Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization

Mitotic functions of poly(ADP-ribose) polymerases

(2019) Dea Slade   BIOCHEMICAL PHARMACOLOGY

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Progress in research on paclitaxel and tumor immunotherapy

(2019) Linyan Zhu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

miR-34c-5p modulates X-box–binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response

(2019) Sylwia Bartoszewska et al.   FASEB JOURNAL

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

(2019) Claudia Contadini et al.   Cell Death & Disease

Editorial focus: understanding off-target effects as the key to successful RNAi therapy

(2019) Rafal Bartoszewski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Genome‐wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress

(2019) Rafal Bartoszewski et al.   FEBS Journal

In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab‑paclitaxel on triple‑negative and luminal�A breast cancer cells

(2018) Mehmet Top�ul et al.   ONCOLOGY REPORTS

Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy

(2018) Yanxin Lu et al.   PHARMACOLOGY & THERAPEUTICS

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells

(2017) Roshan L. Shrestha et al.   Nature Communications

Loss of lamin B receptor is necessary to induce cellular senescence

(2016) Emilie Lukášová et al.   BIOCHEMICAL JOURNAL

GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data

(2016) Shani Ben-Ari Fuchs et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Estimation of the lag time in a subsequent monomer addition model for fibril elongation

(2016) Suzanne K. Shoffner et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Near-atomic cryo-EM structure of PRC1 bound to the microtubule

(2016) Elizabeth H. Kellogg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity

(2016) Chenyu Li et al.   Scientific Reports

The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells

(2015) Ewa Augustin et al.   ACTA PHARMACOLOGICA SINICA

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface

(2015) Kara L. McKinley et al.   MOLECULAR CELL

An interconnected hierarchical model of cell death regulation by the BCL-2 family

(2015) Hui-Chen Chen et al.   NATURE CELL BIOLOGY

Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition

(2015) Jun-Mei Yi et al.   Oncotarget

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma

(2015) Véronique Martel-Frachet et al.   Oncotarget

The Novel Tubulin Polymerization Inhibitor MHPT Exhibits Selective Anti-Tumor Activity against Rhabdomyosarcoma In Vitro and In Vivo

(2015) Yan Mu et al.   PLoS One

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7

(2015) Zeran Wang et al.   Oncotarget

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Dynamic assessment of cell viability, proliferation and migration using real time cell analyzer system (RTCA)

(2014) Mani Roshan Moniri et al.   CYTOTECHNOLOGY

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

(2014) J. Bancroft et al.   JOURNAL OF CELL SCIENCE

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

(2014) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

Mangiferin Has an Additive Effect on the Apoptotic Properties of Hesperidin in Cyclopia sp. Tea Extracts

(2014) Rafal Bartoszewski et al.   PLoS One

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

(2014) H. Khoury-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balanced Activity of Three Mitotic Motors Is Required for Bipolar Spindle Assembly and Chromosome Segregation

(2014) Roy G.H.P. van Heesbeen et al.   Cell Reports

CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells

(2013) Monika Pawłowska et al.   ACTA PHARMACOLOGICA SINICA

Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia

(2013) Magdalena Niemira et al.   BIOCHEMICAL PHARMACOLOGY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity

(2013) A. L. Risinger et al.   CANCER RESEARCH

Single-cell sequencing-based technologies will revolutionize whole-organism science

(2013) Ehud Shapiro et al.   NATURE REVIEWS GENETICS

Gas2l3, a Novel Constriction Site-Associated Protein Whose Regulation Is Mediated by the APC/CCdh1 Complex

(2013) Tal Pe’er et al.   PLoS One

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death

(2012) M Seillier et al.   CELL DEATH AND DIFFERENTIATION

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct Cytoplasmic and Nuclear Functions of the Stress Induced Protein DDIT3/CHOP/GADD153

(2012) Alexandra Jauhiainen et al.   PLoS One

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E

(2011) Ying Huang et al.   CELL CYCLE

The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo

(2011) Kageaki Kuribayashi et al.   CELL CYCLE

A Complex of Kif18b and MCAK Promotes Microtubule Depolymerization and Is Negatively Regulated by Aurora Kinases

(2011) Marvin E. Tanenbaum et al.   CURRENT BIOLOGY

Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?

(2010) Adi F. Gazdar et al.   LUNG CANCER

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Phosphorylation of a Borealin Dimerization Domain Is Required for Proper Chromosome Segregation

(2009) Eric Bourhis et al.   BIOCHEMISTRY

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility

(2009) Julie P.I. Welburn et al.   DEVELOPMENTAL CELL

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

(2008) J. Rapley et al.   JOURNAL OF CELL SCIENCE

KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates

(2007) Iain M. Cheeseman et al.   MOLECULAR BIOLOGY OF THE CELL