Dual-target platinum(IV) complexes exhibit antiproliferative activity through DNA damage and induce ER-stress-mediated apoptosis in A549 cells

Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance

(2020) Zhikun Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Construction of Dual Stimuli-Responsive Platinum(IV) Hybrids with NQO1 Targeting Ability and Overcoming Cisplatin Resistance

(2019) Lei Fang et al.   INORGANIC CHEMISTRY

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo

(2019) Xue-Qing Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel millepachine derivative containing aminophosphonate ester species as novel anti-tubulin agents

(2019) Xiaochao Huang et al.   BIOORGANIC CHEMISTRY

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

(2018) Ke-Bin Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal Drugs and the Anticancer Immune Response

(2018) Bernhard Englinger et al.   CHEMICAL REVIEWS

Conjugation of platinum(IV) complexes with chlorambucil to overcome cisplatin resistance via a “joint action” mode toward DNA

(2017) Xiaodong Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

The Platin-X series: activation, targeting, and delivery

(2016) Uttara Basu et al.   DALTON TRANSACTIONS

Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity

(2016) Hassan Mirzaei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α− N −heterocyclic thiosemicarbazone Fe(III) complex: Characterization of its antitumor activity and identification of anticancer mechanism

(2016) Yi Gou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent Advances in Platinum (IV) Complex-Based Delivery Systems to Improve Platinum (II) Anticancer Therapy

(2015) Xiaopeng Han et al.   MEDICINAL RESEARCH REVIEWS

Synthesis, biological evaluation and molecular docking of novel chalcone–coumarin hybrids as anticancer and antimalarial agents

(2014) Ratchanok Pingaew et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in biological activities of chalcones: A mini review

(2014) Parvesh Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A New Entry to Asymmetric Platinum(IV) Complexes via Oxidative Chlorination

(2014) Mauro Ravera et al.   INORGANIC CHEMISTRY

Discovery of Potent Cytotoxic Ortho-Aryl Chalcones as New Scaffold Targeting Tubulin and Mitosis with Affinity-Based Fluorescence

(2014) Cuige Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors

(2013) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Millepachine, a novel chalcone, induces G 2 /M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo

(2013) Wenshuang Wu et al.   CARCINOGENESIS

The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes

(2013) Chen Qian et al.   Metallomics

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

(2012) Wukun Liu et al.   CHEMICAL SOCIETY REVIEWS

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

(2012) R. J. Boohaker et al.   CURRENT MEDICINAL CHEMISTRY

Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells

(2012) Yung-Lin Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells

(2012) Nora Graf et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

What do we know about the reduction of Pt(IV) pro-drugs?

(2012) Ezequiel Wexselblatt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Benzyl Isothiocyanate (BITC) Induces G2/M Phase Arrest and Apoptosis in Human Melanoma A375.S2 Cells through Reactive Oxygen Species (ROS) and both Mitochondria-Dependent and Death Receptor-Mediated Multiple Signaling Pathways

(2011) Su-Hua Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent

(2009) Yali Kong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

(2009) Romeo Romagnoli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Pt(II) Complexes of a Combretastatin A-4 Analogous Chalcone: Effects of Conjugation on Cytotoxicity, Tumor Specificity, and Long-Term Tumor Growth Suppression

(2008) Rainer Schobert et al.   JOURNAL OF MEDICINAL CHEMISTRY