Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

(2020) C. Martinez Calejman et al.   Nature Communications

Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans

(2020) Ayse Sena Mutlu et al.   Nature Communications

Bacteria-derived metabolite, methylglyoxal, modulates the longevity ofC. elegansthrough TORC2/SGK-1/DAF-16 signaling

(2020) Min-Gi Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A feedback loop governs the relationship between lipid metabolism and longevity

(2020) Nicole K Littlejohn et al.   eLife

Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

(2019) Prasanna V. Ramachandran et al.   DEVELOPMENTAL CELL

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

(2019) Eneda Toska et al.   Cell Reports

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

(2019) Helena Aspernig et al.   Cell Reports

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans

(2018) Blanca Hernando-Rodríguez et al.   BMC BIOLOGY

The UPRmtProtectsCaenorhabditis elegansfrom Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway

(2018) Olga Oks et al.   GENETICS

TOR Complex 2-regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain-containing proteins located at plasma membrane-endoplasmic reticulum contact sites

(2018) Françoise M. Roelants et al.   MOLECULAR BIOLOGY OF THE CELL

The UPRmtProtectsCaenorhabditis elegansfrom Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway

(2018) Olga Oks et al.   GENETICS

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

(2018) Marina Ezcurra et al.   CURRENT BIOLOGY

Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

(2018) Jhee Hong Koh et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex

(2018) Blanca Hernando-Rodríguez et al.   Cells

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

A microRNA program in theC. eleganshypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport

(2016) Robert H. Dowen et al.   GENES & DEVELOPMENT

Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans

(2016) Haizhen Wang et al.   GENETICS

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation

(2016) Lorissa J. Smulan et al.   Cell Reports

Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans

(2016) Haizhen Wang et al.   GENETICS

Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans

(2016) Mohammad M. Rahman et al.   Aging-US

Analysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome

(2015) Artur B. Lourenço et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SREBP and MDT-15 protectC. elegansfrom glucose-induced accelerated aging by preventing accumulation of saturated fat

(2015) Dongyeop Lee et al.   GENES & DEVELOPMENT

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans

(2015) Ming Zhu et al.   PLoS One

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

(2014) Masaki Mizunuma et al.   AGING CELL

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

Effects of 5′-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans

(2014) J.P. Rooney et al.   EXPERIMENTAL GERONTOLOGY

Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

(2014) Roy G. Cutler et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

(2014) Roxani Gatsi et al.   PLoS One

Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans

(2014) Manjunatha Thondamal et al.   Nature Communications

TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation

(2014) Brad J. Niles et al.   Cell Reports

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

(2014) Alexander Muir et al.   eLife

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Autophagy genes are required for normal lipid levels inC. elegans

(2013) Louis R. Lapierre et al.   Autophagy

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans

(2013) Daniel B. Magner et al.   Cell Metabolism

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway

(2013) M. Rauthan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

(2011) Amy K. Walker et al.   CELL

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis

(2010) Erin M Campbell et al.   BMC CELL BIOLOGY

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity

(2010) Hena Alam et al.   Cell Metabolism

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

A Comparative Study of Fat Storage Quantitation in Nematode Caenorhabditis elegans Using Label and Label-Free Methods

(2010) Kelvin Yen et al.   PLoS One

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria

(2009) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

(2009) Marta Artal-Sanz et al.   NATURE

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Prohibitin and mitochondrial biology

(2009) Marta Artal-Sanz et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

(2009) Kevin T Jones et al.   PLOS BIOLOGY

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

The DAF-2 insulin-like signaling pathway independently regulates aging and immunity inC. elegans

(2008) Eric A. Evans et al.   AGING CELL