PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

(2020) Liku B Tezera et al.   eLife

Development of Mycobacterium avium complex lung disease in patients with lung cancer on immune checkpoint inhibitors

(2020) Kohei Fujita et al.   Open Forum Infectious Diseases

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

(2019) Irene Cortese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correlation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus Macaques

(2019) Sivaranjani Namasivayam et al.   mBio

Infectious complications associated with the use of immune checkpoint inhibitors in oncology: reactivation of tuberculosis after anti PD-1 treatment

(2018) H. Picchi et al.   CLINICAL MICROBIOLOGY AND INFECTION

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

(2018) Simon Tiberi et al.   LANCET INFECTIOUS DISEASES

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Paradoxical response in a patient with non-small cell lung cancer who received nivolumab followed by anti- Mycobacterium tuberculosis agents

(2018) So Takata et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis

(2018) Cheryl L. Day et al.   Frontiers in Immunology

Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm

(2017) Martin Rao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Anti–PD-1 Antibody Treatment Promotes Clearance of Persistent Cryptococcal Lung Infection in Mice

(2017) Jonathan A. Roussey et al.   JOURNAL OF IMMUNOLOGY

Pericardial Tamponade Caused by a Hypersensitivity Response to Tuberculosis Reactivation after Anti–PD-1 Treatment in a Patient with Advanced Pulmonary Adenocarcinoma

(2017) Yi-Chun Chu et al.   Journal of Thoracic Oncology

Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques

(2017) K D Kauffman et al.   Mucosal Immunology

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

(2017) Alexander G. White et al.   Jove-Journal of Visualized Experiments

Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy

(2017) Sivaranjani Namasivayam et al.   Microbiome

Tuberculosis reactivation in a patient receiving anti-programmed death-1 (PD-1) inhibitor for relapsed Hodgkin’s lymphoma

(2016) Joycelyn J. X. Lee et al.   ACTA ONCOLOGICA

Anti-PD1 Antibody Treatment and the Development of Acute Pulmonary Tuberculosis

(2016) Kohei Fujita et al.   Journal of Thoracic Oncology

Mice lacking Programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria

(2016) Joshua M. Horne-Debets et al.   Scientific Reports

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

(2016) Shunsuke Sakai et al.   PLoS Pathogens

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

(2016) Cecilia S. Lindestam Arlehamn et al.   PLoS Pathogens

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

(2016) Pushpa Jayaraman et al.   PLoS Pathogens

A Sterilizing Tuberculosis Treatment Regimen Is Associated with Faster Clearance of Bacteria in Cavitary Lesions in Marmosets

(2015) Laura E. Via et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues

(2014) Tetsuya Honda et al.   IMMUNITY

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Modeling Tuberculosis in Nonhuman Primates

(2014) C. A. Scanga et al.   Cold Spring Harbor Perspectives in Medicine

Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis

(2013) Ka-Wing Wong et al.   JOURNAL OF INFECTIOUS DISEASES

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

Biomarker Discovery by Sparse Canonical Correlation Analysis of Complex Clinical Phenotypes of Tuberculosis and Malaria

(2013) Juho Rousu et al.   PLoS Computational Biology

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

(2012) Ravi Dyavar Shetty et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

(2012) Helge Frebel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

(2012) Christian Quast et al.   NUCLEIC ACIDS RESEARCH

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

PD-1-PD-L1 pathway impairs Th1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guerin

(2010) S. Sakai et al.   INTERNATIONAL IMMUNOLOGY

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition

(2010) D. L. Barber et al.   JOURNAL OF IMMUNOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

(2010) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 on dendritic cells impedes innate immunity against bacterial infection

(2009) S. Yao et al.   BLOOD

Target-Dependent B7-H1 Regulation Contributes to Clearance of Central Nervous Sysyem Infection and Dampens Morbidity

(2009) T. W. Phares et al.   JOURNAL OF IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

(2008) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA