Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis

Pathobiological Subtypes of Alzheimer Disease

(2021) Kurt A. Jellinger   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1)

(2020) Tsunehisa Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype

(2020) Kehui Yang et al.   EUROPEAN HEART JOURNAL

Cardiac Biomarkers in Stroke, Alzheimer’s Disease, and Other Dementia. Are They of Use? A Brief Overview of Data from Recent Investigations

(2020) Shahzad Khan et al.   CNS & Neurological Disorders-Drug Targets

Heart rate response to orthostatic challenge in patients with dementia with L ewy bodies and A lzheimer's disease

(2020) Rie Omoya et al.   Psychogeriatrics

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease

(2020) Feng Zhang et al.   ACTA PHARMACOLOGICA SINICA

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Atrial fibrillation and Alzheimer disease: a conundrum

(2020) Stefano Benenati et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases

(2020) Kerry C. Ryan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

(2020) Cadiele Oliana Reichert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Beclin1 haploinsufficiency rescues low ambient temperature-induced cardiac remodeling and contractile dysfunction through inhibition of ferroptosis and mitochondrial injury

(2020) Zhiqiang Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Ferrous Iron-Dependent Pharmacology

(2020) Ryan L. Gonciarz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases

(2020) Joseph Johnson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Getting to the Heart of Alzheimer Disease

(2019) Joshua M. Tublin et al.   CIRCULATION RESEARCH

Cardiac Abnormalities in Alzheimer Disease

(2019) Giuseppe D. Sanna et al.   JACC-Heart Failure

Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals

(2019) Jun Chen et al.   Frontiers in Neurology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial ALDH2 protects against lipopolysaccharide-induced myocardial contractile dysfunction by suppression of ER stress and autophagy

(2019) Jiaojiao Pang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension

(2019) Yu Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α deacetylation

(2018) Shuyi Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction

(2018) Elizabeth A. Killion et al.   Molecular Metabolism

Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology

(2017) Morgan Robinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Nrf2 Activation by 5-lipoxygenase Metabolites in Human Umbilical Vascular Endothelial Cells

(2017) et al.   Nutrients

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism

(2016) Wei Ge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

(2016) L. Ma et al.   GENETICS AND MOLECULAR RESEARCH

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease

(2016) Luca Troncone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation

(2016) Umesh T. Sankpal et al.   TUMOR BIOLOGY

Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α

(2016) Nan Hu et al.   Oncotarget

HSF1 Relieves Amyloid-β-Induced Cardiomyocytes Apoptosis

(2015) Beiru Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cofilin-2 Phosphorylation and Sequestration in Myocardial Aggregates

(2015) Khaushik Subramanian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Meta-Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Alzheimer's Disease in East Asians

(2014) Pan-Pan Hao et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

The Toxicity Mechanisms of Action of Aβ25–35 in Isolated Rat Cardiac Myocytes

(2014) Beiru Zhang et al.   MOLECULES

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

(2014) Che-Hong Chen et al.   PHYSIOLOGICAL REVIEWS

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Polymorphisms in the aldehyde dehydrogenase 2 and dopamine β hydroxylase genes are not associated with Alzheimer’s disease

(2013) Miwa Komatsu et al.   JOURNAL OF NEURAL TRANSMISSION

Tauroursodeoxycholic Acid Mitigates High Fat Diet-Induced Cardiomyocyte Contractile and Intracellular Ca2+ Anomalies

(2013) Subat Turdi et al.   PLoS One

Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy

(2012) Subat Turdi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Akt Rescues Endoplasmic Reticulum Stress-Impaired Murine Cardiac Contractile Function via Glycogen Synthase Kinase-3β-Mediated Suppression of Mitochondrial Permeation Pore Opening

(2011) Yingmei Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Mitochondrial aldehyde dehydrogenase and cardiac diseases

(2010) Che-Hong Chen et al.   CARDIOVASCULAR RESEARCH

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

Transgenic Overexpression of Aldehyde Dehydrogenase-2 Rescues Chronic Alcohol Intake–Induced Myocardial Hypertrophy and Contractile Dysfunction

(2009) Thomas A. Doser et al.   CIRCULATION

Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients

(2009) Sirui Zhou et al.   NEUROSCIENCE LETTERS

Cardiomyocyte Contractile Dysfunction in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

(2009) Subat Turdi et al.   PLoS One

The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese

(2008) Binbin Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES