Penetrable Nanoplatform for “Cold” Tumor Immune Microenvironment Reeducation

Turning the corner on therapeutic cancer vaccines

(2019) Robert E. Hollingsworth et al.   npj Vaccines

Tumor Microenvironment‐Triggered Aggregated Magnetic Nanoparticles for Reinforced Image‐Guided Immunogenic Chemotherapy

(2019) Qinjun Chen et al.   Advanced Science

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

(2019) Murugan Kalimutho et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Combining Nanomedicine and Immunotherapy

(2019) Yang Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers

(2018) Gang Zhou et al.   ADVANCED DRUG DELIVERY REVIEWS

Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-Derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy

(2018) Hathaichanok Phuengkham et al.   ADVANCED MATERIALS

Multifunctional Tumor-Targeting Cathepsin B-Sensitive Gemcitabine Prodrug Covalently Targets Albumin in Situ and Improves Cancer Therapy

(2018) Huicong Zhang et al.   BIOCONJUGATE CHEMISTRY

Supramolecular photosensitizers rejuvenate photodynamic therapy

(2018) Xingshu Li et al.   CHEMICAL SOCIETY REVIEWS

Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus

(2018) Lígia C Gomes‐da‐Silva et al.   EMBO JOURNAL

Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Retrosynthesis of multi-component metal−organic frameworks

(2018) Shuai Yuan et al.   Nature Communications

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Gemcitabine nanoparticles promote antitumor immunity against melanoma

(2018) Yuan Zhang et al.   BIOMATERIALS

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Cancer immunotherapy: challenges and clinical applications

(2018) An-Liang Xia et al.   JOURNAL OF MEDICAL GENETICS

High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

(2018) Saman Maleki Vareki   Journal for ImmunoTherapy of Cancer

Immunological therapy: A novel thriving area for triple-negative breast cancer treatment

(2018) Xiangyu Wang et al.   CANCER LETTERS

Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis

(2017) A Tomaru et al.   GENE THERAPY

Cellular immunotherapy of cancer: an overview and future directions

(2017) Ziqi Tao et al.   Immunotherapy

Immunotherapy: Cancer vaccines on the move

(2017) Jacques Banchereau et al.   Nature Reviews Clinical Oncology

Correction to Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice

(2016) Huan Meng et al.   ACS Nano

Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5′-Triphosphate

(2016) Gregory D. McCluskey et al.   CHEMBIOCHEM

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

(2016) Yaqing Zhang et al.   GUT

Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions

(2016) Ryan Ortega et al.   International Journal of Nanomedicine

Size-Controlled Synthesis of Porphyrinic Metal–Organic Framework and Functionalization for Targeted Photodynamic Therapy

(2016) Jihye Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

(2016) Emma Eriksson et al.   Journal of Translational Medicine

Rekindling cancer vaccines

(2016) Malorye Allison Branca   NATURE BIOTECHNOLOGY

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

(2016) Hong-Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Variation in the Incidence and Magnitude of Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes

(2016) Sasha E. Stanton et al.   JAMA Oncology

Periostin induces chemoresistance in colon cancer cells through activation of the PI3K/Akt/survivin pathway

(2015) Zhi-ming Xiao et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Gemcitabine-based therapy for pancreatic cancer using the squalenoyl nucleoside monophosphate nanoassemblies

(2015) Andrei Maksimenko et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

An aptamer-functionalized chemomechanically modulated biomolecule catch-and-release system

(2015) Ankita Shastri et al.   Nature Chemistry

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Conformational structure-dependent molecular recognition of two aptamers for tetracycline

(2015) Sai Wang et al.   RSC Advances

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy

(2014) Andrei Maksimenko et al.   ACS Nano

Signaling pathways involved in MDSC regulation

(2014) Prashant Trikha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Chemotherapeutic Targeting of Cancer-Induced Immunosuppressive Cells

(2014) D. Alizadeh et al.   CANCER RESEARCH

Targeting the bone marrow microenvironment in multiple myeloma

(2014) Yawara Kawano et al.   IMMUNOLOGICAL REVIEWS

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Theranostic Nanoparticles with Controlled Release of Gemcitabine for Targeted Therapy and MRI of Pancreatic Cancer

(2013) Gee Young Lee et al.   ACS Nano

Myeloid-derived suppressor cells in breast cancer

(2013) Joseph Markowitz et al.   BREAST CANCER RESEARCH AND TREATMENT

Hampering Immune Suppressors

(2013) Sabrin Husein Albeituni et al.   CANCER JOURNAL

Periostin-binding DNA Aptamer Inhibits Breast Cancer Growth and Metastasis

(2013) Yu Jin Lee et al.   MOLECULAR THERAPY

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC)

(2012) Suzanne Ostrand-Rosenberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phenotypic Plasticity of MDSC in Cancers

(2012) Masoud H Manjili   IMMUNOLOGICAL INVESTIGATIONS

Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression

(2012) Suzanne Ostrand-Rosenberg et al.   SEMINARS IN CANCER BIOLOGY

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overcoming in vivo barriers to targeted nanodelivery

(2011) Adrian Chrastina et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Design and testing of aptamer-based electrochemical biosensors for proteins and small molecules

(2009) Alan K.H. Cheng et al.   BIOELECTROCHEMISTRY

Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice

(2009) Hanh K. Le et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nanoparticles in photodynamic therapy: An emerging paradigm

(2008) Dev Kumar Chatterjee et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer

(2008) Carolyn E. Clark et al.   CANCER LETTERS