Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice

(2018) Nobuyuki Nishizawa et al.   JOURNAL OF HEPATOLOGY

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth

(2018) Anna Kock et al.   EBioMedicine

Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer

(2018) Matthew Saldana et al.   ENDOCRINE-RELATED CANCER

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer

(2016) Z. Hall et al.   CANCER RESEARCH

OpenMS: a flexible open-source software platform for mass spectrometry data analysis

(2016) Hannes L Röst et al.   NATURE METHODS

Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition

(2016) Yong Li et al.   Thoracic Cancer

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib

(2015) Y Jin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity

(2015) Federica Finetti et al.   ENDOCRINE-RELATED CANCER

Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment

(2015) Karin Larsson et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis

(2014) Antonio Checa et al.   Multiple Sclerosis Journal

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

MS-GF+ makes progress towards a universal database search tool for proteomics

(2014) Sangtae Kim et al.   Nature Communications

Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells

(2013) R. Takahashi et al.   BIOMEDICINE & PHARMACOTHERAPY

Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

(2013) Robert Ramer et al.   JOURNAL OF LIPID RESEARCH

Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice

(2013) Helena Idborg et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation

(2013) Patrick Leclerc et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis

(2013) Louise R. Howe et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Thromboxane A2 receptor α promotes tumor growth through an autoregulatory feedback pathway

(2013) Run-Yue Huang et al.   Journal of Molecular Cell Biology

Indomethacin-Enhanced Anticancer Effect of Arsenic Trioxide in A549 Cell Line: Involvement of Apoptosis and Phospho-ERK and p38 MAPK Pathways

(2013) Ali Mandegary et al.   Biomed Research International

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

(2012) Ioanna Sevastou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PES1 promotes breast cancer by differentially regulating ERα and ERβ

(2012) Long Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis

(2012) Simon Ekman et al.   Journal of Thoracic Oncology

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect

(2011) Tomoko Kato et al.   BIOCHEMICAL PHARMACOLOGY

The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis

(2011) Prasanna Ekambaram et al.   CANCER AND METASTASIS REVIEWS

Selective PGE2 Suppression Inhibits Colon Carcinogenesis and Modifies Local Mucosal Immunity

(2011) M. Nakanishi et al.   Cancer Prevention Research

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide

(2011) Qing Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland

(2011) Jenean OBrien et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

NS398 induces apoptosis in non-small cell lung cancer cells

(2011) Rong Qiu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Probabilistic Consensus Scoring Improves Tandem Mass Spectrometry Peptide Identification

(2011) Sven Nahnsen et al.   JOURNAL OF PROTEOME RESEARCH

Potential molecular targets in chemopreventative action of celecoxib: a proteomics analysis of J774.A1 macrophage-like cell line

(2011) Faegheh Rezaie et al.   Molecular BioSystems

Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer

(2011) Mary-Clare Cathcart et al.   Molecular Cancer

Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis

(2011) Y Sasaki et al.   ONCOGENE

Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma

(2011) T. Murata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dihydroceramide desaturase activity is modulated by oxidative stress

(2010) Jolanta Idkowiak-Baldys et al.   BIOCHEMICAL JOURNAL

PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer

(2010) Margaret C Keightley et al.   BMC CANCER

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Co-Overexpression of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Adversely Affects the Postoperative Survival in Non-small Cell Lung Cancer

(2010) Yu-Chung Wu et al.   Journal of Thoracic Oncology

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

(2009) Daisuke Kamei et al.   BIOCHEMICAL JOURNAL

Prostaglandin F2 -F-Prostanoid Receptor Signaling Promotes Neutrophil Chemotaxis via Chemokine (C-X-C Motif) Ligand 1 in Endometrial Adenocarcinoma

(2009) A. E. Wallace et al.   CANCER RESEARCH

Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells

(2009) Jun Li et al.   CANCER SCIENCE

Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production

(2009) Ian L.P. Beales et al.   INTERNATIONAL JOURNAL OF CANCER

Proteomic analysis in NSAIDs-treated primary cardiomyocytes

(2009) Seon Mi Baek et al.   Journal of Proteomics

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

(2009) H. Hanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexity ofCOX-2gene regulation: Figure 1

(2008) Kelly A. Harper et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prostacyclin Prevents Murine Lung Cancer Independent of the Membrane Receptor by Activation of Peroxisomal Proliferator-Activated Receptor  

(2008) R. Nemenoff et al.   Cancer Prevention Research

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice

(2008) Christian Brenneis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

(2008) Susanne Schiffmann et al.   JOURNAL OF LIPID RESEARCH

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

(2008) D. Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

(2008) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms

(2008) Hanna Eriksson et al.   PROTEOMICS