UBXN7 cofactor of CRL3KEAP1 and CRL2VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins

Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein

(2020) Lucia Cilenti et al.   Scientific Reports

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl fumarate, a two-edged drug: Current status and future directions

(2019) Nathaniel Edward Bennett Saidu et al.   MEDICINAL RESEARCH REVIEWS

NRF2 Activation in Cancer: From DNA to Protein

(2019) Erica W. Cloer et al.   CANCER RESEARCH

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis

(2019) Haoyan Guo et al.   CANCER LETTERS

Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context

(2019) Gregory B. Waypa et al.   EUROPEAN RESPIRATORY JOURNAL

HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer

(2018) Sun-Yong Kim et al.   Autophagy

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

(2018) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intonation of Nrf2 and Hif1-α pathway by curcumin prophylaxis: A potential strategy to augment survival signaling under hypoxia

(2018) Titto Mathew et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

(2017) Shasha Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria

(2017) Janos Steffen et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

(2017) Teresa A.F. Cardote et al.   STRUCTURE

FOXO3 induces ubiquitylation of AKT through MUL1 regulation

(2017) Sun-Yong Kim et al.   Oncotarget

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2

(2016) Zukaa al Taleb et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions

(2016) Jun Peng et al.   MITOCHONDRION

Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells

(2016) Shoichi Nishimoto et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

(2016) Weijia Cai et al.   Cell Division

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming

(2016) Kate E. Hawkins et al.   Cell Reports

The autophagy pathway maintained signaling crosstalk with the Keap1–Nrf2 system through p62 in auditory cells under oxidative stress

(2015) Ken Hayashi et al.   CELLULAR SIGNALLING

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

(2014) Lucia Cilenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP

(2014) Camilla T. Ambivero et al.   CELLULAR SIGNALLING

Role of Compartmentalization on HiF-1α Degradation Dynamics during Changing Oxygen Conditions: A Computational Approach

(2014) Baptiste Bedessem et al.   PLoS One

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

(2014) Jina Yun et al.   eLife

Integrative Genomics Analysis Identifies Candidate Drivers at 3q26-29 Amplicon in Squamous Cell Carcinoma of the Lung

(2013) J. Wang et al.   CLINICAL CANCER RESEARCH

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cullin-RING Ligases as Attractive Anti-cancer Targets

(2013) Yongchao Zhao et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

(2013) Kristie Jenkins et al.   IMMUNOLOGY AND CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

(2013) Rajitha T Kolamunne et al.   Redox Biology

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation

(2012) Susanne Bandau et al.   BMC BIOLOGY

Protein Quality Control in the Intermembrane Space of Mitochondria

(2012) Lena Böttinger et al.   JOURNAL OF MOLECULAR BIOLOGY

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

(2011) M. R. Doe et al.   CANCER RESEARCH

E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53

(2011) J H Jung et al.   CELL DEATH AND DIFFERENTIATION

HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells

(2010) Viktor Malec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress

(2009) Young-Joon Surh et al.   ARCHIVES OF PHARMACAL RESEARCH

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

(2009) Emélie Braschi et al.   EMBO REPORTS

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth

(2008) Bicheng Zhang et al.   CELL RESEARCH

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One