Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2?

Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice

(2020) Shuying Miao et al.   Frontiers in Physiology

DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1

(2020) Shuo Zhou et al.   Scientific Reports

Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis

(2020) Julianne N. P. Smith et al.   Scientific Reports

miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer

(2019) Nicholas J. Monteleone et al.   Scientific Reports

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells

(2019) Filip Bergqvist et al.   Frontiers in Pharmacology

A review on mPGES-1 inhibitors: From preclinical studies to clinical applications

(2019) Filip Bergqvist et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

(2018) Jaismy Jacob P et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells

(2018) Jie Yin et al.   HEART AND VESSELS

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

(2018) Kai Ding et al.   Scientific Reports

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth

(2018) Anna Kock et al.   EBioMedicine

Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas

(2018) Kota Arima et al.   ONCOGENE

Diclofenac use and cardiovascular risks: series of nationwide cohort studies

(2018) Morten Schmidt et al.   BMJ-British Medical Journal

Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor

(2018) Rajaram Azad et al.   FITOTERAPIA

MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma

(2018) Young Soo Park et al.   Scientific Reports

Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells

(2017) Rui Chen et al.   INFLAMMATION

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair

(2017) Monika I. Antczak et al.   JOURNAL OF MEDICINAL CHEMISTRY

In-vitro wound healing effect of 15-hydroxyprostaglandin dehydrogenase inhibitor from plant

(2017) Sandeep Karna   Pharmacognosy Magazine

Prostaglandin terminal synthases as novel therapeutic targets

(2017) Shuntaro HARA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Increased expression of tight junction protein�occludin is associated with the protective effect of mosapride against aspirin‑induced gastric injury

(2017) Chenchen Liu et al.   Experimental and Therapeutic Medicine

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury

(2017) Lu Yao et al.   PLoS One

Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective

(2016) Carlo Patrono   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial

(2016) Ema Washio et al.   Clinical Gastroenterology and Hepatology

Curcumin Blocks Naproxen-Induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats

(2016) Jeong-Hwan Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

(2015) Andreas Koeberle et al.   BIOCHEMICAL PHARMACOLOGY

The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages

(2015) Tomasz Olszowski et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?

(2015) G O'Callaghan et al.   BRITISH JOURNAL OF PHARMACOLOGY

15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes

(2015) HAK-JAE KIM et al.   Molecular Medicine Reports

Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

(2015) Nicholas S. Kirkby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclooxygenase-1 as the Main Source of Proinflammatory Factors After Sodium Orthovanadate Treatment

(2014) Jan Korbecki et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Cardiovascular Risk with Non-steroidal Anti-inflammatory Drugs: Clinical Implications

(2014) Alfonso E. Bello et al.   DRUG SAFETY

Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system

(2014) Zhihua Yue et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Fluoride in low concentration modifies expression and activity of 15 lipoxygenase in human PBMC differentiated monocyte/macrophage

(2012) I. Gutowska et al.   TOXICOLOGY

Inibição seletiva da ciclo-oxigenase-2: riscos e benefícios

(2012) Reila Tainá Mendes et al.   Revista Brasileira De Reumatologia

Identification and development of mPGES-1 inhibitors: where we are at?

(2011) Hui-Hua Chang et al.   Future Medicinal Chemistry

mPGES-1 as a target for cancer suppression

(2010) Masako Nakanishi et al.   BIOCHIMIE

Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report

(2009) Marco Zaffanello et al.   ACTA PAEDIATRICA

Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

(2009) D. Bharat Reddy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Eicosanoids in inflammation and cancer: the role of COX-2

(2009) Smita Agarwal et al.   Expert Review of Clinical Immunology

Prostaglandin E2 at new glance: Novel insights in functional diversity offer therapeutic chances

(2009) Daniel F. Legler et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chebulagic acid, a COX–LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line

(2009) D. Bharat Reddy et al.   JOURNAL OF ETHNOPHARMACOLOGY

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS