Vascular endothelial cell Toll-like receptor pathways in sepsis

Detailed Characterisation of CB2 Receptor Protein Expression in Peripheral Blood Immune Cells from Healthy Human Volunteers Using Flow Cytometry

(2017) E.S. Graham et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The Anti-Inflammatory Effects of Prostaglandins

(2016) Jose U. Scher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

ERK5 Is a Critical Mediator of Inflammation-Driven Cancer

(2015) K. G. Finegan et al.   CANCER RESEARCH

Toll-Like Receptor 9 Signaling Regulates Tissue Factor and Tissue Factor Pathway Inhibitor Expression in Human Endothelial Cells and Coagulation in Mice

(2015) Driss El Kebir et al.   CRITICAL CARE MEDICINE

TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia

(2015) Susana Martin-Rodriguez et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents

(2015) Elisabeth G.D. Stribos et al.   MOLECULAR IMMUNOLOGY

Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

(2015) Kevin Wilhelmsen et al.   Science Signaling

Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

(2015) Kevin Wilhelmsen et al.   Science Signaling

Hyperglycemia Induces Toll-Like Receptor-2 and -4 Expression and Activity in Human Microvascular Retinal Endothelial Cells: Implications for Diabetic Retinopathy

(2015) Uthra Rajamani et al.   Journal of Diabetes Research

Endothelial cells but not platelets are the major source of Toll-like receptor 4 in the arterial thrombosis and tissue factor expression in mice

(2014) Meiping Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

FSL-1 Induces MMP-9 Production through TLR-2 and NF-κB /AP-1 Signaling Pathways in Monocytic THP-1 Cells

(2014) Rasheed Ahmad et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

The Endocannabinoid/EndovanilloidN-Arachidonoyl Dopamine (NADA) and Synthetic Cannabinoid WIN55,212-2 Abate the Inflammatory Activation of Human Endothelial Cells

(2014) Kevin Wilhelmsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

(2014) A. Pegu et al.   JOURNAL OF IMMUNOLOGY

Varying Importance of Soluble and Membrane CD14 in Endothelial Detection of Lipopolysaccharide

(2014) K. L. Lloyd-Jones et al.   JOURNAL OF IMMUNOLOGY

Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents

(2014) Nhat-Tu Le et al.   JOURNAL OF IMMUNOLOGY

Functional Characterization of S100A8 and S100A9 in Altering Monolayer Permeability of Human Umbilical Endothelial Cells

(2014) Liqun Wang et al.   PLoS One

Similarities and differences in the regulation of leukocyte extravasation and vascular permeability

(2014) Dietmar Vestweber et al.   Seminars in Immunopathology

Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor α-stimulated vascular cell adhesion molecule-1 expression in vascular cells 细胞外信号调节激酶-5：一种新的调节胰岛素与肿瘤坏死因子α刺激下的血管细胞上的血管细胞粘附分子-1表达的介质

(2014) Daniel Z. Mackesy et al.   Journal of Diabetes

Amelioration of Tissue Fibrosis by Toll-like Receptor 4 Knockout in Murine Models of Systemic Sclerosis

(2014) Takehiro Takahashi et al.   Arthritis & Rheumatology

MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response

(2014) Reuben Saba et al.   Frontiers in Immunology

ERK5 Inhibition Ameliorates Pulmonary Fibrosis via Regulating Smad3 Acetylation

(2013) Suji Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

Statins protect human endothelial cells from TNF-induced inflammation via ERK5 activation

(2013) Ke Wu et al.   BIOCHEMICAL PHARMACOLOGY

De-SUMOylation Enzyme of Sentrin/SUMO-Specific Protease 2 Regulates Disturbed Flow–Induced SUMOylation of ERK5 and p53 that Leads to Endothelial Dysfunction and Atherosclerosis

(2013) Kyung-Sun Heo et al.   CIRCULATION RESEARCH

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module

(2013) Gábor Glatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR1/2 Ligand-Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+ T Cell Immunity In Vitro

(2013) J. Liu et al.   JOURNAL OF IMMUNOLOGY

Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1

(2013) Gregory C. Luerman et al.   JOURNAL OF NEUROCHEMISTRY

Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation

(2013) Slava Rom et al.   Journal of Neuroimmune Pharmacology

CX3CL1/CX3CR1 regulates nerve injury-induced pain hypersensitivity through the ERK5 signaling pathway

(2013) Jian-Liang Sun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice

(2013) Huan Gui et al.   MEDIATORS OF INFLAMMATION

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Cellular and molecular regulation of vascular permeability

(2013) Lauren Goddard et al.   THROMBOSIS AND HAEMOSTASIS

Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

(2013) Daniel De Backer et al.   Virulence

Fibrinolytic and coagulative activities of Yersinia pestis

(2013) Timo K. Korhonen et al.   Frontiers in Cellular and Infection Microbiology

Alveolar Macrophages and Toll-like Receptor 4 Mediate Ventilated Lung Ischemia Reperfusion Injury in Mice

(2012) Arun Prakash et al.   ANESTHESIOLOGY

Endothelial RIG-I activation impairs endothelial function

(2012) Tobias Asdonk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes

(2012) Kevin Wilhelmsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEU1 and NEU3 Sialidase Activity Expressed in Human Lung Microvascular Endothelia

(2012) Alan S. Cross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling

(2012) Anthony Virtue et al.   Journal of Hematology & Oncology

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD86 and IL-12p70 Are Key Players for T Helper 1 Polarization and Natural Killer Cell Activation by Toll-Like Receptor-Induced Dendritic Cells

(2012) Felix S. Lichtenegger et al.   PLoS One

A Key Role for the Endothelium in NOD1 Mediated Vascular Inflammation: Comparison to TLR4 Responses

(2012) Timothy Gatheral et al.   PLoS One

Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

(2012) Zenglin Liao et al.   RESPIRATORY RESEARCH

Dissecting negative regulation of Toll-like receptor signaling

(2012) Takeshi Kondo et al.   TRENDS IN IMMUNOLOGY

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway

(2011) Shauna M. Dauphinee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structural Biology of the Toll-Like Receptor Family

(2011) Jin Young Kang et al.   Annual Review of Biochemistry

Mechanisms of Leukocyte Transendothelial Migration

(2011) William A. Muller   Annual Review of Pathology-Mechanisms of Disease

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Staphylococcus aureusphenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

(2011) Lorena Tuchscherr et al.   EMBO Molecular Medicine

Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response

(2011) Kevin Wilhelmsen et al.   Innate Immunity

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10

(2011) M. Mellett et al.   JOURNAL OF IMMUNOLOGY

Innate immunity and coagulation

(2011) C. T. ESMON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MicroRNAs in inflammation and immune responses

(2011) J Contreras et al.   LEUKEMIA

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Bacterial DNA Induces Pulmonary Damage Via TLR-9 Through Cross-talk With Neutrophils

(2011) Kiyoshi Itagaki et al.   SHOCK

PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice

(2011) A. Goolaerts et al.   THORAX

dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts

(2010) G. Farina et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration

(2010) K. Grote et al.   BLOOD

The multiple roles of monocyte subsets in steady state and inflammation

(2010) Clinton S. Robbins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1β, TNF-α, and LPS

(2010) Veronika Makó et al.   CYTOMETRY PART A

The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice

(2010) Trine Bertelsen et al.   EXPERIMENTAL DERMATOLOGY

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Heterogeneous expression of toll-like receptors in lymphatic endothelial cells derived from different tissues

(2010) Emirena Garrafa et al.   IMMUNOLOGY AND CELL BIOLOGY

TLR4 Activation Induces Nontolerant Inflammatory Response in Endothelial Cells

(2010) Wenmeng Wang et al.   INFLAMMATION

Neutrophils: Cinderella of innate immune system

(2010) V. Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Erk5 Activation Elicits a Vasoprotective Endothelial Phenotype via Induction of Krüppel-like Factor 4 (KLF4)

(2010) Nils Ohnesorge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Lipoprotein TLR2 Agonists Broadly Modulate Endothelial Function and Coagulation Pathways In Vitro and In Vivo

(2010) H.-S. Shin et al.   JOURNAL OF IMMUNOLOGY

TLR2- and Nucleotide-Binding Oligomerization Domain 2-Dependent Kruppel-Like Factor 2 Expression Downregulates NF- B-Related Gene Expression

(2010) J. Zahlten et al.   JOURNAL OF IMMUNOLOGY

MEK5 is Activated by Shear Stress, Activates ERK5 and Induces KLF4 to Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells

(2010) PAUL R. CLARK et al.   MICROCIRCULATION

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Expression and regulation of toll-like receptors in cerebral endothelial cells

(2010) Péter Nagyőszi et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular Modeling-Based Evaluation of hTLR10 and Identification of Potential Ligands in Toll-Like Receptor Signaling

(2010) Rajiv Gandhi Govindaraj et al.   PLoS One

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2

(2009) Yuehua Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells

(2009) Noriyuki Hirose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Importance of Being Flexible: The Case of Basic Region Leucine Zipper Transcriptional Regulators

(2009) Maria Miller   CURRENT PROTEIN & PEPTIDE SCIENCE

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

(2009) Puneet Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Signaling mechanism of extracellular RNA in endothelial cells

(2009) Silvia Fischer et al.   FASEB JOURNAL

Cannabinoids as novel anti-inflammatory drugs

(2009) Prakash Nagarkatti et al.   Future Medicinal Chemistry

Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury

(2009) Zubin M. Bamboat et al.   HEPATOLOGY

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal  -Glucans and Toll-Like Receptor Agonists

(2009) H. Huang et al.   INFECTION AND IMMUNITY

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

(2009) Brett Verstak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis

(2009) J. Tschop et al.   JOURNAL OF IMMUNOLOGY

Bacterial DNA Activates Endothelial Cells and Promotes Neutrophil Adherence through TLR9 Signaling

(2009) D. El Kebir et al.   JOURNAL OF IMMUNOLOGY

Translational regulation mechanisms of AP-1 proteins

(2009) Paul Willi Vesely et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Lipoteichoic Acid Induces Unique Inflammatory Responses when Compared to Other Toll-Like Receptor 2 Ligands

(2009) Elizabeth M. Long et al.   PLoS One

Staphylococcus aureus: new evidence for intracellular persistence

(2009) Christian Garzoni et al.   TRENDS IN MICROBIOLOGY

Standardization of real-time PCR gene expression data from independent biological replicates

(2008) Erik Willems et al.   ANALYTICAL BIOCHEMISTRY

Control of mRNA decay by phosphorylation of tristetraprolin

(2008) Heike Sandler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2

(2008) R. L. He et al.   BLOOD

Vessel-Specific Toll-Like Receptor Profiles in Human Medium and Large Arteries

(2008) Olga Pryshchep et al.   CIRCULATION

TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

(2008) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KLF2-dependent, Shear Stress-induced Expression of CD59

(2008) Anne R. Kinderlerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil-derived azurocidin alarms the immune system

(2008) Oliver Soehnlein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression and distribution of Toll-like receptors 11–13 in the brain during murine neurocysticercosis

(2008) Bibhuti B Mishra et al.   Journal of Neuroinflammation

Hemostatic containment – An evolutionary hypothesis of injury by innate immune cells

(2008) Joe Alcock et al.   MEDICAL HYPOTHESES

Human neutrophil–pulmonary microvascular endothelial cell interactions in vitro: Differential effects of nitric oxide vs. peroxynitrite

(2008) Jennifer L. Shelton et al.   MICROVASCULAR RESEARCH

Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides

(2008) Nathalie Satta et al.   MOLECULAR IMMUNOLOGY

Post-transcriptional control of cytokine production

(2008) Paul Anderson   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE