Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

(2015) Carlotta Giorgi et al.   Oncotarget

Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling

(2015) Bingqing Huang et al.   Oncotarget

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer

(2014) Andrew Poklepovic et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondria: from cell death executioners to regulators of cell differentiation

(2014) Atsuko Kasahara et al.   TRENDS IN CELL BIOLOGY

Autophagy in Kidney Health and Disease

(2013) Zhibo Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Perturbed mitochondrial Ca2+signals as causes or consequences of mitophagy induction

(2013) Alessandro Rimessi et al.   Autophagy

PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy

(2013) Simone Patergnani et al.   Autophagy

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Autophagy and cell death

(2013) Tohru Yonekawa et al.   Essays in Biochemistry

Beclin-1: Autophagic regulator and therapeutic target in cancer

(2013) Lei-lei Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nilotinib Induces Autophagy in Hepatocellular Carcinoma through AMPK Activation

(2013) Hui-Chuan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3 Mimetics: Status of the Field and New Developments

(2013) C. Billard   MOLECULAR CANCER THERAPEUTICS

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling

(2013) A Rimessi et al.   ONCOGENE

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

PP2A regulates autophagy in two alternative ways in Drosophila

(2012) Ágnes Bánréti et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

(2012) Amandine Magnaudeix et al.   NEUROBIOLOGY OF AGING

PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations

(2012) Z Yao et al.   ONCOGENE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis

(2012) S Marchi et al.   Cell Death & Disease

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

(2011) Flavie Strappazzon et al.   EMBO JOURNAL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease

(2010) C. T. Chu   HUMAN MOLECULAR GENETICS

Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status

(2010) Francesca Buontempo et al.   INVESTIGATIONAL NEW DRUGS

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

(2009) M. Lebiedzinska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Lipophagy: Selective Catabolism Designed for Lipids

(2009) Hilla Weidberg et al.   DEVELOPMENTAL CELL

PGC-1α activation as a therapeutic approach in mitochondrial disease

(2009) Tina Wenz   IUBMB LIFE

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

(2008) Saverio Marchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional coactivators PGC-1  and PGC-l  control overlapping programs required for perinatal maturation of the heart

(2008) L. Lai et al.   GENES & DEVELOPMENT

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY