Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative Diseases

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

(2020) Natalia Moskal et al.   Nature Communications

The relationship between ANT1 and NFL with autophagy and mitophagy markers in patients with multiple sclerosis

(2020) Mehdi Hassanpour et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders

(2020) Sonia Missiroli et al.   Journal of Clinical Medicine

Ca2+ Fluxes and Cancer

(2020) Saverio Marchi et al.   MOLECULAR CELL

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

(2020) Kahori Shiba-Fukushima et al.   iScience

Evaluation of the Diagnostic and Predictive Value of Serum Levels of ANT1, ATG5, and Parkin in Multiple Sclerosis

(2020) Omid Joodi khanghah et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

The induction of AMPK-dependent autophagy leads to P53 degradation and affects cell growth and migration in kidney cancer cells

(2020) Simone Patergnani et al.   EXPERIMENTAL CELL RESEARCH

IRGM promotes the PINK1‐mediated mitophagy through the degradation of Mitofilin in SH‐SY5Y cells

(2020) Xize Guo et al.   FASEB JOURNAL

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

(2020) Jiaming Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dichotomous Role of Inflammation in the CNS: A Mitochondrial Point of View

(2020) Bianca Vezzani et al.   Biomolecules

ESCRT machinery plays a role in microautophagy in yeast

(2020) Shamsul Morshed et al.   BMC Molecular and Cell Biology

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

(2019) Hans Lassmann   Frontiers in Immunology

Blood-based molecular biomarkers for Alzheimer’s disease

(2019) Henrik Zetterberg et al.   Molecular Brain

Functional Effects of Cuprizone-Induced Demyelination in the Presence of the mTOR-Inhibitor Rapamycin

(2019) Hana Yamate-Morgan et al.   NEUROSCIENCE

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Interplay between Mitophagy and inflammasome in Neurological Disorders

(2019) Radhika Kesharwani et al.   ACS Chemical Neuroscience

Rapamycin activates mammalian microautophagy

(2019) Masahiro Sato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

(2019) Jonas Walter et al.   Stem Cell Reports

Mitochondrial DNA: the overlooked oncogenome?

(2019) Payam A. Gammage et al.   BMC BIOLOGY

Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients

(2019) Massimiliano Castellazzi et al.   Journal of Neuroinflammation

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease

(2019) Simon Sjödin et al.   Alzheimers Research & Therapy

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

(2019) Jianqun Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GDF-15, a mitochondrial disease biomarker, is associated with the severity of multiple sclerosis

(2019) Seitaro Nohara et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

(2019) Helena Aspernig et al.   Cell Reports

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

(2019) Kai Chang et al.   Autophagy

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

(2018) Xu Hou et al.   Autophagy

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

CSF lamp2 concentrations are decreased in female Parkinson’s disease patients with LRRK2 mutations

(2018) Andrea C. Klaver et al.   BRAIN RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients

(2018) Verica Paunovic et al.   JOURNAL OF NEUROIMMUNOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease

(2018) Yasuo Miki et al.   NEUROBIOLOGY OF AGING

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

(2018) Charleen T. Chu   NEUROBIOLOGY OF DISEASE

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

(2018) Albert A. Davis et al.   Annual Review of Cell and Developmental Biology

The TORC1–Nem1/Spo7–Pah1/lipin axis regulates microautophagy induction in budding yeast

(2018) Muhammad Arifur Rahman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

(2018) Anna Picca et al.   Nature Reviews Cardiology

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Promising effect of rapamycin on multiple sclerosis

(2018) Bahram Bagherpour et al.   Multiple Sclerosis and Related Disorders

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation

(2018) Hallvard L. Olsvik et al.   Autophagy

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

(2018) Juliane Becher et al.   DEVELOPMENTAL CELL

Cerebrospinal Fluid Levels of Autophagy-related Proteins Represent Potentially Novel Biomarkers of Early-Stage Parkinson’s Disease

(2018) Jinyoung Youn et al.   Scientific Reports

Tau Pathology in Parkinson's Disease

(2018) Xue Zhang et al.   Frontiers in Neurology

Multiple ways to prevent transmission of paternal mitochondrial DNA for maternal inheritance in animals

(2017) Ken Sato et al.   JOURNAL OF BIOCHEMISTRY

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy and mitophagy elements are increased in body fluids of multiple sclerosis-affected individuals

(2017) Simone Patergnani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease

(2017) Adam L. Orr et al.   NEUROCHEMISTRY INTERNATIONAL

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of Autophagy Causes Tau Proteolysis by Activating Calpain in Rat Brain

(2017) Jia-yu Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

(2017) Johan Sundelöf et al.   JOURNAL OF ALZHEIMERS DISEASE

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms

(2017) Tibor Kovács et al.   Scientific Reports

Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagy

(2016) Satoru Torii et al.   EMBO REPORTS

Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells

(2016) Masahiro Sato et al.   GENES TO CELLS

The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations

(2016) Clément A. Gautier et al.   HUMAN MOLECULAR GENETICS

Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies

(2016) Alessandro Rimessi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression

(2016) Maria Albanese et al.   Journal of Neuroinflammation

Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease

(2016) M. Rodríguez-Arribas et al.   MOLECULAR NEUROBIOLOGY

Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease

(2016) Angela Pyle et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease

(2016) Petar Podlesniy et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

(2016) Sonia Missiroli et al.   Cell Reports

Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid

(2016) Andrea Boman et al.   Journal of Parkinsons Disease

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

(2016) Antonio Piras et al.   Acta Neuropathologica Communications

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

(2015) Jon Sin et al.   Autophagy

AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects

(2015) Diána Papp et al.   Autophagy

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

(2015) Patricia Martín-Maestro et al.   HUMAN MOLECULAR GENETICS

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Evidence for polymerase gamma, POLG1 variation in reduced mitochondrial DNA copy number in Parkinson's disease

(2015) Ya-Xing Gui et al.   PARKINSONISM & RELATED DISORDERS

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy

(2015) Simone Patergnani et al.   Frontiers in Oncology

Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up

(2015) Arnaud François et al.   PLoS One

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders

(2014) O. V. Forlenza et al.   ACS Chemical Neuroscience

A New Model of Cuprizone-Mediated Demyelination/Remyelination

(2014) Hilary H. Sachs et al.   ASN Neuro

Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

(2014) M Bonora et al.   CELL DEATH AND DIFFERENTIATION

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

New Multiple Sclerosis Phenotypic Classification

(2014) Fred D. Lublin   EUROPEAN NEUROLOGY

Deficiency of Autophagy in Dendritic Cells Protects against Experimental Autoimmune Encephalomyelitis

(2014) Abhisek Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation

(2013) Yuriy Chaban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

Dendritic cells treated with chloroquine modulate experimental autoimmune encephalomyelitis

(2013) Rodolfo Thomé et al.   IMMUNOLOGY AND CELL BIOLOGY

Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool

(2013) Vito Iacobazzi et al.   MOLECULAR GENETICS AND METABOLISM

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

(2013) Samuel A. Hasson et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease

(2013) Andrea Armstrong et al.   NEUROMOLECULAR MEDICINE

Chloroquine Treatment Enhances Regulatory T Cells and Reduces the Severity of Experimental Autoimmune Encephalomyelitis

(2013) Rodolfo Thomé et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients

(2012) Erin Harberts et al.   Journal of Neuroimmune Pharmacology

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

(2012) L. Lisi et al.   JOURNAL OF NEUROIMMUNOLOGY

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

(2012) Katrin Beyer et al.   MOLECULAR NEUROBIOLOGY

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features

(2012) Eleanna Kara et al.   NEUROBIOLOGY OF AGING

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

(2011) Markus Bach et al.   BIOCHEMICAL JOURNAL

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

(2011) Aleksandar Rakovic et al.   PLoS One

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells

(2010) Hongwei Xu et al.   FASEB JOURNAL

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

Autophagy Induction by the Pathogen Receptor CD46

(2009) Pierre-Emmanuel Joubert et al.   Cell Host & Microbe

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

T-cell regulation by CD46 and its relevance in multiple sclerosis

(2008) Anne L. Astier   IMMUNOLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 mutations and parkinsonism

(2008) L. Ishihara-Paul et al.   NEUROLOGY