A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

(2021) Keith D. Kauffman et al.   Science Immunology

Mendelian susceptibility to mycobacterial disease: recent discoveries

(2020) Jacinta Bustamante   HUMAN GENETICS

Transcriptome sequencing supports a conservation of macrophage polarization in fish

(2020) Annelieke S. Wentzel et al.   Scientific Reports

The immune landscape in tuberculosis reveals populations linked to disease and latency

(2020) Ekaterina Esaulova et al.   Cell Host & Microbe

Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations

(2019) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection

(2019) Julien Rougeot et al.   Frontiers in Immunology

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit

(2019) Francisco J. Roca et al.   CELL

Cell Type Purification by Single-Cell Transcriptome-Trained Sorting

(2019) Chloé S. Baron et al.   CELL

Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection

(2019) Allison N. Bucşan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Formation and Function of Granulomas

(2018) Antonio J. Pagán et al.   Annual Review of Immunology

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons

(2018) Hanif Esmail et al.   Annual Review of Immunology

A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish

(2018) Roland S. Wu et al.   DEVELOPMENTAL CELL

Impact of immunopathology on the antituberculous activity of pyrazinamide

(2018) Landry Blanc et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation

(2018) Joel D Ernst et al.   JOURNAL OF INFECTIOUS DISEASES

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

(2018) Sabine Ehrt et al.   NATURE REVIEWS MICROBIOLOGY

An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas

(2018) Mark R. Cronan et al.   NATURE METHODS

Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques

(2017) K D Kauffman et al.   Mucosal Immunology

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control ofMycobacterium tuberculosis

(2017) Uma S. Gautam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

(2017) Martin Gengenbacher et al.   Scientific Reports

Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis

(2017) Bibhuti B. Mishra et al.   Nature Microbiology

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

Relationship Between HIV Coinfection, Interleukin 10 Production, andMycobacterium tuberculosisin Human Lymph Node Granulomas

(2016) Collin R. Diedrich et al.   JOURNAL OF INFECTIOUS DISEASES

Inflammatory signaling in human tuberculosis granulomas is spatially organized

(2016) Mohlopheni J Marakalala et al.   NATURE MEDICINE

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

(2016) Shunsuke Sakai et al.   PLoS Pathogens

Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis

(2016) Hlumani Ndlovu et al.   Frontiers in Immunology

CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections

(2015) M. R. Cronan et al.   Disease Models & Mechanisms

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

(2015) Anne Lenaerts et al.   IMMUNOLOGICAL REVIEWS

The association between sterilizing activity and drug distribution into tuberculosis lesions

(2015) Brendan Prideaux et al.   NATURE MEDICINE

CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

(2015) Miguel A Moreno-Mateos et al.   NATURE METHODS

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

(2015) Jan Van den Bossche et al.   Scientific Reports

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

(2015) Brian C. VanderVen et al.   PLoS Pathogens

IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

(2015) Reto Guler et al.   PLoS One

Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro

(2015) Zikun Huang et al.   PLoS One

The IL-13/IL-4Rαaxis is involved in tuberculosis-associated pathology

(2014) Lisa Heitmann et al.   JOURNAL OF PATHOLOGY

Interception of host angiogenic signalling limits mycobacterial growth

(2014) Stefan H. Oehlers et al.   NATURE

Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis

(2014) E. Yaneth Osorio et al.   PLoS Pathogens

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

(2013) Emily S.C. Rittershaus et al.   Cell Host & Microbe

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

An Enzyme That Inactivates the Inflammatory Mediator Leukotriene B4 Restricts Mycobacterial Infection

(2013) David M. Tobin et al.   PLoS One

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

(2013) Li-En Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning

(2013) Isabell Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2

(2012) Yi Feng et al.   CURRENT BIOLOGY

Essential Role of IL-4 and IL-4R  Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates

(2012) L.-y. Zhu et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish

(2012) Mataleena Parikka et al.   PLoS Pathogens

A versatile gene trap to visualize and interrogate the function of the vertebrate proteome

(2011) L. A. Trinh et al.   GENES & DEVELOPMENT

Transcriptional regulation by STAT6

(2011) Shreevrat Goenka et al.   IMMUNOLOGIC RESEARCH

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response

(2011) S. Subbian et al.   Open Biology

Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

(2010) Stephen T. Reece et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Reprogramming in Nonhuman Primate (Rhesus Macaque) Tuberculosis Granulomas

(2010) Smriti Mehra et al.   PLoS One

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

(2009) J. Van den Bossche et al.   BLOOD

Hypoxia: a window intoMycobacterium tuberculosislatency

(2009) Tige R. Rustad et al.   CELLULAR MICROBIOLOGY

Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

(2008) David M. Tobin et al.   CELLULAR MICROBIOLOGY

Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death

(2008) Hilary Clay et al.   IMMUNITY