Biological and clinical significance of quorum sensing alkylquinolones: current analytical and bioanalytical methods for their quantification

Development and bioanalytical method validation of an LC-MS/MS assay for simultaneous quantitation of 2-alkyl-4(1H)-quinolones for application in bacterial cell culture and lung tissue

(2020) Luke K. Brewer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enantiomeric separation of quorum sensing autoinducer homoserine lactones using GC-MS and LC-MS

(2020) Elizabeth Readel et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Alternative approaches to treat bacterial infections: targeting quorum-sensing

(2020) Pipat Piewngam et al.   Expert Review of Anti-Infective Therapy

Quorum sensing system: Target to control the spread of bacterial infections

(2020) Erika Kushikawa Saeki et al.   MICROBIAL PATHOGENESIS

High-Throughput Immunochemical Method to Assess the 2-Heptyl-4-quinolone Quorum Sensing Molecule as a Potential Biomarker of Pseudomonas aeruginosa Infections

(2020) Enrique J. Montagut et al.   ACS Infectious Diseases

Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis

(2019) Adam C. Cooke et al.   PLoS One

Anaerobiosis influences virulence properties of Pseudomonas aeruginosa cystic fibrosis isolates and the interaction with Staphylococcus aureus

(2019) Ross Pallett et al.   Scientific Reports

“Three-in-One” SERS Adhesive Tape for Rapid Sampling, Release, and Detection of Wound Infectious Pathogens

(2019) Jingxing Guo et al.   ACS Applied Materials & Interfaces

PQS signaling for more than a quorum: the collective stress response protects healthy Pseudomonas aeruginosa populations

(2019) Julia C. van Kessel   JOURNAL OF BACTERIOLOGY

Electrochemical Detection of Pseudomonas aeruginosa Quorum Sensing Molecules at a Liquid|Liquid Interface

(2019) Edward D. Burgoyne et al.   Journal of Physical Chemistry C

Rapid detection of the bacterial biomarker pyocyanin in artificial sputum using a SERS-active silicon nanowire matrix covered by bimetallic noble metal nanoparticles

(2019) Olga Žukovskaja et al.   TALANTA

Advanced Methods for MALDI-MS Imaging of the Chemical Communication in Microbial Communities

(2019) Eike Ulrich Brockmann et al.   ANALYTICAL CHEMISTRY

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis

(2019) Karmel Webb et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Novel intermicrobial molecular interaction: Pseudomonas aeruginosa Quinolone Signal (PQS) modulates Aspergillus fumigatus response to iron

(2019) Hasan Nazik et al.   MICROBIOLOGY-SGM

The third quorum-sensing system of Pseudomonas aeruginosa: Pseudomonas quinolone signal and the enigmatic PqsE protein

(2019) Selene García-Reyes et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1

(2018) Manoj Kushwaha et al.   ACS Chemical Biology

Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors

(2018) Jan Leipert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantitative SIMS Imaging of Agar-Based Microbial Communities

(2018) Sage J. B. Dunham et al.   ANALYTICAL CHEMISTRY

The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H )-quinolone (PQS) Biosynthesis Enzyme PqsBC

(2018) Florian Witzgall et al.   CHEMBIOCHEM

Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa

(2018) Martina Valentini et al.   CURRENT OPINION IN MICROBIOLOGY

Spatially dependent alkyl quinolone signaling responses to antibiotics inPseudomonas aeruginosaswarms

(2018) Nydia Morales-Soto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of airway epithelial bitter taste receptors byPseudomonas aeruginosaquinolones modulates calcium, cyclic-AMP, and nitric oxide signaling

(2018) Jenna R. Freund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PqsL uses reduced flavin to produce 2-hydroxylaminobenzoylacetate, a preferred PqsBC substrate in alkyl quinolone biosynthesis inPseudomonas aeruginosa

(2018) Steffen Lorenz Drees et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early detection using qPCR of Pseudomonas aeruginosa infection in children with cystic fibrosis undergoing eradication treatment

(2018) Ana C. Blanchard et al.   Journal of Cystic Fibrosis

The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore

(2018) Jinshui Lin et al.   Frontiers in Cellular and Infection Microbiology

Epidemiology, Biology, and Impact of Clonal Pseudomonas aeruginosa Infections in Cystic Fibrosis

(2018) Michael D. Parkins et al.   CLINICAL MICROBIOLOGY REVIEWS

Characterization of thePseudomonas aeruginosaNQR Complex, a Bacterial Proton Pump with Roles in Autopoisoning Resistance

(2018) Daniel A. Raba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PqsE and RhlR proteins are an autoinducer synthase–receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa

(2018) Sampriti Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry

(2018) Emmanuelle E. Bardin et al.   Scientific Reports

Impact of Pseudomonas aeruginosa quorum sensing signaling molecules on adhesion and inflammatory markers in endothelial cells

(2018) Carmen Curutiu et al.   Beilstein Journal of Organic Chemistry

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

(2018) Zheng Pang et al.   BIOTECHNOLOGY ADVANCES

Structural determinants driving homoserine lactone ligand selection in the Pseudomonas aeruginosa LasR quorum-sensing receptor

(2018) Amelia R. McCready et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of the Alkylquinolone Quorum-Sensing System to the Interaction of Pseudomonas aeruginosa With Bronchial Epithelial Cells

(2018) Yi-Chia Liu et al.   Frontiers in Microbiology

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study

(2017) Helen L. Barr et al.   Journal of Cystic Fibrosis

Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC–MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition

(2017) Paul Turnpenny et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

(2017) Jan Leipert et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production

(2017) Roman Popat et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa

(2017) Catalina Florez et al.   mBio

Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection

(2017) Giulia Orazi et al.   mBio

Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus

(2017) Lauren Radlinski et al.   PLOS BIOLOGY

In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp.

(2017) An Hotterbeekx et al.   Frontiers in Cellular and Infection Microbiology

Direct and Rapid Electrochemical Detection ofPseudomonas aeruginosaQuorum Signaling Molecules in Bacterial Cultures and Cystic Fibrosis Sputum Samples through Cationic Surfactant-Assisted Membrane Disruption

(2017) Alyah Buzid et al.   ChemElectroChem

Review of SERS Substrates for Chemical Sensing

(2017) Pamela Mosier-Boss   Nanomaterials

Immunochemical Determination of Pyocyanin and 1-Hydroxyphenazine as Potential Biomarkers of Pseudomonas aeruginosa Infections

(2016) Carme Pastells et al.   ANALYTICAL CHEMISTRY

Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance

(2016) Ronen Hazan et al.   CURRENT BIOLOGY

PqsBC, a Condensing Enzyme in the Biosynthesis of thePseudomonas aeruginosaQuinolone Signal

(2016) Steffen Lorenz Drees et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa

(2016) Giordano Rampioni et al.   PLoS Pathogens

Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability

(2016) Beatrix Tettmann et al.   Frontiers in Microbiology

Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

(2016) Ruan Fourie et al.   Frontiers in Physiology

The role of 2,4-dihydroxyquinoline (DHQ) inPseudomonas aeruginosapathogenicity

(2016) Jordon D. Gruber et al.   PeerJ

Molecular Signature of Pseudomonas aeruginosa with Simultaneous Nanomolar Detection of Quorum Sensing Signaling Molecules at a Boron-Doped Diamond Electrode

(2016) Alyah Buzid et al.   Scientific Reports

Voltammetric profiling of redox-active metabolites expressed by Pseudomonas aeruginosa for diagnostic purposes

(2015) T. Seviour et al.   CHEMICAL COMMUNICATIONS

PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules

(2015) Steffen Lorenz Drees et al.   CHEMISTRY & BIOLOGY

Rapid Detection and Identification of Infectious Pathogens Based on High-throughput Sequencing

(2015) Yun Long et al.   CHINESE MEDICAL JOURNAL

Pseudomonas aeruginosaquorum sensing molecules correlate with clinical status in cystic fibrosis

(2015) Helen L. Barr et al.   EUROPEAN RESPIRATORY JOURNAL

The Pseudomonas Quinolone Signal (PQS)

(2015) Thomas Sams et al.   ISRAEL JOURNAL OF CHEMISTRY

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Role of the Pseudomonas quinolone signal (PQS) in sensitising Pseudomonas aeruginosa to UVA radiation

(2015) Magdalena Pezzoni et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Mass Spectrometry Analysis of Pseudomonas aeruginosa Treated with Azithromycin

(2015) Vanessa V. Phelan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Role of quorum sensing in bacterial infections

(2015) Israel Castillo-Juárez et al.   World Journal of Clinical Cases

MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms

(2014) Eric J. Lanni et al.   ANALYTICAL CHEMISTRY

Augmentation of virulence related traits ofpqsmutants by Pseudomonas quinolone signal through membrane vesicles

(2014) Anju Bala et al.   JOURNAL OF BASIC MICROBIOLOGY

Role ofPseudomonas aeruginosaquorum sensing (QS) molecules on the viability and cytokine profile of human mesenchymal stem cells

(2014) Alina-Maria Holban et al.   Virulence

The hierarchy quorum sensing network in Pseudomonas aeruginosa

(2014) Jasmine Lee et al.   Protein & Cell

The End of an Old Hypothesis: The Pseudomonas Signaling Molecules 4-Hydroxy-2-Alkylquinolines Derive from Fatty Acids, Not 3-Ketofatty Acids

(2013) Carlos Eduardo Dulcey et al.   CHEMISTRY & BIOLOGY

Culture-based diagnostic microbiology in cystic fibrosis: Can we simplify the complexity?

(2013) Jane L. Burns et al.   Journal of Cystic Fibrosis

Polymerase Chain Reaction

(2013) Lilit Garibyan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Development and validation of a UHPLC–MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after acetylation for characterization of new quorum sensing inhibitors

(2013) Christine K. Maurer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The role of two Pseudomonas aeruginosa anthranilate synthases in tryptophan and quorum signal production

(2013) G. C. Palmer et al.   MICROBIOLOGY-SGM

A cell-cell communication signal integrates quorum sensing and stress response

(2013) Jasmine Lee et al.   Nature Chemical Biology

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

(2013) Aravindan Ilangovan et al.   PLoS Pathogens

A Pseudomonas putida bioreporter for the detection of enzymes active on 2-alkyl-4(1H)-quinolone signalling molecules

(2012) Christine Müller et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Analysis of pseudomonas quinolone signal and other bacterial signalling molecules using capillaries coated with highly charged polyelectrolyte monolayers and boron doped diamond electrode

(2012) Lin Zhou et al.   JOURNAL OF CHROMATOGRAPHY A

Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-dependent expression and differential roles in pathogenicity

(2012) D. A. Recinos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour

(2011) F. Jerry Reen et al.   FEMS MICROBIOLOGY ECOLOGY

2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa

(2011) D.-G. Ha et al.   JOURNAL OF BACTERIOLOGY

Dampening Host Sensing and Avoiding Recognition inPseudomonas aeruginosaPneumonia

(2011) Cristina Cigana et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS

(2010) Catharine A. Ortori et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule

(2010) J. Hodgkinson et al.   JOURNAL OF BACTERIOLOGY

The Effect of a Cell-to-Cell Communication Molecule, Pseudomonas Quinolone Signal (PQS), Produced by P. aeruginosa on Other Bacterial Species

(2010) Masanori Toyofuku et al.   MICROBES AND ENVIRONMENTS

Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH

(2010) Jeffrey W. Schertzer et al.   MOLECULAR MICROBIOLOGY

Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes

(2010) G. L. Winsor et al.   NUCLEIC ACIDS RESEARCH

Pseudomonas aeruginosaquorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation

(2009) Mette E. Skindersoe et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-κB pathway

(2009) Kiwan Kim et al.   IMMUNOLOGY

Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples

(2008) Anjali Kumari et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Influence of the Pseudomonas Quinolone Signal on Denitrification in Pseudomonas aeruginosa

(2008) M. Toyofuku et al.   JOURNAL OF BACTERIOLOGY

PqsD Is Responsible for the Synthesis of 2,4-Dihydroxyquinoline, an Extracellular Metabolite Produced byPseudomonas aeruginosa

(2008) Yong-Mei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Influence of Iron onPseudomonas aeruginosaPhysiology

(2008) Amanda G. Oglesby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression

(2008) Lucas R. Hoffman et al.   Journal of Cystic Fibrosis

Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

(2008) Jean-Frédéric Dubern et al.   Molecular BioSystems

Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation

(2008) Lauren Mashburn-Warren et al.   MOLECULAR MICROBIOLOGY

The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations

(2008) Susanne Häussler et al.   PLoS Pathogens