Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion

SNARE complex alters the interactions of the Ca2+ sensor synaptotagmin 1 with lipid bilayers

(2021) Maria Bykhovskaia   BIOPHYSICAL JOURNAL

The role of potassium and host calcium signaling in Toxoplasma gondii egress

(2021) Stephen A. Vella et al.   CELL CALCIUM

An Alveolata secretory machinery adapted to parasite host cell invasion

(2021) Eleonora Aquilini et al.   Nature Microbiology

Functions of Vertebrate Ferlins

(2020) Anna V. Bulankina et al.   Cells

A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

(2020) Konstantin Barylyuk et al.   Cell Host & Microbe

The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins

(2020) Hugo Bisio et al.   mBio

Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain

(2020) Clémence Gruget et al.   Scientific Reports

Biogenesis and discharge of the rhoptries: Key organelles for entry and hijack of host cells by the Apicomplexa

(2020) Rouaa Ben Chaabene et al.   MOLECULAR MICROBIOLOGY

Transmission of the malaria parasite requires ferlin for gamete egress from the red blood cell

(2019) Klara Obrova et al.   CELLULAR MICROBIOLOGY

Phosphatidic acid governs natural egress in Toxoplasma gondii via a guanylate cyclase receptor platform

(2019) Hugo Bisio et al.   Nature Microbiology

An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats

(2019) Chandra Ramakrishnan et al.   Scientific Reports

Viral transfer of mini-otoferlins partially restores the fast component of exocytosis and uncovers ultrafast endocytosis in auditory hair cells of otoferlin knock-out mice

(2019) Margot Tertrais et al.   JOURNAL OF NEUROSCIENCE

Biogenesis and secretion of micronemes in Toxoplasma gondii

(2019) David J. Dubois et al.   CELLULAR MICROBIOLOGY

Calcium negatively regulates secretion from dense granules in Toxoplasma gondii

(2019) Nicholas J. Katris et al.   CELLULAR MICROBIOLOGY

Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7

(2019) Hai T. Tran et al.   BIOPHYSICAL JOURNAL

The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid

(2019) Hayley E. Bullen et al.   PLoS Pathogens

Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not Spontaneous Neurotransmitter Release at Neuromuscular Synapses

(2019) Yun Liu et al.   JOURNAL OF NEUROSCIENCE

The roles of Centrin 2 and Dynein Light Chain 8a in apical secretory organelles discharge of Toxoplasma gondii

(2019) Gaëlle Lentini et al.   TRAFFIC

An endocytic-secretory cycle participates in Toxoplasma gondii in motility

(2019) Simon Gras et al.   PLOS BIOLOGY

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

(2019) L. Brock Thornton et al.   PLoS Pathogens

The apical annuli of Toxoplasma gondii are composed of coiled‐coil and signalling proteins embedded in the inner membrane complex sutures

(2019) Klemens Engelberg et al.   CELLULAR MICROBIOLOGY

A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites

(2019) Catherine Suarez et al.   Nature Communications

A highly dynamic F-actin network regulates transport and recycling of micronemes in Toxoplasma gondii vacuoles

(2019) Javier Periz et al.   Nature Communications

SECRETORY ORGANELLE TRAFFICKING IN TOXOPLASMA GONDII : A LONG STORY FOR A SHORT TRAVEL

(2018) Kannan Venugopal et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses

(2018) Tina Pangrsic et al.   FEBS LETTERS

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii

(2018) Alessandro D. Uboldi et al.   PLOS BIOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion

(2018) Bradley I. Coleman et al.   mBio

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels

(2017) Nicole Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

(2017) Nicolas Michalski et al.   eLife

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma

(2016) Hayley E. Bullen et al.   Cell Host & Microbe

A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in apicomplexa

(2016) Hayley E. Bullen et al.   FEBS LETTERS

Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion inToxoplasma gondii

(2016) Kevin M. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins

(2016) Gregory M. I. Redpath et al.   TRAFFIC

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

Lytic Cycle of Toxoplasma gondii: 15 Years Later

(2015) Ira J. Blader et al.   Annual Review of Microbiology

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp

(2015) Sebastian Lourido et al.   CELL CALCIUM

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole

(2015) Daniel A. Gold et al.   Cell Host & Microbe

Toxoplasma secretory granules: one population or more?

(2015) Corinne Mercier et al.   TRENDS IN PARASITOLOGY

Characterization of the Lipid Binding Properties of Otoferlin Reveals Specific Interactions between PI(4,5)P2 and the C2C and C2F Domains

(2014) Murugesh Padmanarayana et al.   BIOCHEMISTRY

Signaling through C2 domains: More than one lipid target

(2014) Senena Corbalan-Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quantitation of the Calcium and Membrane Binding Properties of the C2 Domains of Dysferlin

(2014) Nazish Abdullah et al.   BIOPHYSICAL JOURNAL

Plasmodium falciparum double C2 domain protein, PfDOC2, binds to calcium when associated with membranes

(2014) Sophonie Jean et al.   EXPERIMENTAL PARASITOLOGY

Rapid actin-cytoskeleton–dependent recruitment of plasma membrane–derived dysferlin at wounds is critical for muscle membrane repair

(2014) Joel R. McDade et al.   FASEB JOURNAL

A vacuolar-H+-pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival ofToxoplasma gondii

(2014) Jing Liu et al.   MOLECULAR MICROBIOLOGY

Fast, Ca2+-dependent exocytosis at nerve terminals: Shortcomings of SNARE-based models

(2014) Stephen D. Meriney et al.   PROGRESS IN NEUROBIOLOGY

Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion

(2014) A Defour et al.   Cell Death & Disease

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

The C2 Domains of Otoferlin, Dysferlin, and Myoferlin Alter the Packing of Lipid Bilayers

(2013) Naomi J. Marty et al.   BIOCHEMISTRY

Membrane damage-induced vesicle–vesicle fusion of dysferlin-containing vesicles in muscle cells requires microtubules and kinesin

(2013) Joel R. McDade et al.   HUMAN MOLECULAR GENETICS

Evolutionary repurposing of endosomal systems for apical organelle biogenesis in Toxoplasma gondii

(2013) Stanislas Tomavo   INTERNATIONAL JOURNAL FOR PARASITOLOGY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Calpains, Cleaved Mini-DysferlinC72, and L-Type Channels Underpin Calcium-Dependent Muscle Membrane Repair

(2013) A. Lek et al.   JOURNAL OF NEUROSCIENCE

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole

(2013) Julia D. Romano et al.   MOLECULAR BIOLOGY OF THE CELL

A molecular machine for neurotransmitter release: synaptotagmin and beyond

(2013) Thomas C Südhof   NATURE MEDICINE

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes

(2013) Katrin Kremer et al.   PLoS Pathogens

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

In Vivo Imaging of Molecular Interactions at Damaged Sarcolemma

(2012) Urmas Roostalu et al.   DEVELOPMENTAL CELL

Transcriptomic Analysis of Toxoplasma Development Reveals Many Novel Functions and Structures Specific to Sporozoites and Oocysts

(2012) Heather M. Fritz et al.   PLoS One

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis

(2012) A. Farrell et al.   SCIENCE

Otoferlin: a multi-C2 domain protein essential for hearing

(2012) Tina Pangršič et al.   TRENDS IN NEUROSCIENCES

Toxoplasma Co-opts Host Cells It Does Not Invade

(2012) Anita A. Koshy et al.   PLoS Pathogens

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

The Phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii Reveal Unusual Adaptations Within and Beyond the Parasites' Boundaries

(2011) Moritz Treeck et al.   Cell Host & Microbe

Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

(2011) Régis Nouvian et al.   NATURE NEUROSCIENCE

Doc2 Supports Spontaneous Synaptic Transmission by a Ca2+-Independent Mechanism

(2011) Zhiping P. Pang et al.   NEURON

Ferlins: Regulators of Vesicle Fusion for Auditory Neurotransmission, Receptor Trafficking and Membrane Repair

(2011) Angela Lek et al.   TRAFFIC

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

(2011) Alexander M. Walter et al.   TRENDS IN NEUROSCIENCES

Toxoplasma gondii effectors are master regulators of the inflammatory response

(2011) Mariane B. Melo et al.   TRENDS IN PARASITOLOGY

Role of C2 domain proteins during synaptic vesicle exocytosis

(2010) Sascha Martens   BIOCHEMICAL SOCIETY TRANSACTIONS

RIM proteins and their role in synapse function

(2010) Tobias Mittelstaedt et al.   BIOLOGICAL CHEMISTRY

Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins

(2010) Angela Lek et al.   BMC EVOLUTIONARY BIOLOGY

Cell biology of Ca2+-triggered exocytosis

(2010) Zhiping P Pang et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes

(2010) Dapeng Zhang et al.   GENE

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion

(2010) Colin P. Johnson et al.   JOURNAL OF CELL BIOLOGY

Toxoplasma gondii transmembrane microneme proteins and their modular design

(2010) Lilach Sheiner et al.   MOLECULAR MICROBIOLOGY

DOC2B, C2 Domains, and Calcium: A Tale of Intricate Interactions

(2010) Reut Friedrich et al.   MOLECULAR NEUROBIOLOGY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

(2010) Sebastian Lourido et al.   NATURE

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

(2010) Tina Pangršič et al.   NATURE NEUROSCIENCE

Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release

(2010) A. J. Groffen et al.   SCIENCE

Characterization of Lipid Binding Specificities of Dysferlin C2 Domains Reveals Novel Interactions with Phosphoinositides†

(2009) Christian Therrien et al.   BIOCHEMISTRY

Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell

(2009) P. Heidrych et al.   HUMAN MOLECULAR GENETICS

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

4-Bromophenacyl Bromide Specifically Inhibits Rhoptry Secretion during Toxoplasma Invasion

(2009) Sandeep Ravindran et al.   PLoS One

The Toxoplasma gondii Dense Granule Protein GRA7 Is Phosphorylated upon Invasion and Forms an Unexpected Association with the Rhoptry Proteins ROP2 and ROP4

(2008) J. D. Dunn et al.   INFECTION AND IMMUNITY

Direct Interaction of Otoferlin with Syntaxin 1A, SNAP-25, and the L-type Voltage-gated Calcium Channel CaV1.3

(2008) Neeliyath A. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microneme protein 8 - a new essential invasion factor in Toxoplasma gondii

(2008) H. Kessler et al.   JOURNAL OF CELL SCIENCE

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Accessory Proteins Stabilize the Acceptor Complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 Complex

(2008) Keith Weninger et al.   STRUCTURE

Kiss and spit: the dual roles of Toxoplasma rhoptries

(2007) John C. Boothroyd et al.   NATURE REVIEWS MICROBIOLOGY