Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

(2015) A. Scholz et al.   EMBO Molecular Medicine

BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

(2015) Kavi Devraj et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

(2015) Maike Frye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Astrocyte-derived retinoic acid: a novel regulator of blood–brain barrier function in multiple sclerosis

(2014) Mark R. Mizee et al.   ACTA NEUROPATHOLOGICA

Novel insights into the development and maintenance of the blood–brain barrier

(2014) Britta Engelhardt et al.   CELL AND TISSUE RESEARCH

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population

(2013) Roberto Lorbeer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Angiopoietin signaling in the vasculature

(2013) Lauri Eklund et al.   EXPERIMENTAL CELL RESEARCH

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

(2013) Hava Karsenty Avraham et al.   JOURNAL OF PATHOLOGY

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

(2013) Shom Goel et al.   JNCI-Journal of the National Cancer Institute

Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage

(2013) Andrew V. Benest et al.   PLoS One

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Angiopoietin-2 promotes myeloid cell infiltration in a  2-integrin-dependent manner

(2011) A. Scholz et al.   BLOOD

Circulating Angiopoietins-1 and -2, Angiopoietin Receptor Tie-2 and Vascular Endothelial Growth Factor-A as Biomarkers of Acute Myocardial Infarction: a Prospective Nested Case-Control Study

(2011) Carlos Iribarren et al.   BMC Cardiovascular Disorders

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GLUT-1 glucose transporters in the blood-brain barrier: Differential phosphorylation

(2011) Kavi Devraj et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Permeability of Endothelial and Astrocyte Cocultures: In Vitro Blood–Brain Barrier Models for Drug Delivery Studies

(2010) Guanglei Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

VEGFR-1 Signaling Regulates the Homing of Bone Marrow-Derived Cells in a Mouse Stroke Model

(2010) Heike Beck et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Angiogenesis after cerebral ischemia

(2009) Heike Beck et al.   ACTA NEUROPATHOLOGICA

Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice

(2009) Sung-Hee Chang et al.   AMERICAN JOURNAL OF PATHOLOGY

Beyond tie-ing up endothelial adhesion: new insights into the action of angiopoietin-1 in regulation of microvessel permeability

(2009) P. He   CARDIOVASCULAR RESEARCH

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

(2009) Andrew H.J. Salmon et al.   CARDIOVASCULAR RESEARCH

Glycosylation in immune cell trafficking

(2009) Markus Sperandio et al.   IMMUNOLOGICAL REVIEWS

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE