Peritumoral Microenvironment in High-Grade Gliomas: From FLAIRectomy to Microglia–Glioma Cross-Talk

State of the art of fluorescence guided techniques in neurosurgery

(2020) Giuseppe La Rocca et al.   Journal of Neurosurgical Sciences

Supramarginal resection of glioblastoma: 5-ALA fluorescence, combined intraoperative strategies and correlation with survival

(2020) Francesco Certo et al.   Journal of Neurosurgical Sciences

Radiation Damage to Tumor Vasculature Initiates a Program that Promotes Tumor Recurrences

(2020) J. Martin Brown   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Effects of supra-total resection in neurocognitive and oncological outcome of high-grade gliomas comparing asleep and awake surgery

(2020) Luca Zigiotto et al.   JOURNAL OF NEURO-ONCOLOGY

5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. A Case-Based Update and Literature Review

(2020) Giuseppe La Rocca et al.   World Neurosurgery

Safety metric profiling in surgery for temporal glioblastoma: lobectomy as a supra-total resection regime preserves perioperative standard quality rates

(2020) Matthias Schneider et al.   JOURNAL OF NEURO-ONCOLOGY

miR-504 modulates the stemness and mesenchymal transition of glioma stem cells and their interaction with microglia via delivery by extracellular vesicles

(2020) Ariel Bier et al.   Cell Death & Disease

Microglia-Centered Combinatorial Strategies Against Glioblastoma

(2020) Tomás A. Martins et al.   Frontiers in Immunology

FLAIRectomy in Supramarginal Resection of Glioblastoma Correlates With Clinical Outcome and Survival Analysis: A Prospective, Single Institution, Case Series

(2020) Francesco Certo et al.   Operative Neurosurgery

Identification of extracellular vesicles and characterization of miRNA expression profiles in human blastocoel fluid

(2019) R. Battaglia et al.   Scientific Reports

The role of microglia in viral encephalitis: a review

(2019) Zhuangzhuang Chen et al.   Journal of Neuroinflammation

Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region

(2019) Haihui Jiang et al.   JOURNAL OF NEUROSURGERY

Survival benefit of lobectomy over gross-total resection without lobectomy in cases of glioblastoma in the noneloquent area: a retrospective study

(2019) Tae Hoon Roh et al.   JOURNAL OF NEUROSURGERY

Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

(2019) Alessio D’Alessio et al.   Cancers

Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury

(2019) Dai Li et al.   NEUROCHEMICAL RESEARCH

5-Aminolevulinic Acid Fluorescence Guided-Resection of 18F-FET-PET Positive Tumor Beyond Gadolinium Enhancing Tumor Improves Survival in Glioblastoma

(2019) Michael Müther et al.   NEUROSURGERY

Microglia

(2019) Valeria Carola et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Harnessing Microglia and Macrophages for the Treatment of Glioblastoma

(2019) Ioanna Prionisti et al.   Frontiers in Pharmacology

The Immune Landscape of Cancer

(2019) Vésteinn Thorsson et al.   IMMUNITY

Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib, overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme

(2019) Zhenzhe Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

(2019) Erik R. Abels et al.   Cell Reports

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

Supramaximal resection: A systematic review of its safety, efficacy and feasibility in glioblastoma

(2019) James Dimou et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Deep sequencing and automated histochemistry of human tissue slice cultures improve their usability as preclinical model for cancer research

(2019) Susann Haehnel et al.   Scientific Reports

let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7

(2019) Alice Buonfiglioli et al.   Cell Reports

Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients

(2018) Yen-Ying Chen et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

(2018) M Monticelli et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Comparative dynamics of microglial and glioma cell motility at the infiltrative margin of brain tumours

(2018) Joseph Juliano et al.   Journal of the Royal Society Interface

Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment

(2018) Aparna Karthikeyan et al.   Oncotarget

Noncoding RNAs in Health and Disease

(2018) Davide Barbagallo et al.   International Journal of Genomics

Extending the resection beyond the contrast-enhancement for glioblastoma: feasibility, efficacy, and outcomes

(2018) David Mampre et al.   BRITISH JOURNAL OF NEUROSURGERY

Circulating miR-26a and miR-21 as biomarkers for glioblastoma multiform

(2018) Monireh ParvizHamidi et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas

(2018) Pia S. Zeiner et al.   BRAIN PATHOLOGY

Exosomal miR-214-5p released from glioblastoma cells modulates inflammatory response of microglia after LPS stimulation through targeting CXCR5

(2018) Jian-kai Yang et al.   CNS & Neurological Disorders-Drug Targets

Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma

(2018) Banavathy S. Kruthika et al.   JOURNAL OF NEURO-ONCOLOGY

Glioblastoma: Microenvironment and Niche Concept

(2018) Davide Schiffer et al.   Cancers

Microglia-glioma cross-talk a two way approach to new strategies against glioma

(2017) Cataldo Arcuri   Frontiers in Bioscience-Landmark

Maximize surgical resection beyond contrast-enhancing boundaries in newly diagnosed glioblastoma multiforme: is it useful and safe? A single institution retrospective experience

(2017) Federico Pessina et al.   JOURNAL OF NEURO-ONCOLOGY

Tumor location and patient age predict biological signatures of high-grade gliomas

(2017) Roberto Altieri et al.   NEUROSURGICAL REVIEW

5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins

(2017) James L. Ross et al.   Scientific Reports

Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer

(2017) Marco Ragusa et al.   International Journal of Genomics

Imaging Dendrimer-Grafted Graphene Oxide Mediated Anti-miR-21 Delivery With an Activatable Luciferase Reporter

(2016) Fu Wang et al.   ACS Applied Materials & Interfaces

Epigenetic dysregulation in neuroblastoma: A tale of miRNAs and DNA methylation

(2016) Federica Parodi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A restricted signature of serum miRNAs distinguishes glioblastoma from lower grade gliomas

(2016) Giulia Regazzo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?

(2016) Yan Michael Li et al.   JOURNAL OF NEUROSURGERY

A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas

(2016) Darryl Lau et al.   JOURNAL OF NEUROSURGERY

miRNAs Plasma Profiles in Vascular Dementia: Biomolecular Data and Biomedical Implications

(2016) Marco Ragusa et al.   Frontiers in Cellular Neuroscience

Supra-complete surgery via dual intraoperative visualization approach (DiVA) prolongs patient survival in glioblastoma

(2016) Ilker Y. Eyüpoglu et al.   Oncotarget

Long-term outcomes after supratotal resection of diffuse low-grade gliomas: a consecutive series with 11-year follow-up

(2015) Hugues Duffau   ACTA NEUROCHIRURGICA

miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma

(2015) Pietro Ivo D’Urso et al.   CURRENT GENOMICS

In Vivo Detection of miRNA Expression in Tumors Using an Activatable Nanosensor

(2015) Byunghee Yoo et al.   MOLECULAR IMAGING AND BIOLOGY

Comprehensive analysis of microRNA expression profile in malignant glioma tissues

(2015) Monika Piwecka et al.   Molecular Oncology

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

Microgliosis in the Injured Brain

(2015) Ting Li et al.   NEUROSCIENTIST

The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors

(2015) Barbara Fazi et al.   Oncotarget

Proinflammatory-Activated Glioma Cells Induce a Switch in Microglial Polarization and Activation Status, From a Predominant M2b Phenotype to a Mixture of M1 and M2a/B Polarized Cells

(2014) Lucia Lisi et al.   ASN Neuro

Detection of miRNA Expression in Intact Cells Using Activatable Sensor Oligonucleotides

(2014) Byunghee Yoo et al.   CHEMISTRY & BIOLOGY

The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype

(2014) Lucia Lisi et al.   Journal of Neuroinflammation

Serum MicroRNA-125b as a Potential Biomarker for Glioma Diagnosis

(2014) XiangTai Wei et al.   MOLECULAR NEUROBIOLOGY

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

(2014) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies

(2013) Anna Carolina Carvalho da Fonseca et al.   Clinical & Developmental Immunology

Review: Molecular mechanism of microglia stimulated glioblastoma invasion

(2013) Salvatore J. Coniglio et al.   MATRIX BIOLOGY

Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN

(2013) X.-R. Wang et al.   NEURO-ONCOLOGY

Gene Expression Profile of Glioblastoma Peritumoral Tissue: An Ex Vivo Study

(2013) Annunziato Mangiola et al.   PLoS One

Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK

(2012) Ming Wang et al.   FEBS LETTERS

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity

(2012) N. M. Teplyuk et al.   NEURO-ONCOLOGY

MiR-328 Expression Is Decreased in High-Grade Gliomas and Is Associated with Worse Survival in Primary Glioblastoma

(2012) Zhifeng Wu et al.   PLoS One

Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression

(2011) D.S. Markovic et al.   BRAIN BEHAVIOR AND IMMUNITY

A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs

(2011) T.-M. Kim et al.   CANCER RESEARCH

MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients

(2011) Radek Lakomy et al.   CANCER SCIENCE

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma

(2011) Jennifer Permuth-Wey et al.   JOURNAL OF NEURO-ONCOLOGY

A specific miRNA signature in the peripheral blood of glioblastoma patients

(2011) Patrick Roth et al.   JOURNAL OF NEUROCHEMISTRY

A Ten-microRNA Expression Signature Predicts Survival in Glioblastoma

(2011) Sujaya Srinivasan et al.   PLoS One

miR-195, miR-455-3p and miR-10a∗ are implicated in acquired temozolomide resistance in glioblastoma multiforme cells

(2010) Kenta Ujifuku et al.   CANCER LETTERS

MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme

(2009) Yiming Li et al.   BRAIN RESEARCH

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

(2008) Joachim Silber et al.   BMC Medicine

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM)

(2008) W. J. Lukiw et al.   JOURNAL OF NEURO-ONCOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY