et al.   EXPERIMENTAL NEUROLOGY

Solubility, stability, and synergistic acaricidal activity of rotenone in mandarin oil

(2009) Xin-Nian Zeng et al.   INTERNATIONAL JOURNAL OF ACAROLOGY

Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice

(2009) Masatoshi Inden et al.   NEUROCHEMISTRY INTERNATIONAL

Subcutaneous and Intraperitoneal Lipogranulomas Following Subcutaneous Injection of Olive Oil in Sprague-Dawley Rats

(2009) Yuval Ramot et al.   TOXICOLOGIC PATHOLOGY

Vascular Pathology in Male Lewis Rats following Short-Term, Low-Dose Rotenone Administration

(2009) A. L. Allen et al.   VETERINARY PATHOLOGY

Rotenone: An Essential but Demonized Tool for Assessing Marine Fish Diversity

(2008) D. Ross Robertson et al.   BIOSCIENCE

Comparison of subcutaneous and intraperitoneal injection of d-luciferin for in vivo bioluminescence imaging

(2008) Yusuke Inoue et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

(2008) Hiroki Takeuchi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Arterial Baroreflex Dysfunction Fails to Mimic Parkinson’s Disease in Rats

(2008) Jian-Guang Yu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies

(2007) Charbel E.-H. Moussa et al.   EXPERIMENTAL NEUROLOGY

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments

(2007) Paulien G.M. Ravenstijn et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS