Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

Vascular regulation of antitumor immunity

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Polyamino Acid Layer-by-Layer (LbL) Constructed Silica-Supported Mesoporous Titania Nanocarriers for Stimuli-Responsive Delivery of microRNA 708 and Paclitaxel for Combined Chemotherapy

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Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

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(2017) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

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Functional ferritin nanoparticles for biomedical applications

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Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway

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Metal ion assisted interface re-engineering of a ferritin nanocage for enhanced biofunctions and cancer therapy

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Protease-activated receptors in hemostasis

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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

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Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover

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Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment

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A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

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Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood–brain barrier in vitro

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Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity

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Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption

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The Hippo-YAP signaling pathway and contact inhibition of growth

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Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

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Transactivation of the PAR1-PAR2 Heterodimer by Thrombin Elicits β-Arrestin-mediated Endosomal Signaling

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Protease-activated Receptor 1 (PAR1) and PAR4 Heterodimers Are Required for PAR1-enhanced Cleavage of PAR4 by α-Thrombin

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Intravital analysis of vascular permeability in mice using two-photon microscopy

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Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease

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Vascular Permeability and Drug Delivery in Cancers

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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

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HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

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Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

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The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

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Regulation of RhoGEF proteins by G12/13-coupled receptors

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Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

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Immune surveillance: a balance between protumor and antitumor immunity

(2008) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN GENETICS & DEVELOPMENT