Aging adipose: Depot location dictates age-associated expansion and dysfunction

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders

(2020) Zhuohao Liu et al.   CLINICAL SCIENCE

Perivascular adipose tissue in age-related vascular disease

(2020) Marcelo Queiroz et al.   AGEING RESEARCH REVIEWS

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

(2020) Hui Gao et al.   Cell Metabolism

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

(2020) Karla J. Suchacki et al.   Nature Communications

Skeletal Muscle Lipid Droplets and the Athlete’s Paradox

(2019) Xuehan Li et al.   Cells

The Impact of Aging on Adipose Function and Adipokine Synthesis

(2019) Peter Mancuso et al.   Frontiers in Endocrinology

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

(2019) Birgit Gustafson et al.   Nature Communications

Brown and Beige Adipose Tissue and Aging

(2019) Elena Zoico et al.   Frontiers in Endocrinology

A dream of single-cell proteomics

(2019) Vivien Marx   NATURE METHODS

Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy

(2019) Shunshun Zhu et al.   PLoS One

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

(2019) Anying Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

(2019) Zhuzhen Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

(2019) Christina D. Camell et al.   Cell Metabolism

Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

(2018) Vuong Cat Khanh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ

(2018) Bo Yu et al.   Cell Stem Cell

Addressing Obesity in Aging Patients

(2018) John A. Batsis et al.   MEDICAL CLINICS OF NORTH AMERICA

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

(2018) Alexander Bartelt et al.   NATURE MEDICINE

Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism

(2018) Antonia Graja et al.   AGING CELL

The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy

(2018) Zhuohao Liu et al.   DIABETES

Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy

(2018) Wenyan Fu et al.   FASEB JOURNAL

Combination of DXA and BIS body composition measurements is highly correlated with physical function—an approach to improve muscle mass assessment

(2018) Adam J. Kuchnia et al.   Archives of Osteoporosis

Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice

(2017) Leidyanne Ferreira Gonçalves et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

(2017) Christina D. Camell et al.   NATURE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans

(2017) Emmani B.M. Nascimento et al.   Obesity

Lsd1 prevents age-programed loss of beige adipocytes

(2017) Delphine Duteil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

(2017) Yuwei Jiang et al.   eLife

The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report

(2017) Rosaly Correa-de-Araujo et al.   Frontiers in Physiology

Skin aging: are adipocytes the next target?

(2016) Ilja L. Kruglikov et al.   Aging-US

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

(2016) Amiya Kumar Ghosh et al.   Aging-US

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity

(2016) Lindsey A. Muir et al.   Obesity

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

(2016) Daniel C. Berry et al.   Nature Communications

Role of Mitochondrial Complex IV in Age-Dependent Obesity

(2016) Ines Soro-Arnaiz et al.   Cell Reports

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

(2016) Michael B. Stout et al.   Aging-US

Metabolic adaptations in the adipose tissue that underlie the body fat mass gain in middle-aged rats

(2015) Rogério Antonio Laurato Sertié et al.   AGE

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

(2015) Erica L. Scheller et al.   Nature Communications

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Aging differentially alters the expression of angiogenic genes in a tissue-dependent manner

(2014) Yoshiaki Shimoda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance

(2014) Soo M. Kim et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Muscle quality index improves with resistance exercise training in older adults

(2014) Maren S. Fragala et al.   EXPERIMENTAL GERONTOLOGY

Intramuscular fat and inflammation differ in older adults: The impact of frailty and inactivity

(2014) Odessa Addison et al.   Journal of Nutrition Health & Aging

The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction

(2014) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging

(2014) Amiya Kumar Ghosh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

An endocrine role for brown adipose tissue?

(2013) Joan Villarroya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

The developmental origins of adipose tissue

(2013) Daniel C. Berry et al.   DEVELOPMENT

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

Orexin Restores Aging-Related Brown Adipose Tissue Dysfunction in Male Mice

(2013) Dyan Sellayah et al.   ENDOCRINOLOGY

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

(2012) Nicole H. Rogers et al.   AGING CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

(2012) Marcelo A. Mori et al.   Cell Metabolism

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

(2012) Mi-Jeong Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Visceral fat and metabolic inflammation: the portal theory revisited

(2012) F. Item et al.   Obesity Reviews

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging

(2011) Águeda González-Rodríguez et al.   AGING CELL

Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function

(2011) Le Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

(2011) Li-Fen Liu et al.   BMC GENOMICS

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice

(2011) C. Jiang et al.   DIABETES

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning

(2011) Anastasia Efimenko et al.   Journal of Translational Medicine

Does the Amount of Fat Mass Predict Age-Related Loss of Lean Mass, Muscle Strength, and Muscle Quality in Older Adults?

(2011) A. Koster et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging alters tissue resident mesenchymal stem cell properties

(2011) Eckhard U. Alt et al.   Stem Cell Research

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

(2010) C. Pfannenberg et al.   DIABETES

Age-associated adaptations in murine adipose tissues

(2010) Bianca Hemmeryckx et al.   ENDOCRINE JOURNAL

Age-dependent impairment of number and angiogenic potential of adipose tissue-derived progenitor cells

(2010) Rosalinda Madonna et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

Macrophage Content in Subcutaneous Adipose Tissue: Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians

(2008) E. Ortega Martinez de Victoria et al.   DIABETES

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY