Contribution of cell death signaling to blood vessel formation

Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

(2020) Zoe L. Grant et al.   JOURNAL OF CLINICAL INVESTIGATION

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

(2019) Hisamichi Naito et al.   DEVELOPMENTAL CELL

BCL-2 family isoforms in apoptosis and cancer

(2019) Chloe F. A. Warren et al.   Cell Death & Disease

TAK1 regulates endothelial cell necroptosis and tumor metastasis

(2019) Lida Yang et al.   CELL DEATH AND DIFFERENTIATION

A non-apoptotic, endothelial barrier-protective role for caspase 3

(2019) Karthik Suresh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Caspase-8 modulates physiological and pathological angiogenesis during retina development

(2019) Nathalie Tisch et al.   JOURNAL OF CLINICAL INVESTIGATION

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3

(2018) Tae-Bong Kang et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis of Endothelial Cells Contributes to Brain Vessel Pruning of Zebrafish During Development

(2018) Yu Zhang et al.   Frontiers in Molecular Neuroscience

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature

(2017) Shoujian Wang et al.   PLoS One

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

(2017) Kay Hänggi et al.   Cell Death & Disease

Plastic roles of pericytes in the blood–retinal barrier

(2017) Do Young Park et al.   Nature Communications

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

CNS Macrophages Control Neurovascular Development via CD95L

(2017) Si Chen et al.   Cell Reports

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

(2017) Uris Ros et al.   Cell Reports

Targeting cell death signalling in cancer: minimising ‘Collateral damage’

(2016) Joanna L Fox et al.   BRITISH JOURNAL OF CANCER

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1

(2016) E C Watson et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis

(2016) Emma C. Watson et al.   DEVELOPMENT

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca 2+ /NFAT Signaling

(2016) Beate Scholz et al.   DEVELOPMENTAL CELL

Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2

(2016) Daniela Siegmund et al.   FEBS Journal

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

Developmental regression of hyaloid vasculature is triggered by neurons

(2016) Yusuke Yoshikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells

(2016) Justyna Sosna et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality

(2016) Cunxian Fan et al.   Cell Death & Disease

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

(2016) Claudio A Franco et al.   eLife

Mechanisms of Vessel Pruning and Regression

(2015) Claudia Korn et al.   DEVELOPMENTAL CELL

Pathophysiology and Mechanisms of Severe Retinopathy of Prematurity

(2015) M. Elizabeth Hartnett   OPHTHALMOLOGY

Endothelium Expression of Bcl-2 Is Essential for Normal and Pathological Ocular Vascularization

(2015) Ismail S. Zaitoun et al.   PLoS One

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

(2015) Soniya Savant et al.   Cell Reports

Endothelial Cell Self-fusion during Vascular Pruning

(2015) Anna Lenard et al.   PLOS BIOLOGY

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

(2015) Claudio A. Franco et al.   PLOS BIOLOGY

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3

(2014) M N Koenig et al.   CELL DEATH AND DIFFERENTIATION

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis

(2014) C. Korn et al.   DEVELOPMENT

Involvement of caspase 8and c-FLIPLin the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)

(2014) Giuseppina Cantarella et al.   FEBS Journal

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

(2014) Nieves Peltzer et al.   Cell Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Development of the human aortic arch system captured in an interactive three-dimensional reference model

(2013) M. Sameer Rana et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions

(2013) Hee-Jun Na et al.   ANGIOGENESIS

Notch controls retinal blood vessel maturation and quiescence

(2013) M. Ehling et al.   DEVELOPMENT

Blood Flow Changes Coincide with Cellular Rearrangements during Blood Vessel Pruning in Zebrafish Embryos

(2013) Eva Kochhan et al.   PLoS One

Pericytes promote selective vessel regression to regulate vascular patterning

(2012) N. Simonavicius et al.   BLOOD

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

(2012) S. Morioka et al.   BLOOD

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Endothelial Cell–Specific FGD5 Involvement in Vascular Pruning Defines Neovessel Fate in Mice

(2012) Caroline Cheng et al.   CIRCULATION

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Proliferative and Survival Effects of PUMA Promote Angiogenesis

(2012) Fan Zhang et al.   Cell Reports

Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish

(2012) Qi Chen et al.   PLOS BIOLOGY

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1

(2011) Felix M. Wensveen et al.   APOPTOSIS

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye

(2011) Cheng Zhang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia

(2010) Shoujian Wang et al.   DEVELOPMENTAL BIOLOGY

Diabetic Retinopathy: Targeting Vasoregression

(2010) H.-P. Hammes et al.   DIABETES

TRAIL-Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization

(2009) Kristin E. Hubert et al.   AMERICAN JOURNAL OF PATHOLOGY

Caspase-3 is activated and rapidly released from human umbilical vein endothelial cells in response to lipopolysaccharide

(2009) Toshikazu Shioiri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

(2009) Li-Kun Phng et al.   DEVELOPMENTAL CELL

Oxygen-induced retinopathy: a model for vascular pathology in the retina

(2009) A Scott et al.   EYE

Proliferative retinopathies: Angiogenesis that blinds

(2009) Przemyslaw Sapieha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2

(2008) Shuji Kondo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

(2008) Wei Qiu et al.   Cell Stem Cell