Hydrogel‐Guided, rAAV‐Mediated IGF‐I Overexpression Enables Long‐Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large‐Animal Full‐Thickness Chondral Defect Model at One Year In Vivo

Full-Thickness Cartilage Defects Are Important Independent Predictive Factors for Progression to Total Knee Arthroplasty in Older Adults with Minimal to Moderate Osteoarthritis

(2019) Joshua S. Everhart et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Surgical and tissue engineering strategies for articular cartilage and meniscus repair

(2019) Heenam Kwon et al.   Nature Reviews Rheumatology

Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno‐Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects

(2019) Henning Madry et al.   ADVANCED MATERIALS

Sustained spatiotemporal release of TGF-β1 confers enhanced very early chondrogenic differentiation during osteochondral repair in specific topographic patterns

(2018) Ann-Kathrin Asen et al.   FASEB JOURNAL

Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair

(2018) Magali Cucchiarini et al.   Nature Reviews Rheumatology

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

(2018) Brett C. Geiger et al.   Science Translational Medicine

Refinement, Reduction, and Replacement (3R) Strategies in Preclinical Testing of Medical Devices

(2018) Victoria A. Hampshire et al.   TOXICOLOGIC PATHOLOGY

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep

(2017) L. Goebel et al.   OSTEOARTHRITIS AND CARTILAGE

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects

(2017) Henning Madry et al.   Stem Cells International

Brief Report: Partial- and Full-Thickness Focal Cartilage Defects Contribute Equally to Development of New Cartilage Damage in Knee Osteoarthritis: The Multicenter Osteoarthritis Study

(2017) Ali Guermazi et al.   Arthritis & Rheumatology

Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair

(2017) Liang Gao et al.   Scientific Reports

Endogenous Cartilage Repair by Recruitment of Stem Cells

(2016) Gun-Il Im   TISSUE ENGINEERING PART B-REVIEWS

Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair

(2016) Ana Rey-Rico et al.   Biomed Research International

Effective genetic modification and differentiation of hMSCs upon controlled release of rAAV vectors using alginate/poloxamer composite systems

(2015) P. Díaz-Rodríguez et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanical properties and structure-function relationships in articular cartilage repaired using IGF-I gene-enhanced chondrocytes

(2015) Darvin J. Griffin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Implantation of rAAV5-IGF-I Transduced Autologous Chondrocytes Improves Cartilage Repair in Full-thickness Defects in the Equine Model

(2015) Kyla F Ortved et al.   MOLECULAR THERAPY

Gene therapy approaches to regenerating the musculoskeletal system

(2015) Christopher H. Evans et al.   Nature Reviews Rheumatology

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

(2014) M Cucchiarini et al.   GENE THERAPY

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells

(2014) Janina Frisch et al.   Stem Cell Research & Therapy

Targeted Delivery to Cartilage Is Critical for In Vivo Efficacy of Insulin-like Growth Factor 1 in a Rat Model of Osteoarthritis

(2014) Francesco S. Loffredo et al.   Arthritis & Rheumatology

Osteochondral tissue regeneration using a bilayered composite hydrogel with modulating dual growth factor release kinetics in a rabbit model

(2013) Kyobum Kim et al.   JOURNAL OF CONTROLLED RELEASE

Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo

(2013) P. Orth et al.   OSTEOARTHRITIS AND CARTILAGE

Reduction of Sample Size Requirements by Bilateral Versus Unilateral Research Designs in Animal Models for Cartilage Tissue Engineering

(2013) Patrick Orth et al.   TISSUE ENGINEERING PART C-METHODS

Self-attaching and cell-attracting in-situ forming dextran-tyramine conjugates hydrogels for arthroscopic cartilage repair

(2012) Liliana S. Moreira Teixeira et al.   BIOMATERIALS

Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

(2012) Magali Cucchiarini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

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(2012) Anja Weimer et al.   MOLECULAR MEDICINE

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

(2012) Jagadeesh K Venkatesan et al.   Stem Cell Research & Therapy

An Arthroscopic Device to Assess Articular Cartilage Defects and Treatment with a Hydrogel

(2010) William J. McCarty et al.   ANNALS OF BIOMEDICAL ENGINEERING

Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair

(2010) R.E. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Basic methods in histopathology of joint tissues

(2010) N. Schmitz et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats

(2010) C.B. Little et al.   OSTEOARTHRITIS AND CARTILAGE

Engineering insulin-like growth factor-1 for local delivery

(2008) Tomotake Tokunou et al.   FASEB JOURNAL

Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined withSox9 viarAAV gene transfer

(2008) Magali Cucchiarini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE