The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

(2018) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

RagC phosphorylation autoregulates mTOR complex 1

(2018) Guang Yang et al.   EMBO JOURNAL

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation

(2017) Wo-Lin Hou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of GRP75 inhibits inflammation in a rat model of intracerebral hemorrhage

(2017) Lian-Jie Lv et al.   Molecular Medicine Reports

Molecular neurobiology of mTOR

(2017) Katarzyna Switon et al.   NEUROSCIENCE

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

(2017) Chang-Ki Oh et al.   Cell Reports

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?

(2017) Gaia Faustini et al.   Genes

Comparative Proteomic Analysis of the Mitochondria-associated ER Membrane (MAM) in a Long-term Type 2 Diabetic Rodent Model

(2017) Jacey Hongjie Ma et al.   Scientific Reports

Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress

(2016) Mingfang Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The unfolded protein response: mechanisms and therapy of neurodegeneration

(2016) Heather L. Smith et al.   BRAIN

Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson’s disease

(2016) Candace H. Carriere et al.   BRAIN RESEARCH

Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers

(2016) M. Morrison Joly et al.   CANCER RESEARCH

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Neuroprotective Role of Insulin Against MPP+-Induced Parkinson's Disease in Differentiated SH-SY5Y Cells

(2015) Mahesh Ramalingam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

AMPK and autophagy in glucose/glycogen metabolism

(2015) Joohun Ha et al.   MOLECULAR ASPECTS OF MEDICINE

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

(2015) Yu-he Yuan et al.   TOXICOLOGY LETTERS

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

(2015) Atossa Shaltouki et al.   Stem Cell Reports

Mis-regulation of Mammalian Target of Rapamycin (mTOR) Complexes Induced by Albuminuria in Proximal Tubules

(2014) Diogo B. Peruchetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Calcium and Endoplasmic Reticulum-Mitochondria Tethering in Neurodegeneration

(2013) Tito Calì et al.   DNA AND CELL BIOLOGY

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

(2012) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

(2012) Yun Chen et al.   CIRCULATION RESEARCH

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

(2012) Peizhou Jiang et al.   NEUROBIOLOGY OF AGING

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Serum starvation: caveat emptor

(2011) Sergej Pirkmajer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease

(2011) Terina N. Martinez et al.   ANTIOXIDANTS & REDOX SIGNALING

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Molecular Basis for the Glycosphingolipid-Binding Specificity of α-Synuclein: Key Role of Tyrosine 39 in Membrane Insertion

(2011) Jacques Fantini et al.   JOURNAL OF MOLECULAR BIOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking organelles apart, putting them back together and creating new ones: Lessons from the endoplasmic reticulum

(2011) Christine Lavoie et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

“Humanized” Stem Cell Culture Techniques: The Animal Serum Controversy

(2011) Chandana Tekkatte et al.   Stem Cells International

Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson’s disease

(2010) Ji Won Um et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple non-cell autonomous actions of α-synuclein in neurodegenerative diseases

(2010) Seung-Jae Lee et al.   CELL CYCLE

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

(2009) Jeroen Poels et al.   BIOESSAYS

Key factors in mTOR regulation

(2009) Xiaochun Bai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

(2009) C. C. Dibble et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular interaction between parkin and PINK1 in mammalian neuronal cells

(2009) Ji Won Um et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson

(2008) Piotr Zabrocki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Overexpression of Mitochondrial Hsp70/Hsp75 in Rat Brain Protects Mitochondria, Reduces Oxidative Stress, and Protects from Focal Ischemia

(2008) Lijun Xu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mortalin: A Protein Associated With Progression of Parkinson Disease?

(2008) Min Shi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS