Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

Different Ca V 1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells

(2017) Philippe F.Y. Vincent et al.   JOURNAL OF NEUROSCIENCE

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels

(2017) Nicole Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptotagmin 2 Is the Fast Ca 2+ Sensor at a Central Inhibitory Synapse

(2017) Chong Chen et al.   Cell Reports

Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants

(2016) Nicola Strenzke et al.   EMBO JOURNAL

Calcium-induced calcium release supports recruitment of synaptic vesicles in auditory hair cells

(2016) Manuel Castellano-Muñoz et al.   JOURNAL OF NEUROPHYSIOLOGY

The calcium sensor synaptotagmin 7 is required for synaptic facilitation

(2016) Skyler L. Jackman et al.   NATURE

Disruption of adaptor protein 2  (AP-2 ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing

(2015) S. Jung et al.   EMBO JOURNAL

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells

(2015) C. Vogl et al.   JOURNAL OF CELL SCIENCE

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

(2015) Philippe FY Vincent et al.   eLife

Characterization of the Lipid Binding Properties of Otoferlin Reveals Specific Interactions between PI(4,5)P2 and the C2C and C2F Domains

(2014) Murugesh Padmanarayana et al.   BIOCHEMISTRY

Developmental refinement of hair cell synapses tightens the coupling of Ca2+influx to exocytosis

(2014) Aaron B Wong et al.   EMBO JOURNAL

A new probe for super-resolution imaging of membranes elucidates trafficking pathways

(2014) Natalia H. Revelo et al.   JOURNAL OF CELL BIOLOGY

Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells

(2014) Jakob Neef et al.   JOURNAL OF NEUROSCIENCE

Exocytotic Machineries of Vestibular Type I and Cochlear Ribbon Synapses Display Similar Intrinsic Otoferlin-Dependent Ca2+ Sensitivity But a Different Coupling to Ca2+ Channels

(2014) P. F. Y. Vincent et al.   JOURNAL OF NEUROSCIENCE

Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis

(2014) Nikolai M. Chapochnikov et al.   NEURON

Phase-Locking Precision Is Enhanced by Multiquantal Release at an Auditory Hair Cell Ribbon Synapse

(2014) Geng-Lin Li et al.   NEURON

Calcium sensitive ring-like oligomers formed by synaptotagmin

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment

(2014) Huisheng Liu et al.   eLife

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

(2014) Ying Lai et al.   eLife

Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: Correlations with spontaneous rate

(2013) Albena Kantardzhieva et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Calpains, Cleaved Mini-DysferlinC72, and L-Type Channels Underpin Calcium-Dependent Muscle Membrane Repair

(2013) A. Lek et al.   JOURNAL OF NEUROSCIENCE

Disruption of the Presynaptic Cytomatrix Protein Bassoon Degrades Ribbon Anchorage, Multiquantal Release, and Sound Encoding at the Hair Cell Afferent Synapse

(2013) Z. Jing et al.   JOURNAL OF NEUROSCIENCE

Otoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair Cells

(2013) S. V. Duncker et al.   JOURNAL OF NEUROSCIENCE

Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca2+-Calmodulin-Munc13-1 Signaling

(2013) Noa Lipstein et al.   NEURON

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Alternate Splicing of Dysferlin C2A Confers Ca2+-Dependent and Ca2+-Independent Binding for Membrane Repair

(2013) Kerry Fuson et al.   STRUCTURE

STED microscope with Spiral Phase Contrast

(2013) Marcel A. Lauterbach et al.   Scientific Reports

The Auditory Hair Cell Ribbon Synapse: From Assembly to Function

(2012) Saaid Safieddine et al.   Annual Review of Neuroscience

Ca2+ channels and transmitter release at the active zone

(2012) Ralf Schneggenburger et al.   CELL CALCIUM

Transmitter Release from Cochlear Hair Cells Is Phase Locked to Cyclic Stimuli of Different Intensities and Frequencies

(2012) J. D. Goutman   JOURNAL OF NEUROSCIENCE

Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization

(2011) Dong Xu et al.   BIOPHYSICAL JOURNAL

Opposing Gradients of Ribbon Size and AMPA Receptor Expression Underlie Sensitivity Differences among Cochlear-Nerve/Hair-Cell Synapses

(2011) L. D. Liberman et al.   JOURNAL OF NEUROSCIENCE

Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

(2011) Régis Nouvian et al.   NATURE NEUROSCIENCE

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

(2011) Shyam S Krishnakumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calcium-Dependent Synaptic Vesicle Trafficking Underlies Indefatigable Release at the Hair Cell Afferent Fiber Synapse

(2011) Michael E. Schnee et al.   NEURON

Developmental Acquisition of a Rapid Calcium-Regulated Vesicle Supply Allows Sustained High Rates of Exocytosis in Auditory Hair Cells

(2011) Snezana Levic et al.   PLoS One

Ferlins: Regulators of Vesicle Fusion for Auditory Neurotransmission, Receptor Trafficking and Membrane Repair

(2011) Angela Lek et al.   TRAFFIC

Structure Parameters of Synaptic Vesicles Quantified by Small-Angle X-Ray Scattering

(2010) Simon Castorph et al.   BIOPHYSICAL JOURNAL

Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins

(2010) Angela Lek et al.   BMC EVOLUTIONARY BIOLOGY

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion

(2010) Colin P. Johnson et al.   JOURNAL OF CELL BIOLOGY

Onset Coding Is Degraded in Auditory Nerve Fibers from Mutant Mice Lacking Synaptic Ribbons

(2010) B. N. Buran et al.   JOURNAL OF NEUROSCIENCE

Control of Exocytosis by Synaptotagmins and Otoferlin in Auditory Hair Cells

(2010) M. Beurg et al.   JOURNAL OF NEUROSCIENCE

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

(2010) Tina Pangršič et al.   NATURE NEUROSCIENCE

Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell

(2009) P. Heidrych et al.   HUMAN MOLECULAR GENETICS

Otoferlin Is Critical for a Highly Sensitive and Linear Calcium-Dependent Exocytosis at Vestibular Hair Cell Ribbon Synapses

(2009) D. Dulon et al.   JOURNAL OF NEUROSCIENCE

Complexin-I Is Required for High-Fidelity Transmission at the Endbulb of Held Auditory Synapse

(2009) N. Strenzke et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses

(2009) Stuart L Johnson et al.   NATURE NEUROSCIENCE

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

(2009) O.-H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Interaction of Otoferlin with Syntaxin 1A, SNAP-25, and the L-type Voltage-gated Calcium Channel CaV1.3

(2008) Neeliyath A. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY