ACE-2 down-regulation may act as a transient molecular disease causing RAAS dysregulation and tissue damage in the microcirculatory environment among COVID-19 patients

Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease

(2021) Zaid Abassi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2

(2021) Weijian Hang et al.   Frontiers of Medicine

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The reproductive number of COVID-19 is higher compared to SARS coronavirus

(2020) Ying Liu et al.   JOURNAL OF TRAVEL MEDICINE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Letter to the Editor: Angiotensin-converting enzyme 2: an ally or a Trojan horse? Implications to SARS-CoV-2-related cardiovascular complications

(2020) Zaid Abassi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

COVID-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome

(2020) Luciano Gattinoni et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series

(2020) Sigurd F. Lax et al.   ANNALS OF INTERNAL MEDICINE

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Coagulopathy of Coronavirus Disease 2019

(2020) Toshiaki Iba et al.   CRITICAL CARE MEDICINE

COVID-19 cytokine storm: The anger of inflammation

(2020) Mehdi Mahmudpour et al.   CYTOKINE

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

(2020) Javier A. Jaimes et al.   JOURNAL OF MOLECULAR BIOLOGY

Angiotensin‐converting enzyme‐2 ( ACE2 ), SARS‐CoV ‐2 and pathophysiology of coronavirus disease 2019 ( COVID ‐19)

(2020) Arno R. Bourgonje et al.   JOURNAL OF PATHOLOGY

Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19

(2020) Marisa Dolhnikoff et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Kidney disease is associated with in-hospital death of patients with COVID-19

(2020) Yichun Cheng et al.   KIDNEY INTERNATIONAL

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abdominal Imaging Findings in COVID-19: Preliminary Observations

(2020) Rajesh Bhayana et al.   RADIOLOGY

MICROVASCULAR THROMBOSIS: EXPERIMENTAL AND CLINICAL IMPLICATIONS

(2020) Monica A. Bray et al.   Translational Research

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

(2020) Alfonso J. Rodriguez-Morales et al.   Travel Medicine and Infectious Disease

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

(2020) Sharon E Fox et al.   Lancet Respiratory Medicine

ACE gene polymorphism and severe lung injury in patients with COVID-19

(2020) Haoyi Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury

(2020) Riccardo Sarzani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

(2020) I. Colmenero et al.   BRITISH JOURNAL OF DERMATOLOGY

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications

(2020) James D. McFadyen et al.   CIRCULATION RESEARCH

COVID-19

(2020) Paolo Verdecchia et al.   HYPERTENSION

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Acro‐ischaemia and COVID‐19 infection: clinical and histopathological features

(2020) J. Calvão et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

In vivo demonstration of microvascular thrombosis in severe COVID-19

(2020) Douglas Alexandre do Espírito Santo et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Intoxication With Endogenous Angiotensin II: A COVID-19 Hypothesis

(2020) Adonis Sfera et al.   Frontiers in Immunology

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection

(2020) Nazzarena Labò et al.   Cells

Immunopathology of Hyperinflammation in COVID-19

(2020) Joshua N. Gustine et al.   AMERICAN JOURNAL OF PATHOLOGY

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities

(2020) Louis Maximilian Buja et al.   CARDIOVASCULAR PATHOLOGY

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review

(2020) Alexander Fletcher-Sandersjöö et al.   THROMBOSIS RESEARCH

COVID-19 – A vascular disease

(2020) Hasan K. Siddiqi et al.   TRENDS IN CARDIOVASCULAR MEDICINE

COVID-19 Usurps Host Regulatory Networks

(2020) Colleen S. Curran et al.   Frontiers in Pharmacology

Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19

(2020) Isabelle Bernard et al.   Viruses-Basel

Thromboinflammation: Challenges of Therapeutically Targeting Coagulation and other Host Defence Mechanisms

(2019) Shaun P. Jackson et al.   BLOOD

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents

(2019) Conrad Fischer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Severe hypertension with renal thrombotic microangiopathy: what happened to the usual suspect?

(2017) Steven Van Laecke et al.   KIDNEY INTERNATIONAL

The role of leukocytes in thrombosis

(2016) Laura L. Swystun et al.   BLOOD

Blood coagulation in immunothrombosis—At the frontline of intravascular immunity

(2016) Florian Gaertner et al.   SEMINARS IN IMMUNOLOGY

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiotensin-(1–9) enhances stasis-induced venous thrombosis in the rat because of the impairment of fibrinolysis

(2013) A Mogielnicki et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

The kinin B1 receptor mediates alloknesis in a murine model of inflammation

(2013) Jumian Feng et al.   NEUROSCIENCE LETTERS

Sepsis and Thrombosis

(2013) Marcus Schultz et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Coagulation and innate immune responses: can we view them separately?

(2009) M. Delvaeye et al.   BLOOD