The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1

Secondary Prevention for Atherosclerotic Cardiovascular Disease

(2020) Salim S. Virani et al.   CIRCULATION

Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet

(2020) Lei Xu et al.   Evidence-based Complementary and Alternative Medicine

Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2

(2020) Xiaojie Liao et al.   Molecular Medicine Reports

Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE−/− mice and inhibits the activation of CD4+ T cells

(2020) Liyu Zhou et al.   Nutrition & Metabolism

Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway

(2020) Mengyue Yang et al.   Oxidative Medicine and Cellular Longevity

MicroRNA-200a Inhibits Inflammation and Atherosclerotic Lesion Formation by Disrupting EZH2-Mediated Methylation of STAT3

(2020) Jinpeng Wang et al.   Frontiers in Immunology

Endothelial to Mesenchymal Transition in Cardiovascular Disease

(2019) Jason C. Kovacic et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease

(2019) Donna K. Arnett et al.   CIRCULATION

Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway

(2019) Dongming Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Resveratrol improves endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice

(2019) Jinghua Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary Fiber, Atherosclerosis, and Cardiovascular Disease

(2019) Ghada A. Soliman   Nutrients

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

(2019) Celine Souilhol et al.   Nature Reviews Cardiology

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

Targeting of EZH2 inhibits epithelial‑mesenchymal transition in head and neck squamous cell carcinoma via regulating the STAT3/VEGFR2 axis

(2019) Minghui Zhao et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events

(2019) Amir Ahmadi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Complexity of PRC2 Subcomplexes

(2019) Guido van Mierlo et al.   TRENDS IN CELL BIOLOGY

Quercetin has a protective effect on atherosclerosis via enhancement of autophagy in ApoE‑/‑ mice

(2019) Hui Cao et al.   Experimental and Therapeutic Medicine

SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition

(2019) Zhen-Hua Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites

(2019) J. Nie et al.   JOURNAL OF APPLIED MICROBIOLOGY

Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome

(2019) Giuseppina Piazzolla et al.   Diabetology & Metabolic Syndrome

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

(2019) Stevan D Stojanović et al.   EUROPEAN HEART JOURNAL

The timeline of epigenetic drug discovery: from reality to dreams

(2019) A. Ganesan et al.   Clinical Epigenetics

Knockdown of GAS5 Inhibits Atherosclerosis Progression via Reducing EZH2-Mediated ABCA1 Transcription in ApoE−/− Mice

(2019) Xiang-Dong Meng et al.   Molecular Therapy-Nucleic Acids

Selective inhibition of endothelial NF-κB signaling attenuates chronic intermittent hypoxia-induced atherosclerosis in mice

(2018) Dongmei Song et al.   ATHEROSCLEROSIS

Endothelial–mesenchymal transition in atherosclerosis

(2018) Celine Souilhol et al.   CARDIOVASCULAR RESEARCH

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis

(2018) Carla Winter et al.   Cell Metabolism

Potential of anti-inflammatory agents for treatment of atherosclerosis

(2018) Dimitry A. Chistiakov et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

SIRT1 inhibits TGF-β-induced endothelial-mesenchymal transition in human endothelial cells with Smad4 deacetylation

(2018) Zhen Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

(2018) Hao Wu et al.   JOURNAL OF ENDOCRINOLOGY

Chlorogenic Acid Protects Against oxLDL-Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

(2018) Kun-Ling Tsai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis

(2018) M. Wesseling et al.   VASCULAR PHARMACOLOGY

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects

(2018) Suowen Xu et al.   Theranostics

The Epithelial-to-Mesenchymal Transition in Cancer

(2018) Joëlle Roche   Cancers

Endothelial-to-mesenchymal transition shapes the atherosclerotic plaque and modulates macrophage function

(2018) Alexandra Helmke et al.   FASEB JOURNAL

High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

(2018) Xingbo Xu et al.   Nature Communications

Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat

(2018) Mark Lipphardt et al.   Frontiers in Physiology

Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence

(2018) Hong Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Medical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome

(2018) Guglielmo Gallone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity

(2017) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis

(2017) Carlo Patrono et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antihypertensive drugs

(2017) Stéphane Laurent   PHARMACOLOGICAL RESEARCH

Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice

(2017) Aleksandr E. Vendrov et al.   Journal of the American Heart Association

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

(2017) Ee Soo Lee et al.   Scientific Reports

Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence

(2017) Fumihiro Sanada et al.   Scientific Reports

The Different Therapeutic Choices with ARBs. Which One to Give? When? Why?

(2016) Csaba András Dézsi   American Journal of Cardiovascular Drugs

EZH2 promotes invasion and metastasis of laryngeal squamous cells carcinoma via epithelial-mesenchymal transition through H3K27me3

(2016) HuaNan Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques

(2016) Anna Greißel et al.   CARDIOVASCULAR PATHOLOGY

TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and AtherosclerosisNovelty and Significance

(2016) Marwa M. Mahmoud et al.   CIRCULATION RESEARCH

Effect of treatment with 5-lipoxygenase inhibitor VIA-2291 (atreleuton) on coronary plaque progression: a serial CT angiography study

(2016) Suguru Matsumoto et al.   CLINICAL CARDIOLOGY

Residual inflammatory risk: addressing the obverse side of the atherosclerosis prevention coin

(2016) Paul M Ridker   EUROPEAN HEART JOURNAL

2016 European Guidelines on cardiovascular disease prevention in clinical practice

(2016) Massimo F. Piepoli et al.   EUROPEAN HEART JOURNAL

Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions

(2016) Michael G. Silverman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nutraceutical therapies for atherosclerosis

(2016) Joe W. E. Moss et al.   Nature Reviews Cardiology

Role of the EZH2 histone methyltransferase as a therapeutic target in cancer

(2016) Antoine Italiano   PHARMACOLOGY & THERAPEUTICS

Resveratrol Protects against TNF-α-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK

(2016) Wei Pan et al.   PLoS One

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

(2016) David Cano-Rodriguez et al.   Nature Communications

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Endothelial Plasticity: Shifting Phenotypes through Force Feedback

(2016) Guido Krenning et al.   Stem Cells International

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

(2016) Sokrates Stein et al.   Aging-US

Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis

(2016) Yun-Cheng Lv et al.   PLoS One

Hyperhomocysteinemia in ApoE-/- Mice Leads to Overexpression of Enhancer of Zeste Homolog 2 via miR-92a Regulation

(2016) Yang Xiaoling et al.   PLoS One

Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

(2015) Dorota Gurda et al.   AMINO ACIDS

The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence

(2015) Monika Maleszewska et al.   ANGIOGENESIS

Involvement of Interleukin-1 Receptor-Associated Kinase-1 in Vascular Smooth Muscle Cell Proliferation and Neointimal Formation After Rat Carotid Injury

(2015) M. Jain et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response

(2015) Yi xi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

(2015) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Sirtuins in Epigenetic Regulation

(2015) Hui Jing et al.   CHEMICAL REVIEWS

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2015) Martin Bennett et al.   CIRCULATION

First-in-man Study With Inclacumab, a Human Monoclonal Antibody Against P-selectin

(2015) Christophe Schmitt et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation

(2015) Ching-Hsia Hung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma

(2015) Serena Vella et al.   Clinical Epigenetics

SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence

(2014) Yan-Zhen Wan et al.   AGING CELL

Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway

(2014) Hui Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of ERK5 in endothelial cell function

(2014) Gopika N. Nithianandarajah-Jones et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes MellitusCLINICAL PERSPECTIVE

(2014) Francesco Paneni et al.   Circulation-Cardiovascular Genetics

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

(2014) Melroy X. Miranda et al.   EUROPEAN HEART JOURNAL

Anti-inflammatory therapies for cardiovascular disease

(2014) P. M. Ridker et al.   EUROPEAN HEART JOURNAL

Lipid lowering with PCSK9 inhibitors

(2014) Razvan T. Dadu et al.   Nature Reviews Cardiology

Gene Expression Analyses of Mouse Aortic Endothelium in Response to Atherogenic Stimuli

(2013) Ayca Erbilgin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Histone and DNA Methylation–Mediated Epigenetic Downregulation of Endothelial Kruppel-Like Factor 2 by Low-Density Lipoprotein Cholesterol

(2013) Ajay Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HDL and endothelial protection

(2013) A Tran-Dinh et al.   BRITISH JOURNAL OF PHARMACOLOGY

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo

(2013) Peter F. Davies et al.   CARDIOVASCULAR RESEARCH

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults

(2013) Paul A. James et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peripheral Blood Monocyte Sirt1 Expression Is Reduced in Patients with Coronary Artery Disease

(2013) Alexander Breitenstein et al.   PLoS One

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers

(2013) Sowmya Venkatasubramanian et al.   Journal of the American Heart Association

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18

(2012) Anthony J. Valente et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure

(2012) Z. Wu et al.   BLOOD

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen

(2012) Paul M Ridker et al.   CIRCULATION

A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis

(2012) Nhat-Tu Le et al.   CIRCULATION

Epigenetic Regulation of Cell Adhesion and Communication by Enhancer of Zeste Homolog 2 in Human Endothelial Cells

(2012) Henryk Dreger et al.   HYPERTENSION

Quercetin alleviates hypercholesterolemic diet induced inflammation during progression and regression of atherosclerosis in rabbits

(2012) Shobha Bhaskar et al.   NUTRITION

Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence

(2012) HouZao Chen et al.   Science China-Life Sciences

Atherosclerosis: from biology to pharmacological treatment

(2012) Riccioni Graziano et al.   Journal of Geriatric Cardiology

Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

(2011) Harald Schuett et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models

(2011) Robert Kleemann et al.   ATHEROSCLEROSIS

Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation

(2011) H.-J. Wei et al.   CARDIOVASCULAR RESEARCH

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

(2011) et al.   EUROPEAN HEART JOURNAL

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

(2011) Chung-Lan Kao et al.   Journal of Atherosclerosis and Thrombosis

Anti-inflammatory therapeutics for the treatment of atherosclerosis

(2011) Israel F. Charo et al.   NATURE REVIEWS DRUG DISCOVERY

Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2

(2011) Michiel Smits et al.   PLoS One

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

(2010) Sokrates Stein et al.   EUROPEAN HEART JOURNAL

A-002 (Varespladib), a phospholipase A2inhibitor, reduces atherosclerosis in guinea pigs

(2009) Jose O Leite et al.   BMC Cardiovascular Disorders

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype

(2009) J. Gracia-Sancho et al.   CARDIOVASCULAR RESEARCH

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis

(2009) Magnus Back   CURRENT PHARMACEUTICAL DESIGN

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Serum Lipid and Blood Pressure Responses to Quercetin Vary in Overweight Patients by Apolipoprotein E Genotype

(2009) Sarah Egert et al.   JOURNAL OF NUTRITION

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cytokines and atherosclerosis: a comprehensive review of studies in mice

(2008) R. Kleemann et al.   CARDIOVASCULAR RESEARCH

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

Effects of the Direct Lipoprotein-Associated Phospholipase A 2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque

(2008) Patrick W. Serruys et al.   CIRCULATION

Oxidative Modification of LDL: Its Pathological Role in Atherosclerosis

(2008) Hiroyuki Itabe   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

(2008) Q Cao et al.   ONCOGENE

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

(2007) Yann Wallez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES