Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis

GABAergic interneurons in epilepsy: More than a simple change in inhibition

(2020) Joseane Righes Marafiga et al.   EPILEPSY & BEHAVIOR

Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

(2020) Insha Amin et al.   JOURNAL OF FOOD BIOCHEMISTRY

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats

(2019) Xiaolin Deng et al.   Frontiers in Cellular Neuroscience

Pharmacokinetics and Tissue Distribution of Gingerols and Shogaols from Ginger (Zingiber officinale Rosc.) in Rats by UPLC–Q-Exactive–HRMS

(2019) Ling-Ling Li et al.   MOLECULES

Chemopreventive efficacy zingerone (4‐[4‐hydroxy‐3‐methylphenyl] butan‐2‐one) in experimental colon carcinogenesis in Wistar rats

(2019) Majid Ahmad Ganaie et al.   ENVIRONMENTAL TOXICOLOGY

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice

(2019) Zhouqing Wang et al.   Cell Death & Disease

Redox-Related Neuronal Death and Crosstalk as Drug Targets: Focus on Epilepsy

(2019) Xiao-Yuan Mao et al.   Frontiers in Neuroscience

Protective effects of zingerone on cisplatin-induced nephrotoxicity in female rats

(2019) Fatih Mehmet Kandemir et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier K+ Current in Human Prostate Cancer Cells

(2019) Kiran George et al.   JOURNAL OF MEMBRANE BIOLOGY

FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats

(2019) Aihua Wang et al.   Frontiers in Neurology

Cognitive dysfunction after generalized tonic-clonic status epilepticus in adults

(2018) K. N Power et al.   ACTA NEUROLOGICA SCANDINAVICA

Zingerone ameliorates cisplatin‐induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats

(2018) Erdal kaygusuzoglu et al.   BIOMEDICINE & PHARMACOTHERAPY

The Mechanism of Action of Zingerone in the Pacemaker Potentials of Interstitial Cells of Cajal Isolated from Murine Small Intestine

(2018) Jung Nam Kim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

(2018) Chang-Yul Kim et al.   Evidence-based Complementary and Alternative Medicine

Cardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats

(2018) Ahmed F. Soliman et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pathophysiology of status epilepticus

(2018) Matthew C. Walker   NEUROSCIENCE LETTERS

Nephroprotective Effect of Zingerone against CCl4-Induced Renal Toxicity in Swiss Albino Mice: Molecular Mechanism

(2018) Mohammed M. Safhi   Oxidative Medicine and Cellular Longevity

Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy

(2018) Muneeb U. Rehman et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

(2018) Muneeb U Rehman et al.   Current Neuropharmacology

Chemoprotective potential of zingerone (vanillyl acetone) in cyclophosphamide-induced hepatic toxicity

(2018) Manzoor-ur-Rahman Mir et al.   Pharmacognosy Magazine

Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation

(2018) Bilal Ahmad et al.   SAUDI PHARMACEUTICAL JOURNAL

Natural Negative Allosteric Modulators of 5-HT3 Receptors

(2018) Lina T. Al Kury et al.   MOLECULES

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation

(2017) Pallavi B. McElroy et al.   EXPERIMENTAL NEUROLOGY

Metabolic Dysfunction and Oxidative Stress in Epilepsy

(2017) Jennifer Pearson-Smith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of naringenin (A naturally occurring flavanone) against pilocarpine-induced status epilepticus and oxidative stress in mice

(2017) Nahida Tabassum et al.   Pharmacognosy Magazine

Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy

(2017) Antoine K. Kandeda et al.   Frontiers in Pharmacology

Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage

(2016) Summya Rashid et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) Protects Against Acetaminophen Induced Hepatotoxicity in Wistar Rats via Alleviation of Oxidative Stress and Inflammation

(2016) Bilal Ahmad et al.  

Recent advances in status epilepticus

(2016) Eugen Trinka et al.   CURRENT OPINION IN NEUROLOGY

Antioxidant and anti-inflammatory role of zingerone in ethanol-induced hepatotoxicity

(2016) Vijay Mani et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Myeloperoxidase Nuclear Imaging for Epileptogenesis

(2016) Yinian Zhang et al.   RADIOLOGY

Status epilepticus: Using antioxidant agents as alternative therapies

(2016) Liliana Carmona-Aparicio et al.   Experimental and Therapeutic Medicine

Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons

(2016) Erika R. Kinjo et al.   Scientific Reports

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

(2015) Bostjan Martinc et al.   Current Neuropharmacology

Pharmacotherapy for Status Epilepticus

(2015) Eugen Trinka et al.   DRUGS

A definition and classification of status epilepticus - Report of the ILAE Task Force on Classification of Status Epilepticus

(2015) Eugen Trinka et al.   EPILEPSIA

Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale

(2015) Kevin D. Phelan et al.   EPILEPSY RESEARCH

Why is nitric oxide important for our brain?

(2015) E Džoljić   FUNCTIONAL NEUROLOGY

The Role of Flavonoids on Oxidative Stress in Epilepsy

(2015) Tâmara Coimbra Diniz et al.   Oxidative Medicine and Cellular Longevity

A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone)

(2015) Bilal Ahmad et al.   TheScientificWorldJOURNAL

Seizures and Epilepsy: An Overview for Neuroscientists

(2015) C. E. Stafstrom et al.   Cold Spring Harbor Perspectives in Medicine

A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone)

(2015) Bilal Ahmad et al.   Scientific World Journal

Neuropsychological deficits in temporal lobe epilepsy: A comprehensive review

(2014) Priyanka Rastogi et al.   Annals of Indian Academy of Neurology

Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice

(2014) Abdolkarim Hosseini et al.   EPILEPSY RESEARCH

Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats

(2014) Summya Rashid et al.   FOOD AND CHEMICAL TOXICOLOGY

Role of Inflammatory Mediators in the Pathogenesis of Epilepsy

(2014) Tadayuki Shimada et al.   MEDIATORS OF INFLAMMATION

Oxidative Stress Associated with Neuronal Apoptosis in Experimental Models of Epilepsy

(2014) Marisela Méndez-Armenta et al.   Oxidative Medicine and Cellular Longevity

Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures

(2014) Ana Paula dos S.C.L. da Silva et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Zingerone Protects Against Stannous Chloride-Induced and Hydrogen Peroxide-Induced Oxidative DNA Damage In Vitro

(2013) Iyappan Rajan et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Zingerone enhances glutamatergic spontaneous excitatory transmission by activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa

(2013) Hai-Yuan Yue et al.   JOURNAL OF NEUROPHYSIOLOGY

Involvement of the Nitric Oxide/Cyclic Guanylate Monophosphate Pathway in the Pilocarpine-Induced Seizure Model in Mice

(2013) Emiliano Ricardo Vasconcelos Rios et al.   PHARMACOLOGY

Delayed administration of zingerone mitigates the behavioral and histological alteration via repression of oxidative stress and intrinsic programmed cell death in focal transient ischemic rats

(2013) Kumar Vaibhav et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Molecular mechanisms of antiseizure drug activity at GABAA receptors

(2013) L. John Greenfield   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Ion channels in genetic and acquired forms of epilepsy

(2012) Holger Lerche et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis

(2012) Yehudit Gnatek et al.   Frontiers in Molecular Neuroscience

Mitochondrial dysfunction in epilepsy

(2011) Jaroslava Folbergrová et al.   MITOCHONDRION

Effects of Zingerone [4-(4-Hydroxy-3-Methoxyphenyl)-2-Butanone] and Eugenol [2-Methoxy-4-(2-Propenyl)Phenol] on the Pathological Progress in the 6-Hydroxydopamine-Induced Parkinson’s Disease Mouse Model

(2011) Hideaki Kabuto et al.   NEUROCHEMICAL RESEARCH

Role of oxidative stress in epileptic seizures

(2011) Eun-Joo Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead

(2010) Chan-Min Liu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY