High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

(2016) Sumiyo Morita et al.   NATURE BIOTECHNOLOGY

Epigenetic mechanisms in neurogenesis

(2016) Bing Yao et al.   NATURE REVIEWS NEUROSCIENCE

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

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A CRISPR-based approach for targeted DNA demethylation

(2016) Xingxing Xu et al.   Cell Discovery

Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis

(2015) Xingbo Xu et al.   CARDIOVASCULAR RESEARCH

Endocardial Fibroelastosis Is Caused by Aberrant Endothelial to Mesenchymal Transition

(2015) X. Xu et al.   CIRCULATION RESEARCH

Heterozygous deletion of the LRFN2 gene is associated with working memory deficits

(2015) Julien Thevenon et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Tumor Suppressor Activity of Klotho in Breast Cancer Is Revealed by Structure-Function Analysis

(2015) H. Ligumsky et al.   MOLECULAR CANCER RESEARCH

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

(2015) Lauren R Polstein et al.   Nature Chemical Biology

Functional annotation of native enhancers with a Cas9–histone demethylase fusion

(2015) Nicola A Kearns et al.   NATURE METHODS

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

(2015) Pratiksha I Thakore et al.   NATURE METHODS

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

(2015) Xiao-Hui Zhang et al.   Molecular Therapy-Nucleic Acids

Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease

(2015) Björn Tampe et al.   EBioMedicine

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

(2015) Manuel Stemmer et al.   PLoS One

Hypermethylation and Clinicopathological Significance of RASAL1 Gene in Gastric Cancer

(2014) Hong Chen et al.   Asian Pacific Journal of Cancer Prevention

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

(2014) B. Tampe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Potential approaches to reverse or repair renal fibrosis

(2014) Desiree Tampe et al.   Nature Reviews Nephrology

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of RASAL1 as a Major Tumor Suppressor Gene in Thyroid Cancer

(2013) D. Liu et al.   JNCI-Journal of the National Cancer Institute

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases

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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

(2013) Morgan L Maeder et al.   NATURE BIOTECHNOLOGY

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA methylation dynamics in health and disease

(2013) Yehudit Bergman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter

(2013) Hui Chen et al.   NUCLEIC ACIDS RESEARCH

PGC7 suppresses TET3 for protecting DNA methylation

(2013) C. Bian et al.   NUCLEIC ACIDS RESEARCH

Klotho Acts as a Tumor Suppressor in Cancers

(2013) Biao Xie et al.   PATHOLOGY & ONCOLOGY RESEARCH

Promoter methylation confers kidney-specific expression of the Klotho gene

(2012) Masahiro Azuma et al.   FASEB JOURNAL

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells

(2012) FENGCHANG QIAO et al.   ONCOLOGY REPORTS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats

(2011) Hui Tao et al.   TOXICOLOGY

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

(2010) Slobodan Beronja et al.   NATURE MEDICINE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

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