Article
Clinical Neurology
Christoph Bettag, Katharina Schregel, Philip Langer, Carolina Thomas, Daniel Behme, Christine Stadelmann, Veit Rohde, Dorothee Mielke
Summary: The study found that combined microscopic and endoscopic fluorescence-guided resection significantly increases the extent of resection in GBM patients, allowing surgeons to achieve a supratotal resection beyond the borders of contrast enhancement in noneloquently located GBM.
NEUROSURGICAL FOCUS
(2021)
Article
Chemistry, Physical
Elham Gholibegloo, Anita Ebrahimpour, Tohid Mortezazadeh, Farzaneh Sorouri, Alireza Foroumadi, Loghman Firoozpour, Mehdi Shafiee Ardestani, Mehdi Khoobi
Summary: In this study, gadolinium oxide nanoparticles (Gd2O3 NPs) were loaded with 5-aminolevulinic acid (5-ALA) and assisted by intracellular iron, resulting in their ability to serve as a T1 contrast agent with T2* contrast ability. The NPs exhibited concentration-dependent toxicity against glioblastoma C6 cells and showed higher relaxation rates (R1 and R2*) compared to the controls. These findings suggest that Gd2O3 NPs loaded with 5-ALA and assisted by intracellular iron could be a promising contrast agent for glioblastoma diagnosis in MRI.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Clinical Neurology
Christoph Bettag, Bawarjan Schatlo, Tammam Abboud, Daniel Behme, Christoph Bock, Christian von der Brelie, Veit Rohde, Dorothee Mielke
Summary: Endoscope-assisted resection of glioblastoma enhances gross total resection and overall survival.
ACTA NEUROCHIRURGICA
(2023)
Article
Biochemistry & Molecular Biology
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Hideaki Watanabe, Kosuke Kusakabe, Mashio Taniwaki, Hajime Yano, Yoshihiro Ohtsuka, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Seiji Shigekawa, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda
Summary: This study analyzed the relationship between CD44 expression and magnetic resonance imaging (MRI)-based invasiveness of recurrent glioblastoma multiforme (GBM). High-invasive GBM showed significantly higher CD44 expression and was associated with worse survival. In addition, the study investigated the relationship between 5-aminolevulinic acid (5-ALA) spectroscopy-based tumor invasiveness and CD44 expression.
Article
Oncology
Matthew L. Scarpelli, Debbie R. Healey, Shwetal Mehta, C. Chad Quarles
Summary: This study aimed to investigate the association between multiple biological factors and fluciclovine PET uptake in human glioblastoma, and found that fluciclovine PET uptake was significantly correlated with the level of the amino acid transporter ASCT2 in tumor cells, suggesting that fluciclovine PET may be useful for assessing amino acid metabolism in brain tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Johannes Herta, Anna Cho, Thomas Roetzer-Pejrimovsky, Romana Hoeftberger, Wolfgang Marik, Gernot Kronreif, Tanja Peilnsteiner, Karl Roessler, Stefan Wolfsberger
Summary: The potential of 5-aminolevulinic acid (5-ALA) and Raman spectroscopy (RS) in detecting tumor-infiltrated brain in glioblastoma patients was assessed and compared. The study found that RS has higher sensitivity and 5-ALA has higher specificity in detecting tumor-infiltrated brain. Combining the two methods can increase the accuracy of tumor detection by about 10%.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, Research & Experimental
Elisa Checa-Chavarria, Eva Rivero-Buceta, Miguel Angel Sanchez Martos, Gema Martinez Navarrete, Cristina Soto-Sanchez, Pablo Botella, Eduardo Fernandez
Summary: This novel therapeutic approach using CPT-ALA shows promising results in targeting GBM cells with improved cytotoxic effects and reduced side effects on healthy tissue. In preclinical studies, CPT-ALA demonstrated significant reduction in intracranial GBM volume without notable toxicity, indicating its potential for improving the success of surgical removal and extending life expectancy by reducing tumor recurrence.
MOLECULAR PHARMACEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Nabavizadeh, Stephen J. Bagley, Robert K. Doot, Jeffrey B. Ware, Anthony J. Young, Satyam Ghodasara, Chao Zhao, Hannah Anderson, Erin Schubert, Erica L. Carpenter, Jacob Till, Fraser Henderson Jr, Austin R. Pantel, H. Isaac Chen, John Y. K. Lee, Nduka M. Amankulor, Donald M. O'Rourke, Arati Desai, MacLean P. Nasrallah, Steven Brem
Summary: 18F-fluciclovine PET combined with multiparametric MRI can accurately differentiate between pseudoprogression and tumor progression, which is of great value in neurooncology, and this method is widely available.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Denise Drongitis, Lucia Verrillo, Pasqualino De Marinis, Pasquale Orabona, Agnese Caiola, Giacinto Turitto, Alessandra Alfieri, Sara Bruscella, Marisa Gentile, Vania Moriello, Ettore Sannino, Ines Di Muccio, Valerio Costa, Maria Giuseppina Miano, Alberto de Bellis
Summary: This study highlights the role of chromatin remodeling gene KDM5C in Glioblastoma multiforme (GBM) and suggests HIF1A-KDM5C axis as a potential therapeutic target for the hypoxic microenvironment in GBM. The study provides extensive analysis of clinical, expression, and functional data, integrated with publicly available omic datasets, to show the contribution of KDM5C in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yosuke Kitagawa, Shota Tanaka, Mako Kamiya, Yugo Kuriki, Kyoko Yamamoto, Takenori Shimizu, Takahide Nejo, Taijun Hana, Reiko Matsuura, Tsukasa Koike, Erika Yamazawa, Yoshihiro Kushihara, Satoshi Takahashi, Masashi Nomura, Hirokazu Takami, Shunsaku Takayanagi, Akitake Mukasa, Yasuteru Urano, Nobuhito Saito
Summary: The study developed a novel fluorescent probe PR-HMRG that can be repeatedly administered as a topical spray during surgery for effective detection of glioblastoma. Further investigations are needed to evaluate its clinical efficacy and safety.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcel Lindemann, Ana Oteiza, Montserrat Martin-Armas, Yngve Guttormsen, Angel Moldes-Anaya, Rodrigo Berzaghi, Trond Velde Bogsrud, Tore Bach-Gansmo, Rune Sundset, Mathias Kranz
Summary: The study investigated the potential use of [F-18]rhPSMA-7.3 for quantitative imaging of neo-vascularization in GBM using PET/MRI. The results showed that [F-18]rhPSMA-7.3 had a higher tumor uptake compared to other tracers, and the uptake was associated with vascularization in the tumor.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Yoshinori Harada, Yasutoshi Murayama, Tetsuro Takamatsu, Eigo Otsuji, Hideo Tanaka
Summary: 5-Aminolevulinic acid (5-ALA) is a natural amino acid that can accumulate in cancer cells and be used for tumor visualization. However, its diagnostic applicability is challenging due to interference from tissue autofluorescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Barbara Kiesel, Lisa I. Wadiura, Mario Mischkulnig, Jessica Makolli, Veronika Sperl, Martin Borkovec, Julia Freund, Alexandra Lang, Matthias Millesi, Anna S. Berghoff, Julia Furtner, Adelheid Woehrer, Georg Widhalm
Summary: In the next decades, the incidence of glioblastoma (GBM) patients is expected to increase significantly due to the growth of the elderly population. Despite this, elderly patients are often excluded from clinical studies, leading to a lack of data specifically focusing on this population. However, the use of 5-ALA in elderly patients undergoing surgical treatment for GBM has shown to improve tumor visualization and safety, suggesting its utility in optimizing neurosurgical management.
Article
Orthopedics
Wiebke K. Guder, Wolfgang Hartmann, Clarissa Buhles, Maike Burdack, Maike Busch, Nicole Dunker, Jendrik Hardes, Uta Dirksen, Sebastian Bauer, Arne Streitbuerger
Summary: This study analyzed the fluorescence rate and photodynamic therapy (PDT) effects of musculoskeletal tumors using chick chorio-allantoic membrane (CAM) model exposed to 5-aminolevulinic acid (5-ALA). The results showed that the fluorescence rate of tumors was correlated with tumor type, and PDT could cause partial or complete regression of tumors. This study provides evidence for further investigation of PDT effects on musculoskeletal tumors and the incorporation of 5-ALA FGS in clinical Orthopedic Oncology care.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Safieh Ebrahimi, Farshad Mirzavi, Seyed Isaac Hashemy, Maryam Khaleghi Ghadiri, Walter Stummer, Ali Gorji
Summary: This study evaluated the potential anti-cancer synergy of aprepitant, a neurokinin-1 receptor antagonist, and 5-aminolevulinic acid (5-ALA) on U-87 human GBM cells. The combination treatment of aprepitant and 5-ALA showed significant growth inhibitory, pro-apoptotic, and anti-migratory effects on GBM cells. These effects were more prominent than either drug used alone. The findings provide a basis for further research on the combination of aprepitant and 5-ALA as a novel therapeutic approach for GBM.
Article
Dentistry, Oral Surgery & Medicine
Gregor Petersilka, Raphael Koch, Anna Vomhof, Tim Joda, Inga Harks, Nicole Arweiler, Benjamin Ehmke
Summary: The study compared the clinical outcomes of subgingival application of GPAP and sole conventional mechanical debridement (SC) during supportive periodontal therapy (SPT), finding that GPAP was equivalent to SC in terms of stable PPD sites, but showed a trend of deterioration in furcation status.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Obstetrics & Gynecology
Sarah Kleemann, Raphael Koch, Ralf Schmitz, Helen A. Koster, Janina Braun, Johannes Steinhard, Kathrin Oelmeier, Walter Klockenbusch, Mareike Mollers
Summary: Fetal thymus size appeared to be smaller in pregnancies affected by trisomy 18 and trisomy 13 compared to healthy fetuses, while fetuses with trisomy 21 and Turner syndrome did not show noticeable differences in thymus size. There were no statistically noticeable differences in CRL-thymus-ratios between separate study groups.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Christina Haeger, Kerstin Hammer, Janina Braun, Kathrin Oelmeier, Helen Ann Koester, Mareike Mollers, Raphael Koch, Johannes Steinhard, Walter Klockenbusch, Ralf Schmitz
Summary: This study aimed to assess the influence of frame rate settings on longitudinal strain and mechanical synchrony values in Speckle Tracking Echocardiography (STE) of healthy fetuses. The results showed that higher frame rates significantly increased longitudinal strain values, but had no significant impact on mechanical synchrony values. Therefore, selecting higher frame rates can provide more accurate cardiac examination in fetal Speckle Tracking Echocardiography.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Oncology
Michael Schwake, Michael Muether, Ann-Katrin Bruns, Bastian Zinnhardt, Nils Warneke, Markus Holling, Stephanie Schipmann, Benjamin Brokinkel, Johannes Woelfer, Walter Stummer, Oliver Grauer
Summary: This study reports on the combination of 5-ALA fluorescence-guided resection and intracavitary thermotherapy with superparamagnetic iron oxide nanoparticles for the treatment of recurrent high-grade gliomas. The results show that this treatment option provides a promising approach to improve local tumor control, but further refinements are needed to decrease side effects, especially cerebral edema.
Article
Oncology
Raphael Koch, Hans Gelderblom, Lianne Haveman, Benedicte Brichard, Heribert Juergens, Sona Cyprova, Henk van den Berg, Wolf Hassenpflug, Anna Raciborska, Torben Ek, Daniel Baumhoer, Gerardine Egerer, Hans Theodor Eich, Marleen Renard, Peter Hauser, Stefan Burdach, Judith Bovee, Fiona Bonar, Peter Reichardt, Jarmila Kruseova, Jendrik Hardes, Thomas Kuhne, Torsten Kessler, Stephane Collaud, Marie Bernkopf, Trude Butterfass-Bahloul, Catharina Dhooge, Sebastian Bauer, Janos Kiss, Michael Paulussen, Angela Hong, Andreas Ranft, Beate Timmermann, Jelena Rascon, Volker Vieth, Jukka Kanerva, Andreas Faldum, Markus Metzler, Wolfgang Hartmann, Lars Hjorth, Vivek Bhadri, Uta Dirksen
Summary: The study evaluated the effect of high-dose chemotherapy followed by reinfusion of autologous hematopoietic stem cells on survival in high-risk Ewing sarcoma patients. The results showed no benefit of TreoMel-HDT for the entire cohort, but it may be beneficial for patients younger than 14 years. This observation is supported by other studies.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Gerold Thoelking, Filiz Tosun-Koc, Ulrich Jehn, Raphael Koch, Hermann Pavenstaedt, Barbara Suwelack, Stefan Reuter
Summary: A switch from immediate-release tacrolimus (IR-Tac) to extended-release tacrolimus (LCPT) can improve renal function in kidney transplant recipients, particularly in fast metabolizers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kay-Arne Walther, Jose Roberto Gonzales, Sabine Groeger, Benjamin Ehmke, Dogan Kaner, Katrin Lorenz, Peter Eickholz, Thomas Kocher, Ti-Sun Kim, Ulrich Schlagenhauf, Raphael Koch, Joerg Meyle
Summary: This study investigated the role of Interleukin-(IL)-1, IL-4, GATA-3, and Cyclooxygenase-(COX)-2 polymorphisms in periodontitis progression after non-surgical therapy with adjunctive systemic antibiotics in a Caucasian population. The study found a slight association between GATA-3 gene locus and clinical attachment levels (CAL).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Michael Muether, Wolfram Schwindt, Rolf Michael Mesters, Jens Minnerup, Paul Stracke, Markus Holling, Heinz Wiendl, Walter Stummer
Summary: Andexanet alfa can cause heparin resistance, leading to catastrophic events. Regulatory bodies have issued warning notices to avoid concurrent use of heparin with andexanet alfa.
NEUROCRITICAL CARE
(2022)
Article
Hematology
Andrew F. Berdel, Raphael Koch, Joachim Gerss, Marcus Hentrich, Rudolf Peceny, Tobias Bartscht, Bjoern Steffen, Marina Bischoff, Karsten Spiekermann, Linus Angenendt, Jan-Henrik Mikesch, Tobias Kewitz, Trude Butterfass-Bahloul, Hubert Serve, Georg Lenz, Wolfgang E. Berdel, Utz Krug, Christoph Schliemann
Summary: This study investigated the safety and efficacy of adding nintedanib to low-dose cytarabine treatment in elderly patients with AML who were not eligible for intensive chemotherapy. The results showed that nintedanib did not demonstrate superior therapeutic activity compared to placebo in this population.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Malte Traeger, Leonille Schweizer, Eilis Perez, Simone Schmid, Elisabeth G. Hain, Carsten Dittmayer, Julia Onken, Kohei Fukuoka, Koichi Ichimura, Ulrich Schueller, Lasse Duehrsen, Michael Muether, Werner Paulus, Christian Thomas, Marielena Gutt-Will, Philippe Schucht, Theoni Maragkou, Jens Schittenhelm, Franziska Eckert, Maximilian Niyazi, Daniel F. Fleischmann, Mario M. Dorostkar, Petra Feyer, Sven-Axel May, Dag Moskopp, Harun Badakhshi, Cornelia Radke, Jan Walter, Felix Ehret, David Capper, David Kaul
Summary: DNA methylation profiling improves diagnostic accuracy and risk stratification in adult intracranial ependymoma. Gross total resection (GTR) and postoperative radiotherapy may represent key factors in determining the outcome of EPN-PFB patients.
Article
Medicine, General & Internal
Arturo Silvero Isidre, Hendrik Friederichs, Michael Muether, Marco Gallus, Walter Stummer, Markus Holling
Summary: Adding an MR neurosurgical simulation module to an undergraduate neurosurgical hands-on course can significantly improve the satisfaction of medical students. The positive feedback from medical students encourages the adoption of disruptive technologies into medical school curricula.
MEDICINA-LITHUANIA
(2023)
Article
Critical Care Medicine
Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Christian Porschen, Oliver Hartmann, Deborah Bergmann, Peter Pickkers, Alexander Zarbock
Summary: Plasma penKid may be a useful biomarker for predicting shorter duration and higher success rate of liberation from renal replacement therapy (RRT) in critically ill patients.
Meeting Abstract
Transplantation
Gerold Thoelking, Filiz Tosun, Ulrich Jehn, Raphael Koch, Hermann Josef Pavenstaedt, Barbara Suwelack, Stefan Reuter
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
G. Thoelking, B. Filensky, U. Jehn, K. Schuette-Nuetgen, R. Koch, C. Kurschat, H. Pavenstaedt, B. Suwelack, D. Kuypers, S. Reuter
TRANSPLANT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Michael Schwake, Emanuele Maragno, Marco Gallus, Stephanie Schipmann, Dorothee Spille, Bilal Al Barim, Walter Stummer, Michael Muether
Summary: This study compared facet-sparing and facetectomy approaches for treating lumbar spine dumbbell tumors. The results showed that the facetectomy approach was superior to facet-sparing in terms of local tumor control, achieving a higher rate of complete resection.
MEDICINA-LITHUANIA
(2022)